To explore the changes in serum levels of brain natriuretic peptide (BNP) and hypersensitive C-reactive protein (hs-CRP) and their predictive values for long-term prognosis in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).

A total of 160 AMI patients undergoing PCI in Department of Cardiovascular Medicine, The Third Affiliated Hospital of Inner Mongolia Medical University from January 2019 to October 2020 were enrolled, including 117 males and 43 females, aged (57.54±11.90) years. Another 80 healthy controls during the same period were enrolled as a normal group, including 59 males and 21 females, aged (56.96±10.84) years. The AMI patients were followed up for 1 year. According to the presence or absence of major adverse cardiac events (MACE), they were divided into a non-MACE group and a MACE group. The changes of serum BNP and hs-CRP before and after surgery were compared between the two groups, and their predictive values for prognosis in patients with AMI were analyzed. t test was used for the measurement data, χ² test was used for the count data, and Z test was used for the area under curve (AUC).

The AMI patients were followed up for 1 year. There were 5 cases (3.13%) lost to follow-up. The incidence of MACE within 1 year in the AMI patients was 27.74% (43/155). According to the presence or absence of MACE, there were 43 cases in the poor prognosis group and 112 cases in the good prognosis group. Before and after surgery, there were statistically significant differences in the serum hs-CRP and BNP levels in the AMI patients (both P<0.05), and the serum hs-CRP and BNP levels in the AMI group were higher than those in the normal group (all P<0.05). Before surgery, the serum hs-CRP and BNP levels in the poor prognosis group were higher than those in the good prognosis group (both P<0.05); the difference of serum hs-CRP before and after surgery in the poor prognosis group was larger than that in the good prognosis group, and the difference of serum BNP before and after surgery was smaller than that in the good prognosis group (both P<0.05). According to the AUC, the optimal diagnostic cut-off points for the differences of serum hs-CRP and BNP before and after surgery were selected. The receiver operating characteristic curve (ROC) analysis showed that the AUC of the combination of differences of serum hs-CRP and BNP before and after surgery to predict the prognosis in AMI patients was 0.930, which was higher than that of the combination of serum hs-CRP and BNP before surgery (0.777) (P<0.05).

The combination of differences of serum BNP and hs-CRP in AMI patients before and after PCI has high efficacy in predicting the risk of MACE after PCI, which is worthy of clinical application.

Acute myocardial infarction; Brain natriuretic peptide B; Hypersensitive C-reactive protein; Prognosis; Percutaneous coronary intervention