Objective To explore the efficacy of two medical abortion approachs for terminating 8-14 weeks' gestation. Methods 135 pregnant women at 8 to 14 weeks was requested pregnancy termina tion were randomly divided into 2 groups: compound mifepristone group and mifepristone group. In the former group, 67 women received oral compound mifepristone (mifepristone 60 mg and anordrin 10 mg) one tablet twice on the first day, and then oral misoprostol of 0.6 mg 48 hours later, with vaginal misoprostol of 0.4mg every 4 hours (total dosage of misoprostol < 1.8 mg/day). In mifepristone group, 68 received oral mifepristone of 150mg once, and then the same use of misoprostol as the former group. Adverse reactions, vaginal bleeding, cramping, time from vaginal medication use to fetal delivery, bleeding volume during fetal dilivery, dosage of mifepristone, and application of D&C were noted. The women were followed up on days 15 and 45 to record duration and volume of vaginal bleeding and time to menstrual recovery. Results The success rate of abortion and rate of completed abortion were higher in compound mifepristone group than in mifepristone group. There were no significant differences in dosage of misoprostol, the time of discharging embro and placenta were ( 250.9 ± 174.15 ) minutes and ( 253.7 ± 148.70 ) minutes respectively.There were no significant differences (P>0.05). Conclutiona Compound mifepristone combined with misoprostol can terminate 8-12 weeks's gestation safely and effectively. It is simple and has a better efficacy with a ideal success rate of abortion and less dosage of mifepristone