Psychiatric Behavior and Heredity
Association study of the polymorphism of MAOA gene with panic disorder
Zou Zhili, Huang Yulan, Wang Jinyu, Qiu Jian, Min Wenjiao, He Ying, Zhou Bo
Published 2017-10-20
Cite as Chin J Behav Med & Brain Sci, 2017,26(10): 913-916. DOI: 10.3760/cma.j.issn.1674-6554.2017.10.010
Abstract
ObjectiveTo explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and panic disorder, and then to compare panic disorder(PD) severity patient with different MAOA VNTR genotypes.
MethodsThe structured clinical interview for the diagnostic and statistical manual of mental disorders fourth edition (DSM-IV) Axis I Disorders (SCID-1) was administered by a trained clinical psychiatrist, 135 patients with PD and 195 healthy controls were recruited.MAOA-VNTR polymorphism were measured by fluorescent tags amplification product length polymorphism technology, Chi-square test was used to compare the distribution difference between each genotype and the allele frequency distribution.
Results①Whether male or female, there was no statistically significant difference between case group and healthy control group in the genotype and allele frequencies of MAOA-VNTR polymorphism (χ2=1.574, 1.894, 3.588; all P<0.05). ② There was no statistically significant difference between genotypes and panic disorder severity in the male with panic disorder((14.46±3.53), (14.15±4.02); t=-0.247, P>0.05). ③However, there was significant difference between genotypes and panic disorder severity in the female with panic disorder((13.15±3.47), (16.57±4.34), (15.27±4.91); F=4.222, P<0.05). MAOA VNTR-L/L carriers experienced more serious panic (16.57±4.34) than the patient with MAOA VNTR-H/H (13.15±3.47)(P<0.01) by LSD multiple test.
ConclusionNo association between MAOA-VNTR polymorphism and panic disorder is found in Chinese Han population, but low activity homozygous genotype may be related to the severity of panic disorder in female patient with panic disorder.
Key words:
Panic disorder; Monoamine oxidase A gene; Polymorphism
Contributor Information
Zou Zhili
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Huang Yulan
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Wang Jinyu
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Qiu Jian
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Min Wenjiao
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
He Ying
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
Zhou Bo
Department of Psychosomatic, Sichuan Provincial People’s Hospital, Chengdu 610072, China
