Scientific Research
Clinical effect of Qingying decoction combined with gamma globulin on Kawasaki disease
Zhang Zhou, Lai Laiqing, Luo Qiuyan, Yang Lixia, Guo Huixian, Liao Jiayi
Published 2021-07-15
Cite as IMHGN, 2021, 27(14): 2121-2124. DOI: 10.3760/cma.j.issn.1007-1245.2021.14.017
Abstract
ObjectiveTo evaluate the clinical effect of Qingying decoction combined with gamma globulin in the treatment of Kawasaki disease.
MethodsTwenty-eight children with Kawasaki disease admitted to our hospital from January 2019 to January 2020 were selected and were divided into a Qingying decoction group (6 cases) and a conventional western medicine group (22 cases) according to whether the children were treated with Qingying decoction or not. In the Qingying decoction group, there were 5 males and 1 female, with an age of (2.23±1.80) years old; in the conventional western medicine group, there were 15 males and 7 females, with an age of (1.65±1.09) years old. The conventional western medicine group was treated with gamma globulin and aspirin, and the Qingying decoction group was treated with oral Qingying decoction on the basis of the conventional western medicine group. The time of symptom disappearance, immune function levels, and laboratory related indicators of the two groups were observed.
ResultsThe disappearance time of fever, hand and foot swelling, conjunctival congestion, and rashes in the Qingying decoction group were (1.88±0.19) d, (2.27±0.12) d, (2.75±1.84) d, and (2.92±1.69) d, which were shorter than those in the conventional western medicine group [(2.64±0.50) d, (3.90±2.14) d, (5.29±1.94) d, and (5.02±2.32) d] (all P<0.05). The level of immunoglobulin A (IgA) in the Qingying decoction group was higher than that in the conventional western medicine group [1.12 (0.67, 2.35) g/L vs. 0.50 (0.35, 1.20) g/L] (P<0.05); there were no statistically significant differences in IgG and IgM levels between the two groups (bothP>0.05). There were no statistically significant differences in the levels of serum amyloid A (SAA), C-reactive protein (CRP), procalcitonin (PCT), and erythrocyte sedimentation rate (ESR) between the two groups (allP>0.05).
ConclusionQingying decoction combined with gamma globulin can improve the immune function of children with Kawasaki disease and shorten the disappearance time of clinical symptoms.
Key words:
Kawasaki disease; Qingying decoction; Gamma globulin; Immunoglobulin
Contributor Information
Zhang Zhou
Pediatric Internal Medicine, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Lai Laiqing
Pediatric Internal Medicine, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Luo Qiuyan
Preventive Treatment Department, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Yang Lixia
Preventive Treatment Department, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Guo Huixian
Pediatric Internal Medicine, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Liao Jiayi
Pediatric Internal Medicine, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
