Review
Advances in the regulation of functions of hepatic stellate cells by exosomes
Ye Qiannan, Ping Jian, Xu Lieming
Published 2020-11-20
Cite as Chin J Hepatol, 2020, 28(11): 981-984. DOI: 10.3760/cma.j.cn501113-20190412-00123
Abstract
Exosomes are small vesicles with a bilayer membrane structure secreted by a variety of cells. They are widely distributed in a variety of body fluids and contain proteins, nucleic acids and other components. They can mediate information transmission between cells and participate in a variety of physiological and pathological activities of cells. Hepatocytes, hepatic sinus endothelial cells and other cells were able to communicate with hepatic stellate cells via exosomes, and regulate the activation, migration, apoptosis and other biological activities of hepatic stellate cells. In this review, the recent advances in the regulation of exosomes on the biological activity of hepatic stellate cells were reviewed.
Key words:
Exosomes; Hepatic stellate cells; Activation; Migration; Apoptosis; Autophagy
Contributor Information
Ye Qiannan
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Institute of Hepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Ping Jian
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China
Xu Lieming
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Institute of Hepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China
Shanghai Key Clinical Laboratory of Traditional Chinese Medicine, Shanghai 201203
