To investigate the effects of regular hemodialysis and continuous renal replacement on renal function and microinflammation in diabetic patients with severe renal failure.

A retrospective analysis of 106 cases of diabetes with severe renal failure between January 2018 and January 2019 in our hospital was performed. According to the different modes of hemodialysis, all patients were divided into two groups, control group underwent regular hemodialysis treatment, and research group underwent continuous renal replacement therapy, 53 cases in each group.The changes of blood glucose, renal function, microinflammatory state and total effective rate before and after treatment were compared between the two groups.

The two groups before treatment glycated Hemoglobin A1c(HbA1c), fasting blood glucose(FBG), 2 hours postprandial blood glucose(2hPG), blood urea nitrogen(BUN), serum creatinine(Scr), blood homocysteine(Homo cysteine), Hcy and Hypersensitive c-reactive protein (hs-crp) showed no change before treatment between two groups(P>0.05). After treatment, the levels of HbA1c, FBG, 2 h PG, BUN, Scr, Hcy, hS-CRP were lower than those before treatment(P<0.05). The levels of HbA1c, FBG, 2hPG, BUN, Scr, Hcy and HS-CRP in the study group were lower than those in the control group, and the total effective rate was higher(P<0.05). Both groups of patients were followed up for 1 year.There were 6 patients in the study group(11.32%) who were out of dialysis and 1 patient in the control group(1.89%). The rate of disengagement from dialysis in the study group was significantly higher than that in the control group(χ²=11.205, P= 0.034).

Continuous renal replacement therapy is more effective than ordinary hemodialysis in patients with diabetic severe renal failure, which can improve the blood glucose level and the state of micro-inflammation, and promote the rapid recovery of renal function.

Key words Renal Insufficiency; Diabetes Mellitus; Renal Dialysis