Brief Report
Correlational verification of drug-induced liver injury with HLA-B*35:01 allele due to Polygonum multiflorum
Huang Deliang, Li Chaopeng, Wang Jiabo, Luo Fang, Chen Zhijie, Zhu Zhibin, Lai Huiyi, Cai Qingxian, Chen Jun
Published 2021-11-20
Cite as Chin J Hepatol, 2021, 29(11): 1106-1108. DOI: 10.3760/cma.j.cn501113-20210702-00312
Abstract
In order to verify the correlation between Polygonum multiflorum-induced liver injury and HLA-B*35 : 01 alleles, six hospitalized patients diagnosed with Polygonum multiflorum-induced liver injury (PM-DILI) were selected, and their clinicopathological data were collected. Simultaneously, blood HLA-B* 35 : 01 allele detection was performed. Among the six PM-DILI cases, 4 were male, aged 38.83 ± 10.13 years old. The types of liver injury were hepatocellular injury types in all, and the severity of liver injury in five cases was grade 3. The histological presentations were acute hepatitis and acute cholestatic hepatitis. PM-DILI cases were all HLA-B*35:01 carriers, with a carrier rate of 100%. This finding indicates that PM-DILI is significantly correlated with HLA-B*35:01 alleles. Therefore, HLA-B*35 : 01 alleles can be used as an important predictive indicator for PM-DILI.
Key words:
Fleeceflower root (He-shou-wu); Drug-induced liver injury; Susceptible population; HLA-B*35:01; Verification; Prediction
Contributor Information
Huang Deliang
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Li Chaopeng
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410000, China
Wang Jiabo
The Fifth Medical Center, General Hospital of PLA, Beijing 100000, China
Luo Fang
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Chen Zhijie
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Zhu Zhibin
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Lai Huiyi
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Cai Qingxian
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
Chen Jun
Department of Liver Diseases, The Third People’s Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518100, China
