Treatises
Expressions of p53 and Ki67 in colon cancer and the clinical significance
Mingjian Liu, Wenjuan Li
Published 2019-08-15
Cite as IMHGN, 2019, 25(16): 2695-2698. DOI: 10.3760/cma.j.issn.1007-1245.2019.16.024
Abstract
ObjectiveTo analyze the expression of p53 and Ki67 in colon cancer and the clinical significance, and to provide some references for the evaluation of the disease and prognosis.
MethodsThe expressions of p53 and Ki67 in pericancer mucosa and colon cancer were detected by immunohistochemistry. The relationship between the positive expressions of p53 and Ki67 and clinicopathological features was analyzed. The survival rates of the patients positive and negative in p53 and Ki67 expressions were compared.
ResultsThe positive rates of p53 and Ki67 in colon cancer were 71.64%(48/67) and 82.09%(55/67), which were significantly higher than those of the pericancer mucosa, with statistical differences (P<0.05). The positive rates of p53 in stage III and stage IV, medium and poorly differentiated, lymphaticmetastasis, invasion to the serosa were significantly higher than those in Stage I and II, high differentiated, non-lymphaticmetastasis, and non invasion to the serosa, with statistical differences (P<0.05). The patients were followed up until July, 2017; the 3 year survival rate of the p53 positive patients was 64.58%, which was significantly lower than that of the p53 negative patients, with a statistical difference (P<0.05).
ConclusionThere are high expressions of p53 and Ki67 in colon cancer. Ki67 is involved in cell proliferation. P53 can be used as an important indicator to evaluate the conditions and prognosis of colon cancer patients.
Key words:
Colon cancer; p53; Ki67; Expression; Clinical significance
Contributor Information
Mingjian Liu
Department of Digestive Medicine, Shanxian Central Hospital, Heze 274300, China
Wenjuan Li
Department of Critical Care Medicine, Jinxiang County People's Hospital, Jining 272200, China
