Original Article
Effect of Bailing capsule on cellular immunity and renal function in patients with chronic renal failure CKD3-4
Zheng Xin, Chen Yi, Deng Yueyi
Published 2019-11-15
Cite as Int J Urol Nephrol, 2019, 39(6): 1081-1085. DOI: 10.3760/cma.j.issn.1673-4416.2019.06.033
Abstract
ObjectiveTo investigate the effect of Bailing capsule in the treatment of chronic renal failure (CRF).
MethodsA total of 120 patients with chronic renal failure CKD 3-4 who were admitted to Longhua hospital affiliated to Shanghai university of Chinese Medicine from January 2018 to May 2018 were randomly divided into control group and experimental group(n=60). The control group was given dietary control to regulate blood pressure, blood lipids, blood sugar. to correct anemia, improve acid-base imbalance and electrolyte imbalance, and the experimental group was given Bailing capsule on the basis of the control group. Continuous treatment for 3 months, comparing the total effective rate and renal function levels of the two groups, including serum creatinine (Scr), urea nitrogen (BUN), creatinine clearance (Ccr), T lymphocyte subsets and cytokine levels, including CD3+, CD4+, CD4+/CD8+, natural killer(NK) cells.
ResultsThe total effective rate of the experimental group after treatment was higher than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in T lymphocyte subsets and cytokine levels and renal function between the two groups before treatment (P>0.05). The renal function levels (Scr, BUN) of the two groups were better than those before treatment, and the experimental group was better than the control group, the difference was statistically significant (P<0.05). The level of Ccr after treatment was higher than that before treatment, and the experimental group was higher than the control group, the difference was statistically significant (P<0.05). The CD3+, CD4+, CD4+/CD8+, and natural killer (NK) cells were increased in the two groups after treatment. The difference between the two groups was statistically significant (P<0.05), and the experimental group had high T lymphocyte subsets. In the control group, the difference was statistically significant (P<0.05).
ConclusionsBailing capsule has a good clinical effect in the treatment of CRF, which can improve renal function and enhance immune function. It has certain clinical application value.
Key words:
Kidney Failure, Chronic; CHINESE PATENT DRUGS
Contributor Information
Zheng Xin
Department of Nephrology, Longhua Hospital Affiliated to Shanghai University of Chinese Medicine, Shanghai 200320, China
Chen Yi
Deng Yueyi
