Treatises
Diagnostic value and postoperative observation of serum t-PSA, f-PSA, and CgA for patients with prostate cancer
Xu Zhiming, Deng Weiwu, Shi Zhenghu, Liao Siqin, Zou Wenbi
Published 2020-07-15
Cite as IMHGN, 2020, 26(14): 2101-2103. DOI: 10.3760/cma.j.issn.1007-1245.2020.14.030
Abstract
ObjectiveTo evaluate the diagnostic value of serum tumor t-PSA, f-PSA, and chromogranin A for patients with prostate cancer, and to obtain an optimal pattern of combined tumor markers.
MethodsThe serum levels of t-PSA, f-PSA, and chromogranin A in 50 patients with prostate cancer, 52 patients with benign prostate diseases, and 55 normal controls were measured; and data were analyzed by the receiver operating characteristic (ROC) curve.
ResultsThe serum levels of t-PSA, f-PSA, and chromogranin A in the prostate cancer group were higher than those in the prostate benign tumors group and those in the healthy control group (all P<0.05).The accuracy, sensitivity, specificity of the combination of the 3 indicators for prostate cancer and benign prostate diseases were 92.9%, 94.3%, and 92.1%. The serum levels of f-PSA, t-PSA, and CgA decreased rapidly after prostate cancer resection.
ConclusionsThe combination of t-PSA, f-PSA ,and chromogranin A is the optimal combination pattern of tumor markers, which is helpful for the diagnosis of prostate cancer and postoperative observation.
Key words:
Prostate cancer; PSA; CgA
Contributor Information
Xu Zhiming
Sanshui District People’s Hospital, Foshan 528100, China
Deng Weiwu
Sanshui District People’s Hospital, Foshan 528100, China
Shi Zhenghu
Department of Clinical Lab, Second Hospital, Shanxi University of Chinese Medicine, Xianyang 712000, China
Liao Siqin
Sanshui District People’s Hospital, Foshan 528100, China
Zou Wenbi
Sanshui District People’s Hospital, Foshan 528100, China
