Clinical Research
Correlation between eosinophils and first-use syndrome of dialyzer in hemodialysis patients during induction period
Wang Juan, Song Li, Quan Zilin, Sun Chunyan, Cui Dongmei, Zhao Liyan, Zhong Mi, Zhou Lifang, Chen Yinggui, Fu Xia
Published 2021-08-01
Cite as IMHGN, 2021, 27(15): 2367-2370. DOI: 10.3760/cma.j.issn.1007-1245.2021.15.039
Abstract
ObjectiveTo explore the correlation between eosinophils and the first-use syndrome (FUS) of dialyzer in hemodialysis patients.
MethodsThe clinical data of the first 3 dialysis sessions during induction period at Blood Purification Center, Guangdong Provincial People's Hospital from March 2017 to March 2019 were retrospectively collected. The patients were divided into a dialyzer allergy and a no dialyzer allergy group according to whether the FUS of dialyzer occurred during the first three sessions during their induction period. The eosinophil counts, white blood cell counts, and incidences of FUS were compared between these two groups.
ResultsOne hundred and twenty-eight patients were collected, including 59 males (46.1%); and they were (54.8±13.9) years old. The white blood cell count and the eosinophil count in the dialyzer allergy group were significantly higher than those in the no dialyzer allergy group [(6.46±1.82)×109/L vs. (5.70±1.58)×109/L, t=-2.247, P=0.026; 0.29 (0.18-0.80)×109/L vs. 0.26 (0.13～0.31)×109/L, W=1 550.5, P=0.045]. There were 29 patients (22.66%) with the eosinophil count ≥0.55×109/L and 99 patients (77.34%) with the eosinophil count ＜0.55 to 109/L. The incidence of FUS was 44.83% (13/29) in the dialyzer allergy group, and was 19.19% (19/99) in the no dialyzer allergy group (χ2=7.862, P=0.005).
ConclusionsEosinophil count is significantly increased in patients with FUS. Eosinophil count has a good specificity but a poor sensitivity in the diagnosis of FUS. For patients with increased eosinophil count before their first dialysis, it is recommended to select a dialyzer with good biocompatibility and to fully pre-fill the dialyzer to reduce the incidence of FUS.
Key words:
Eosinophils; Dialyzer; First-use syndrome
Contributor Information
Wang Juan
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Song Li
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Quan Zilin
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Sun Chunyan
School of Nursing, Southern Medical University, Guangzhou 510515, China
Cui Dongmei
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Zhao Liyan
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Zhong Mi
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
Zhou Lifang
School of Nursing, Southern Medical University, Guangzhou 510515, China
Chen Yinggui
School of Nursing, Southern Medical University, Guangzhou 510515, China
Fu Xia
Blood Purification Center, Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China
School of Nursing, Southern Medical University, Guangzhou 510515, China
Medical College, Shantou University, Shantou 515063, China
