Clinical Researches
Effect of cocktail therapy on local inflammatory factors of incision after total hip arthroplasty
Zhang Zhiwei, Xiong Zhizheng, Jin Wen, Luo Chao, Gu Zhen, Peng Yuewen, Li Wenhua, Xu Xiao, Cui Guanglin, Yang Wen, Wang Kaijia, Zhang Xu
Published 2022-04-08
Cite as Chin J Exp Surg, 2022, 39(4): 764-766. DOI: 10.3760/cma.j.cn421213-20210828-01250
Abstract
ObjectiveTo investigate the effect of cocktail therapy on local inflammatory factors in early incision after total hip arthroplasty (THA).
MethodsTotally, 61 elderly patients with femoral neck fracture diagnosed in Yueyang People’s Hospital from June 2019 to December 2020 undergoing unilateral and initial THA were randomly divided into cocktail therapy group (31 cases) and control group (30 cases). After the prosthesis was placed in the cocktail therapy group, 60 ml cocktail drug was injected locally into the anterior and posterior joint capsule, surrounding muscles, deep fascia and subcutaneous parts of the hip joint, while the control group was not injected locally. The levels of C-reactive protein (CRP), interleukin-6 (IL-6) and serum amyloid A (SAA) in incision drainage fluid samples were determined at 1, 4, 7 and 24 h after operation.T-test was used for comparison between the two groups; If not, Wilcoxon rank sum test was used for comparison. Chi square test was used to compare the differences between groups in categorical variables.
ResultsThe levels of CRP, SAA and IL-6 in incision drainage fluid samples at 1, 4, 7 and 24 h after THA were compared between cocktail therapy group and control group as follows: for CRP, (3.79±1.39) mg/L vs. (10.53±1.52) mg/L (t=18.089, P<0.05), (6.32±3.12) mg/L vs. (14.78±2.79) mg/L (t=11.156, P<0.05), (11.10±3.79) mg/L vs. (18.60±1.26) mg/L (t=10.433, P<0.05), (30.13±5.28) mg/L vs. (38.82±5.70) mg/L (t=6.183, P<0.05); for IL-6, (4.59±1.51) mg/L vs. (7.12±1.15) mg/L (t=7.326, P<0.05), (7.13±1.74) mg/L vs. (9.94±2.71) mg/L (t=4.793, P<0.05), (17.35±2.62) mg/L vs. (20.83±2.57) mg/L (t=5.228, P<0.05), (13.31±3.62) mg/L vs. (15.24±3.10) mg/L (t=2.229, P<0.05); for SAA, (4.94±0.98) mg/L vs. (5.89±0.89) mg/L (t=3.957, P<0.05), (6.15±1.21) mg/L vs. (7.84±2.60) mg/L (t=3.233, P<0.05), (6.56±1.78) mg/L vs. (9.28±2.91) mg/L (t=4.376, P<0.05), (25.15±3.22) mg/L vs. (27.20±4.29) mg/L (t=2.106, P<0.05). Compared with the control group, CRP, SAA and IL-6 levels in the cocktail therapy group were significantly reduced (P<0.05).
ConclusionCocktail therapy can reduce the levels of CRP, SAA and IL-6 in early incision drainage fluid after THA to a certain extent.
Key words:
Cocktail therapy; Total hip arthroplasty; Inflammatory factors
Contributor Information
Zhang Zhiwei
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Xiong Zhizheng
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Jin Wen
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Luo Chao
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Gu Zhen
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Peng Yuewen
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Li Wenhua
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Xu Xiao
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Cui Guanglin
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Yang Wen
Department of Traditional Chinese Medicine, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Wang Kaijia
Department of Laboratory, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
Zhang Xu
Department of Orthopedics, Yueyang People’s Hospital (Yueyang Hospital Affiliated to Hunan Normal University), Yueyang 414000, China
