Clinical Research
Micro-anatomic distribution of peri-arterial renal sympathetic nerves
Junfei Gu, Yumei Ma, Lixin Ren, Zhu Wang, Wenjing Chai, Jianxing Li, Qing Zhao, Hongxu Huo, Yong Zhang, Wei Cui
Published 2017-03-08
Cite as Chin J Exp Surg, 2017, 34(3): 503-505. DOI: 10.3760/cma.j.issn.1001-9030.2017.03.046
Abstract
ObjectiveTo investigate the distribution of sympathetic nerves around human renal arteries.
MethodsWe collected 25 renal arteries from the patients who had a retroperitoneal laparoscopic nephrectomy and bilateral renal arteries from 7 human autopsy subjects. Each artery was equally divided into segments, which were made into paraffin sections. We examined the distribution of nerves around renal arteries and manually counted nerves by using optical microscope.
ResultsA total of 3 065 nerves were identified from 258 sections. About 98% of all nerves existed within the renal arterial adventitia and the outside tissue. The mean number of nerves between the ventral, doirsal, superior, and inferior region of surgical specimens was 4.7±1.3, 1.4±0.7, 3.1±1.3, and 2.1±1.2, respectively. The mean number of nerves in the ventral region was greater compared with the doirsal region (P=0.000), the mean number of nerves in the superior region was also greater compared with the inferior region (P=0.005). The mean number of nerves in the middle segments was obviously greater compared with the distal segments (14.5±4.4 and 8.3±3.0, P=0.000). The mean number of nerves between the ventral, doirsal, superior, and inferior region of autopsy specimens was 5.4±1.4, 1.5±0.7, 3.1±0.8, and 2.8±1.0, respectively. The mean number of nerves in the ventral region was greater compared with the doirsal region(P=0.000), whereas the mean number of nerves was similar between the superior and inferior region (P=0.440). The mean number of nerves among the proximal, middle, and distal segments was 11.2±4.4, 17.6±4.4, and 8.5±2.2. It was obvious that the mean number of nerves in the middle segments was greater compared with the proximal and diatal segments (P=0.000). The distribution of sympathetic nerves around the left renal arteries was not considerably different compared with the right renal arteries (Psurgical=0.100, Pautopsy=0.916).
ConclusionThe mean number of nerves in the ventral region is greatest and least in the doirsal region. Along the renal artery, the distribution of nerves is relatively greater in the middle segments. Nerve anatomic distribution around the left renal arteries was not considerably different compared with the right renal arteries.
Key words:
Renal sympathetic denervation; Resistant hypertension; Renal artery; Sympathetic nerves; Anatomic distribution
Contributor Information
Junfei Gu
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Yumei Ma
Department of Pathology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Lixin Ren
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Zhu Wang
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Wenjing Chai
Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Jianxing Li
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Qing Zhao
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Hongxu Huo
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Yong Zhang
Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Wei Cui
Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
