Original Article
The value of HP combined with serum CEA, CA72-4 and CA24-2 in early gastric cancer screening
Junping An, Bin Liu, Aili Shi, Qilong Chen
Published 2017-08-20
Cite as J Chin Physician, 2017, 19(8): 1165-1167,1171. DOI: 10.3760/cma.j.issn.1008-1372.2017.08.011
Abstract
ObjectiveTo investigate the value of Helicobacter pylori (HP), blood carcinoembryonic antigen (CEA), carbohydrate antigens 72-4 (CA72-4) and CA24-2 in the screening of gastric cancer.
MethodsThe contents of HP, blood CEA, CA72-4 and CA24-2 in 50 healthy controls, 45 patients with benign gastric lesions and 70 patients with gastric cancer were detected. According to the number of positive cases, the positive rate of single detection and the positive rate of combined detection were calculated. Sensitivity, specificity, and accuracy of serum tumor markers were calculated according to HP single and combined detection.
ResultsThe positive rate of each individual detection and 4 joint detection in gastric cancer group was significantly different from that in the benign lesion group and the normal control group (P<0.01). The positive rate of 4 joint detection in gastric cancer group was 89.25%, and the difference was statistically significant (P<0.01). There was no significant difference in the positive rate of the single test and the 4 joint detection in benign stomach group and normal control group (P>0.05). The sensitivity, specificity and accuracy of HP, blood CEA, CA72-4, CA24-2 joint detection were significantly higher than single detection (P<0.05).
ConclusionsJoint detection was significantly better than single detection, and can significantly improve the detection rate of gastric cancer.
Key words:
Helicobacter pylori; Carcinoembryonic antigen; Antigens, tumor-associated, carbohydrate; Stomach neoplasms/DI
Contributor Information
Junping An
Department of Gastroenterology, Cancer Hospital of Xuzhou, Xuzhou 221002, China
Bin Liu
Aili Shi
Qilong Chen
