Autologous split-thickness skin grafting is still an important procedure for the repair of skin defect. However, there are some obvious limitations, such as new injury to skin donor sites and insufficient skin source, etc. It is an ideal goal to develop tissue-engineered skin to realize permanent replacement of skin defect. After decades of development, a variety of tissue-engineered skins have been put into the market for applications, but it is still a long way to achieve regenerative repair of skin defect. In this article, we summarize the status of various tissue-engineered skins, and then make a preliminary discussion on the opportunities and challenges on development of tissue-engineered skin.