Special Column of Urology and Reproduction
Study on the relationship between EMT and ureteral stricture after holmium laser lithotripsy for ureteral calculi
Zheng Pengyi, Zhang Yang, Wang Xiaohui, Li Huibing, Li Wensheng, Wang Kaixuan, Huang Hua, Lyu Shuangwu, Han Qingjiang, Li Zhijun
Published 2022-10-15
Cite as IMHGN, 2022, 28(20): 2906-2909. DOI: 10.3760/cma.j.issn.1007-1245.2022.20.020
Abstract
ObjectiveTo explore the relationship between epithelial-mesenchymal transition (EMT) and ureteral stricture after holmium laser lithotripsy for ureteral calculi.
MethodsA total of 34 patients with ureteral stricture after holmium laser lithotripsy for ureteral calculi in The First Affiliated Hospital of Henan University of Science and Technology between June 2019 and June 2021 were selected as the stricture group, including 19 males and 15 females, with an age of (44.54±10.35) years old. Another 34 patients without ureteral stricture after ureteral holmium laser lithotripsy during the same period were regarded as the non-stricture group according to the ratio of 1:1, including 20 males and 14 females, with an age of (45.56±9.57) years old. χ2 test or independent sample t test was used to compare the general data and serum levels of high mobility group protein B1 (HMGB1), interleukin-1β (IL-1β), and transforming growth factor-β1 (TGF-β1) between the two groups, and the receiver operating characteristic curve (ROC) was used to analyze the predictive efficacies of serum HMGB1, IL-1β, and TGF-β1 levels in ureteral stricture after holmium laser lithotripsy.
ResultsBefore surgery, there were no statistically significant differences in the serum HMGB1, IL-1β, and TGF-β1 levels between the two groups (all P>0.05); on the postoperative 7th day, the serum levels of HMGB1, IL-1β, and TGF-β1 in the stenosis group were (15.98±1.11) μg/L, (24.23±1.54) μg/L, and (381.58±38.52) ng/L, which were higher than those in the non-stenosis group [(14.21±1.02) μg/L, (23.11±1.08) μg/L, and (318.23±27.54) ng/L], with statistically significant differences (all P<0.05). The ROC analysis showed that serum levels of HMGB1, IL-1β, and TGF-β1 on the postoperative 7th day could be used as predictors for ureteral stenosis after holmium laser lithotripsy (Z=7.421, 2.759, and 10.740; all P<0.05), the area under the curve (AUC) was 0.848, 0.679, and 0.898, respectively, and serum TGF-β1 had the highest predictive efficiency.
ConclusionsUreteral injury caused by holmium laser lithotripsy can lead to the increases of serum HMGB1, IL-1β, and TGF-β1 levels. Patients' serum HMGB1, IL-1β, and TGF-β1 levels can be used as predictors for ureteral stricture after holmium laser lithotripsy.
Key words:
Epithelial-mesenchymal transition; Ureteral calculi; Holmium laser lithotripsy; Ureteral stricture
Contributor Information
Zheng Pengyi
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Zhang Yang
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Wang Xiaohui
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Li Huibing
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Li Wensheng
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Wang Kaixuan
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Huang Hua
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Lyu Shuangwu
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Han Qingjiang
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
Li Zhijun
Department of Urology, Clinical Medical College, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, China
