Review
Progress of research on chromosomal mosaicism embryos
Hu Zhixin, Chen Kexin, Li Yonggang, Yan Jiacong
Published 2023-05-10
Cite as Chin J Med Genet, 2023, 40(5): 618-623. DOI: 10.3760/cma.j.cn51137420220727-00496
Abstract
Chromosomal mosaicism (CM) is a common phenomenon in preimplantation genetic testing (PGT). In embryos with CM, genetic contents of trophoblastic ectodermal (TE) cells may be different from that of the inner cell mass (ICM) which will develop into the fetus. Embryos with low mosaic proportion could give rise to healthy live births after transplantation, but are accompanied with high pregnancy risks such as high abortion rate. In order to provide a more comprehensive understanding for CM embryos, this article has systematically summarized the recent progress of research on the definition, mechanism, classification, PGT techniques, self-correction mechanism, transplantation outcome and treatment principles for CM embryos.
Key words:
Chromosomal mosaicism embryo; Preimplantation genetic testing; Embryo transfer; Self-correction; Pregnancy outcome; Female
Contributor Information
Hu Zhixin
The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, China
Reproductive Medical Center, the First People′s Hospital of Yunnan Province, Kunming, Yunnan 650034, China
Chen Kexin
The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, China
Reproductive Medical Center, the First People′s Hospital of Yunnan Province, Kunming, Yunnan 650034, China
Li Yonggang
The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, China
Reproductive Medical Center, the First People′s Hospital of Yunnan Province, Kunming, Yunnan 650034, China
NHC Key Laboratory of Periconception Health Birth in Western China, Kunming, Yunnan 650021, China
Yan Jiacong
The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, China
Reproductive Medical Center, the First People′s Hospital of Yunnan Province, Kunming, Yunnan 650034, China
NHC Key Laboratory of Periconception Health Birth in Western China, Kunming, Yunnan 650021, China
