Liver Fibrosis·Cirrhosis
Risk factors and nutritional status analysis in patients with liver cirrhosis and concomitant chronic periodontitis
Sun Xianghui, Liang Jing, Wang Yonglan, Han Tao, Xu Shasha
Published 2021-08-20
Cite as Chin J Hepatol, 2021, 29(8): 748-753. DOI: 10.3760/cma.j.cn501113-20191015-00375
Abstract
ObjectiveTo study and explore the prevalence, characteristics, preliminary risk factors, as well as their relationship with nutritional scores in liver cirrhotic patient with chronic periodontitis.
Methods163 patients with liver cirrhosis who were hospitalized in the Hepatology Division, Department of Internal Medicine at Tianjin Third Central Hospital from June to September 2018 were enrolled as the case group, while the control group consisted 140 healthy individuals enrolled during the same period. Periodontal examination, biochemical examination and oral hygiene habits were investigated. The prevalence of periodontitis in the two groups was compared, and the risk factors of severe periodontitis were conducted by multivariate regression analysis.
ResultsThe prevalence of chronic periodontitis was significantly higher in patients with liver cirrhosis than healthy control population, and the differences were statistically significant (P < 0.05). The prevalence of severe periodontitis and full edentulous jaws was significantly higher in patients with liver cirrhosis than healthy control group, and the differences were statistically significant ( P < 0.05 and P < 0.001). Compared with the healthy control group, the depth of periodontal pocket and the degree of attachment loss were significantly increased in the liver cirrhosis group ( P < 0.001). Multivariate regression analysis showed that liver cirrhosis was the independent risk factors for both groups of patients with severe periodontitis (χ 2 = 11.046, P < 0.001). Univariate and multivariate regression analysis showed that toothbrushing frequency, nutritional risk score, prealbumin level and Child-Pugh grade were independent risk factors for occurrence of severe periodontitis in liver cirrhotic patient (χ 2 = 5.252, P = 0.022; χ 2 = 24.162, P < 0.001; χ 2 = 4.159, P = 0.041; χ 2 = 9.249, P = 0.002).
ConclusionThe prevalence of periodontitis is significantly higher in patients with liver cirrhosis than healthy individuals, and liver cirrhosis is an independent risk factor for the occurrence of severe periodontitis. Toothbrushing frequency, nutritional risk score, prealbumin level and Child-Pugh grade are risk factors for severe periodontitis in patients with liver cirrhosis.
Key words:
Liver cirrhosis; Chronic periodontitis; Attachment loss; Periodontal pocket depth; Nutritional risk score
Contributor Information
Sun Xianghui
Department of Stomatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China
Liang Jing
Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China
Wang Yonglan
College of Dentistry, Tianjin Medical University, Tianjin 300070, China
Han Tao
Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China
Xu Shasha
Department of Stomatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China
