Original Article
Diagnostic value of TNF-α in patients with pulmonary infection after liver transplantation
Bai Lei, Li Tao, He Yibiao, Wang Zhipeng, Zhao Jinming, Ji Xuewen
Published 2021-06-20
Cite as J Chin Physician, 2021, 23(6): 874-877. DOI: 10.3760/cma.j.cn431274-20200610-00779
Abstract
ObjectiveTo explore diagnostic value of tumor necrosis factor-α (TNF-α) in patients with pulmonary infection after liver transplantation.
MethodsThe clinical data of 80 patients with pulmonary infection after liver transplantation in the the First Affiliated Hospital of Xinjiang Medical University from January 2016 to May 2019 were retrospectively analyzed. According to different pathogens, they were divided into bacteria infection group (n=35) and non-bacteria infection group (n=45). The general data, levels of serum TNF-α, C-reactive protein (CRP) and procalcitonin (PCT) were compared between the two groups. Logistic regression was performed to explore risk factors for pulmonary infection after liver transplantation. Receiver operating characteristic (ROC) curves were performed to analyze diagnostic value of TNF-α, CRP and PCT.
ResultsThe levels of serum TNF-α, CRP and PCT in bacteria infection group were significantly higher than those in non-bacteria infection group (P<0.05). Multivariate analysis showed that high TNF-α, CRP, and PCT levels were independent risk factors for bacterial pneumonia after liver transplantation. ROC analysis showed that sensitivity, specificity and areas under ROC curves (AUC) of TNF-α, CRP and PCT for diagnosis of bacterial pulmonary infection after liver transplantation were (80.12%, 72.12%, 80.18%), (83.45%, 73.46%, 83.38%) and (0.802, 0.751, 0.803), respectively. The AUC, sensitivity, and specificity between TNF-α and PCT for diagnosis of bacterial pulmonary infection after liver transplantation were similar (P>0.05). The AUC, sensitivity and specificity of TNF-α for diagnosis of bacterial pulmonary infection after liver transplantation were better than those of CRP (P<0.05).
ConclusionsThe diagnostic value of TNF-α for pulmonary infection after liver transplantation is similar to that of PCT, and is superior to CRP. It can be applied as a reliable index for identifying bacterial pneumonia and non-bacterial pneumonia.
Key words:
Tumor necrosis factor-alpha; Liver transplantation; Pneumonia, bacterial; Postoperative complications
Contributor Information
Bai Lei
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Li Tao
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
He Yibiao
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Wang Zhipeng
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Zhao Jinming
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Ji Xuewen
Department of Laparoscopic Surgery of Liver, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
