Review
Research progress in pathogenic mechanism of hemorrhagic shock-induced acute lung injury/acute respiratory distress syndrome
Wang Zhiwei, Zheng Ming, Wang Tianbing
Published 2020-10-15
Cite as Chin J Trauma, 2020, 36(10): 944-949. DOI: 10.3760/cma.j.cn501098-20200529-00389
Abstract
Hemorrhagic shock is hypovolemic shock caused by various blood loss which results in tissue and organ hypoperfusion. Accompanied by coagulation dysfunction, hypothermia, acidosis, inflammatory response and hemorrhagic shock can lead to multiple organ dysfunction syndrome and even be life-threatening. Lung is usually the most vulnerable organ and the first organ showing symptoms during hemorrhagic shock. Acute respiratory distress syndrome (ARDS) has a mortality rate around 40% following acute lung injury (ALI). Hemorrhagic shock-induced ALI/ARDS involves a series of pathophysiological processes, such as insufficient blood perfusion, cell damage, recruitment and infiltration of inflammatory cells and cytokine releasing. However, the underlying mechanisms are not yet completely clear. Based on the pulmonary endothelial and epithelial injury, inflammatory cell recruitment, and inflammatory response, the authors mainly review the recent advances in mechanisms of hemorrhagic shock-induced ALI/ARDS to provide references for clinical treatment and researches.
Key words:
Shock, hemorrhagic; Inflammation; Acute lung injury; Acute respiratory distress syndrome
Contributor Information
Wang Zhiwei
Trauma Medicine Center, Peking University People's Hospital
Key Laboratory of Trauma and Neural Regeneration (Peking University)
National Center for Trauma Medicine, Beijing 100044, China
Zheng Ming
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China
Wang Tianbing
Trauma Medicine Center, Peking University People's Hospital
Key Laboratory of Trauma and Neural Regeneration (Peking University)
National Center for Trauma Medicine, Beijing 100044, China