Liver Fibrosis•Cirrhosis
Diagnostic value of serum chitinase-3-like protein 1 in chronic liver disease of significant fibrosis and cirrhosis
Hong Li, Tong Yan, Zhen Zhu, Zuowei Bao, Tianmin Xu, Jing Xie, Shuqin Zheng, Manman Cui, Longgen Liu
Published 2018-05-20
Cite as Chin J Hepatol, 2018, 26(5): 337-341. DOI: 10.3760/cma.j.issn.1007-3418.2018.05.005
Abstract
ObjectiveTo study the correlation between the level of serum Chitinase-3-like protein 1 (CHI3L1) and the significant liver fibrosis and liver cirrhosis in patients with chronic liver disease, and to evaluate its diagnostic value.
Methods165 patients with chronic liver disease were selected, liver histopathological examination was performed to detect serum CHI3L1 concentration. Four indexes of hepatic fibrosis (type III procollagen, collagen IV, laminin, hyaluronic acid), aspartate aminotransferase/platelet ratio index (APRI) and FIB-4 (fibrosis- 4) scores were based on the pathological findings of liver biopsy and compared the advantages and disadvantages of serum CHI3L1 with other methods for the diagnosis of hepatic fibrosis and liver cirrhosis. A multivariate regression analysis model was created, and receiver operating characteristic curve was analyzed.
ResultsThe level of serum CHI3L1 increased with increase of fibrosis stage and was highest in liver cirrhosis stage. In the period of S0 to 1, the levels of S2 to 3 and S4 were 62.82 (41.40 ~ 87.20), 70.94 (48.47 to 122.60) and 141.06 (78.18 ~ 197.40), and there were statistically significant differences between the groups (P < 0.001). The area under the curve for the diagnosis of significant liver fibrosis was 0.68 (0.60 to 0.77), and 0.74 (0.65 to 0.83) for cirrhosis in CHI3L1. Multivariate regression analysis showed that CHI3L1 was an independent predictor of significant fibrosis and cirrhosis. The combined diagnostic model based on CHI3L1, collagen IV and FIB-4 scores further improved the diagnostic value. The area under the curve for the diagnosis of significant fibrosis and cirrhosis was 0.79 (0.72 to 0.86) and 0.80 (0.73 to 0.87), respectively.
ConclusionCHI3L1 has a good diagnostic value in patients with chronic liver disease with significant fibrosis and liver cirrhosis. The diagnostic model in combination with other markers like Collagen IV and FIB-4 scores could further improve the diagnostic value and is worthy of further study.
Key words:
Chronic liver disease; Liver cirrhosis; Chitinase-3-like protein 1
Contributor Information
Hong Li
Hepatology Department, Changzhou Third People's Hospital, Changzhou 213001, China
Tong Yan
Hepatology Department, Changzhou Third People's Hospital, Changzhou 213001, China
Zhen Zhu
Clinical Laboratory, Changzhou Third People's Hospital, Changzhou 213001, China
Zuowei Bao
Ultrasound Department, Changzhou Third People's Hospital, Changzhou 213001, China
Tianmin Xu
Infectious Disease Department, Changzhou Third People's Hospital, Changzhou 213001, China
Jing Xie
Hepatology Department, Changzhou Third People's Hospital, Changzhou 213001, China
Shuqin Zheng
Hepatology Department, Changzhou Third People's Hospital, Changzhou 213001, China
Manman Cui
Infectious Disease Department, Changzhou Third People's Hospital, Changzhou 213001, China
Longgen Liu
Hepatology Department, Changzhou Third People's Hospital, Changzhou 213001, China
