Original Article
Effects of morning blood pressure on vascular endothelial function and chronic inflammatory response in the elderly
Tao Xiufang, Zhao Mingchen, Chen Xuemei, Zhang Hua, Liu Zhendong
Published 2022-02-20
Cite as J Chin Physician, 2022, 24(2): 226-230. DOI: 10.3760/cma.j.cn431274-20201229-01754
Abstract
ObjectivesTo investigate the effects of morning blood pressure on vascular endothelial function and chronic inflammatory response in the elderly.
Methods349 elderly people aged ≥60 who underwent 24-hour ambulatory blood pressure monitoring in Gaomi Municipal Hospital from April 2018 to October 2019 were selected to detect brachial artery flow mediated vasodilation (FMD) and chronic inflammatory factors [high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and interleukin (IL)-17] levels. According to the results of 24-hour ambulatory blood pressure monitoring, the subjects were divided into normal blood pressure group (n=108), simple morning hypertension group (n=114) and hypertension group (n=127). The clinical data, 24-hour ambulatory blood pressure parameters, vascular endothelial function and inflammatory factors of the three groups were compared. The correlation between 24-hour ambulatory blood pressure parameters and FMD and inflammatory factors was analyzed by partial correlation.
ResultsCompared with the normal blood pressure group, the simple morning hypertension group and the hypertension group had lower FMD (all P<0.05), higher serum hsCRP and TNF-α , IL-17 levels (all P<0.05). Compared with the simple morning hypertension group, the hypertension group had lower FMD (P<0.05), higher serum hsCRP, TNF-α and IL-17 levels (all P<0.05). After controlling for age, sex, smoking history, drinking history, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose and 24 h average blood pressure, the morning systolic blood pressure was negatively correlated with FMD (P<0.05), and positively correlated with serum hsCRP and TNF-α and IL-17 levels (all P<0.05); the morning diastolic blood pressure was negatively correlated with FMD (P<0.05) and positively correlated with serum hsCRP and TNF-α levels (all P<0.05).
ConclusionsMorning blood pressure level is closely related to vascular endothelial function and chronic inflammation level, and is independent of 24-hour average blood pressure. The increase of morning blood pressure may be an important risk factor for endothelial dysfunction and chronic inflammation in the elderly.
Key words:
Aged; Morning blood pressure; Endothelial function; Inflammatory factor
Contributor Information
Tao Xiufang
Department of Endocrinology, Gaomi Municipal Hospital, Gaomi 261500, China
Zhao Mingchen
Department of Endocrinology, Gaomi Municipal Hospital, Gaomi 261500, China
Chen Xuemei
Department of Endocrinology, Gaomi Municipal Hospital, Gaomi 261500, China
Zhang Hua
School of Basic Medicine, Shandong First Medical University, Jinan 250062, China
Liu Zhendong
School of Basic Medicine, Shandong First Medical University, Jinan 250062, China
