Population Genetics
Genetic polymorphisms of 23 autosomal short tandem repeat loci among ethnic Han Chinese from southern China
Zhang Yaqing, Yang Chao, Chen Sen, Zhang Ying’ai
Published 2019-02-10
Cite as Chin J Med Genet, 2019, 36(2): 171-174. DOI: 10.3760/cma.j.issn.1003-9406.2019.02.020
Abstract
ObjectiveTo study genetic polymorphisms of 23 autosomal short tandem repeat (STR) loci among ethnic Han Chinese from southern China.
MethodsThe 23 autosomal STR loci among 331 unrelated healthy Han Chinese from southern China were genotyped with fluorescent multiplex amplification and capillary electrophoresis. Genetic parameters were subjected to statistical analysis.
ResultsIn total 265 alleles and 890 genotypes were detected for the 23 STR loci. The numbers of alleles were 5-22, allelic frequency was 0.0015-0.5483, heterozygosity (H) was 0.5891-0.9124, power of discrimination (DP) was 0.7818-0.9831, polymorphic information content (PIC) was 0.5425-0.9031, probability of exclusion for trio-paternity testing (PEt) was 0.2780-0.8208, and probability of exclusion for duo-paternity testing (PEd) was 0.193-0.693. The combined power of discrimination (CPD) was over 0.999 999 999 999 99, the combined probability of exclusion for trio-paternity identification (CPEt) was 0.999 999 999 729 813, and the combined probability of exclusion for duo-paternity identification (CPEd) was 0.999 999 207 508 474, respectively. The 23 STR loci showed no significant deviation from Hardy-Weinberg disequilibrium after Bonferroni correction (P>0.05).
ConclusionThe 23 autosomal STR loci were highly polymorphic among ethnic Han Chinese from southern China, which showed a high efficiency for paternity testing, personal identification and population genetics.
Key words:
Forensic genetics; Genetic polymorphism; Short tandem repeat; Ethnic Han Chinese; Southern China
Contributor Information
Zhang Yaqing
Institute of Blood Transfusion, Blood Center of Hainan Province, Haikou, Hainan 570311, China
Yang Chao
Public Security Bureau of Changshu, Changshu, Jiangsu 215500, China
Chen Sen
Forensic Science Center, Public Security Bureau of Panyu, Guangzhou, Guangdong 511400, China
Zhang Ying’ai
Central Laboratory, Haikou People’s Hospital, Haikou, Hainan 570208, China
