Atrial fibrillation (AF) is one of the most common rapid arrhythmia, which can cause various complications, including thromboembrays, heart failure, cognitive dysfunction, etc, severely threatening human health. Studies have indicated that the autonomic neural remodeling, electrical remodeling, and atrial structure remodeling are involved in the occurrence of AF. In particular, the intrinsic autonomic neural remodeling plays an important role in the development of AF, but its intrinsic mechanism is still unclear. At present, the prevention and treatment effects of statins on arrhythmia have become hot spots of research. Statins can improve atrial structural remodeling after heart failure and over distribution of sympathetic nerves after myocardial infarction, but also have prevention and treatment effects on atrial arrhythmias such as atrial fibrillation. However, the mechanism of statins has not been fully clarified. This article mainly reviewed the relationship between atrial autonomic neural remodeling and AF, as well as the effects of statins on atrial autonomic neural remodeling and AF, to provide references for the clinical treatment of AF.

Atrial fibrillation; Atrium; Autonomic neural remodeling; Statins