Review
The mechanisms of the translation of polymerase from HBV pregenomic RNA
Lu Danjuan, Zheng Huiling, Xi Jingyuan, Zhang Ting, Chen Xiangmei, Lu Fengmin
Published 2021-10-20
Cite as Chin J Hepatol, 2021, 29(10): 1035-1040. DOI: 10.3760/cma.j.cn501113-20210808-00384
Abstract
Hepatitis B virus (HBV) is an important pathogen that causes different liver diseases such as viral hepatitis and liver cirrhosis. HBV pregenomic RNA (pgRNA) plays a crucial role in HBV life cycle, which is not only the translation template of core (C) and polymerase (P), but also the template of reverse transcription. The ratio of P protein to core protein is tightly regulated. Since P and core are both translated by pgRNA and the open reading frame (ORF) of P is located downstream of the ORF of core, how to initiate P protein translation is a key scientific question. Previous studies suggest that P can be translated through different mechanisms, such as leaky scanning and reinitiation. In this review, we summarized the proposed mechanisms relevant to the translation of polymerase from HBV pgRNA through literature review and derivation.
Key words:
Hepatitis B virus; Pregenomic RNA; Polymerase; Selective translation
Contributor Information
Lu Danjuan
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Zheng Huiling
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Xi Jingyuan
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Zhang Ting
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Chen Xiangmei
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Lu Fengmin
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China
Peking University People’s Hospital, Peking University Hepatology Institute, Beijing 100044, China
