Glial scar is one of the obstacles to the regeneration of axons after spinal cord injury, which has no effective treatment in clinical practice. After spinal cord injury, inflammation and ischemia stimulate the release of inflammatory cytokines, which induce astrogliosis and formation of glial scar via janus kinase (JAK)/signal transducer and activators of transcription 3 (STAT3) signaling pathway. Curcumin, as a natural phenolic compound, has good anti-inflammatory, anti-fibrotic effects. Studies have shown that curcumin can inhibit the formation of glial scar by inhibiting the JAK/STAT3 signaling pathway, which promotes the regeneration and repair of spinal cord injury. This article summarizes the role of curcumin in the repair of spinal cord injury, and its future research direction, in order to provide helps for the treatment of spinal cord injury in clinic.