Special Subject: Treatment for Stroke
Therapeutic effect and tolerance of tizanidine hydrochloride for spasticity of limbs after stroke
Wan Shaojie, Wang Yunhua, Chen Hongguo
Published 2020-08-15
Cite as IMHGN, 2020, 26(16): 2388-2391. DOI: 10.3760/cma.j.issn.1007-1245.2020.16.018
Abstract
ObjectiveTo investigate the effect and tolerance of tizanidine hydrochloride in the treatment of limb spasm after stroke.
MethodsFrom January, 2018 to January, 2019, 92 patients with upper extremity spasm after stroke were selected and divided into an observation group (n=47) and a control group (n=45) according to the treatment plans. The control group was routinely treated; in addition, the observation group was treated with tizanidine hydrochloride. The Modified Ashworth Spasticity Rating Scale (MAS), clinical spasticity index (CSI), and Simplified Fugl Meyer Exercise Scale (FMA) were observed before and after the treatment.
ResultsThe MAS rating was significantly better in the observation group than in the control group (P<0.05). After the treatment, the CSI score was lower and the FMA score was higher in the observation group than that of the control group [(5.50±1.01) vs. (7.80±1.12) and (30.20±6.11) vs. (25.60±5.50); bothP<0.05]. The incidence of adverse reactions in the observation group was 17.02%; among which 4 patients could not tolerate the adverse reactions.
ConclusionTizanidine hydrochloride has a good effect in the treatment of limb spasm after stroke, which is worth being clinically used.
Key words:
Tizanidine hydrochloride; Stroke; Limb spasm; Clinical effect
Contributor Information
Wan Shaojie
Department of Pharmacy, Yantai Yida Hospital, Yantai 264000, China
Wang Yunhua
Department of Neurological Surgery, Yantai Yida Hospital, Yantai 264000, China
Chen Hongguo
Department of Rehabilitation Medicine, Yantai Yida Hospital, Yantai 264000, China
