Objectives To reduce the scrotum paget's disease of the misdiagnosis rate,improve the early diagnostic rate and survival rate.Methods A retrospective study of tumor hospital affiliated to sun yat-sen university (1999-2013),the clinical data of 36 cases of paget's disease of the scrotum,and follow-up and analysis.Results Ray stage A1 21 cases;A2 8 cases;B 6 cases; D 1 case;The scrotum Paget's disease combined sweat gland carcinoma 6 cases;The preferred treatment for patients with early metaphase is scrotal lesion wide resection;D period were treated by radiotherapy.7 cases of postoperative recurrence,1 of whom underwent palliative radiotherapy and taxol + cisplatin chemotherapy ;2 cases of radiation ;4 cases of scrotal Paget's disease recurrence resection of oven.36 patients were followed for an average time of 40 months,3 cases died of tumor metastasis,and survival time of 79 month respectively,78 month,23 months;3 cases died of other tumors,survival time 16 months respectively,20months,17 months.Conclusions Scrotal Paget's disease early biopsy is the key,the operation complete resection of lesions is the preferred treatment,early treatment prognosis is good.