Colorectal Surgery
Construction and validation of prognosis model of immune related genes in colorectal cancer
Yang Changjiang, Lin Yilin, Zhao Long, Ye Yingjiang, Wang Shan, Shen Zhanlong
Published 2023-03-08
Cite as Chin J Exp Surg, 2023, 40(3): 413-416. DOI: 10.3760/cma.j.cn421213-20210404-00281
Abstract
ObjectiveTo evaluate the prognosis of colorectal cancer patients by constructing the prognosis model of immune related genes.
MethodsGene expression data and clinical information were downloaded from Gene Expression Omnibus and The Cancer Genome Atlas. The differentially expressed immune related genes were screened. The prognostic risk model was established based on univariate and multivariate Cox regression analysis. Furthermore, the application value of the model for clinical prognosis evaluation was analyzed. The model was validated by external datasets.
ResultsA total of 85 differentially expressed immune-related genes were identified. Eight genes including C-X-C motif chemokine ligand 3 (CXCL3), adiponectin receptor protein 1 (ADIPOQ), guanine nucleotide-binding protein G (i) subunit alpha-1 (GNAI1), endothelial cell-specific molecule 1 (ESM1), protein jagged-2 (JAG2), leukemia inhibitory factor (LIF), vasoactive intestinal peptide (VIP), mineralocorticoid receptor (NR3C2) were screened to establish a risk model. The risk score based on the model was significantly correlated with the overall survival rate. The prognosis of the high-risk group was worse than that of the low-risk group (χ2=22.611, P<0.001). The risk score was an independent prognostic factor for colorectal cancer patients [hazard ratio (HR)=1.154, 95% confidence interval: 1.091-1.220, P<0.01]. The area under receiver operating characteristic (ROC) curve for this model is 0.763, which can be used to distinguish high risk and low risk colorectal cancer patients.
ConclusionThis study successfully constructed the prognosis model of colorectal cancer based on the immune related genes, which provides a new method for predicting the prognosis of colorectal cancer patients.
Key words:
Colorectal cancer; Immune-related genes; Prognosis
Contributor Information
Yang Changjiang
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
Lin Yilin
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
Zhao Long
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
Ye Yingjiang
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
Wang Shan
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
Shen Zhanlong
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Laboratory of General Surgery, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
