Original Article
Effect of the ioversol on early renal function in patients undergoing cerebral vascular intervention
Zhang Guilian, Li Tingting, Guo Yingying, Zhang Lei, Ma Zhulin, Wang Heying, Li Tao, Liu Jiao
Published 2017-07-20
Cite as , 2017,19(07): 1002-1006. DOI: 10.3760/cma.j.issn.1008-1372.2017.07.011
Abstract
ObjectiveTo investigate the effect of different doses of ioversol on renal function, and to explore early renal injury biomarkers on contrast induced kidney injury and safe ioversol dosage.
MethodsA total of 158 cases (98 males and 60 females) undergoing cerebral vascular intervention (CVI) in our department was selected with age ranging from 23 to 81 years old (average age 59.70±12.02). Based on ioversol dosage in surgery, patients were divided into three groups: low dose group (≤150 ml, n=49), middle dose group (151-200 ml, n=74), and high dose group (>200 ml, n=35). U-κ, U-λ, urinary transferrin (UTRF), urine microalbumin (UMA), urinary immunoglobulin IgG (UIgG), urine beta2-microglobulin (Uβ2-MG), Uα1-MG, urinary N-acetyl-beta-D-glucosaminidase (UNAG), plasma cystatin C (CysC) and Scr were detected by scattering turbidimetry, immune turbidimetry and fully automatic biochemical analysis pre-surgery 24 h and post-surgery 72 h. Contrast-induced acute kidney injury (CI-AKI) was defined as laboratory increase of Scr value≥44.2 μmol/L or ≥25% from baseline measurement at 48hours after surgery. The relationship in ioversol dosage and various factors was assessed by Single and multiple factors binary logistic regression analysis.
ResultsAccording to the criterion that Scr increase value were ≥44.2 μmol/L, of 158 cases, 3 cases occurred CI-AKI, the AKI incidence was 1.90%. Based on the criterion that Scr increase value was ≥25%, 33 cases occurred CI-AKI, the incidence was 20.89%. The concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC were significantly different in high dose group compared to low ioversol dose group (P<0.05), while the other biomarkers had no significant difference (P>0.05).
ConclusionsThe contrast media-ioversol could lead to CI-AKI; when the dosage of ioversol was more than 200 ml one-time, the concentration of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC increased significantly. U-κ, UTRF, Uα1-MG, UNAG and plasma CysC could predict the early renal injury in patients who undergoing CVI. The rise of U-κ, UTRF, Uα1-MG, UNAG and plasma CysC are related to the dosage of ioversol. Furthermore, possibility of kidney injury is significantly high when ioversol dosage is more than 200 ml one-time.
Key words:
Triiodobenzoic acids/AD; Contrast media/AD; Kidney/IN; Radiography, interventional; Kidney function tests
Contributor Information
Zhang Guilian
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
Li Tingting
Department of Neurology, the Central Hospital of Xianyang, Xianyang, 702000, China
Guo Yingying
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
Zhang Lei
Department of Neurology, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
Ma Zhulin
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
Wang Heying
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
Li Tao
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
Liu Jiao
Department of Neurology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China
