The phosphoinositide 3-kinase(PI3K)-Akt/protein kinase B (PKB)-mammalian target of rapamycin (mTOR) pathway is one of the significant signal transduction pathways in various tumor cells. By regulating different downstream molecules, it participates in and regulates various malignant biological behaviors of tumor cells including proliferation and apoptosis. With the in-depth research on the composition and molecular mechanism of the PAM pathway, inhibitors targeting different sites of the pathway have gradually entered the stage of clinical trials, and have gradually shown their potential as tumor therapeutic targets. This article aims to review and prospect a variety of PAM pathway inhibitors, as well as the combination of these inhibitors with other tumor treatment modalities.

Phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin; Signal pathway; Inhibitor; Tumor; Combination therapy