Review
Research progress of stem cells and gene therapy for erectile dysfunction
Lei Wang, Mingzong Yue, Guangzhou Cheng, Yuxi Shan
Published 2018-10-20
Cite as J Chin Physician, 2018, 20(10): 1597-1600,封三. DOI: 10.3760/cma.j.issn.1008-1372.2018.10.050
Abstract
Erectile dysfunction (ED) is a highly prevalent health problem with considerable impact on the quality of men and their partners. There are many drawbacks in the existing ED treatment. Stem cells have the function of self-renewal and differentiation into various cell types. Gene therapy mainly focuses on the regulation of various transmitters and enzymes in nitricoxide synthase/cyclic guanosine monophosphate (NOS/c GMP) pathway, growth factors, peptides and channel proteins, which make them have broad application prospects in the field of ED treatment. In recent years, stem cell and gene therapy of ED have achieved initial results. This article aims to review the latest research progress in this field.
Key words:
Erectile dysfunction/TH; Stem cell transplantation; Gene therapy; Review
Contributor Information
Lei Wang
Department of Urology Surgery, Jining Medical College Affiliated Tengzhou Central People′s Hospital, Jining 277500, China
Department of Urology Surgery, The Second Hospital Affiliated to Suzhou University, Suzhou 215000, China
Mingzong Yue
Department of Urology Surgery, The Second Hospital Affiliated to Suzhou University, Suzhou 215000, China
Guangzhou Cheng
Department of Urology Surgery, Jining Medical College Affiliated Tengzhou Central People′s Hospital, Jining 277500, China
Yuxi Shan
Department of Urology Surgery, The Second Hospital Affiliated to Suzhou University, Suzhou 215000, China