The efficacy of half-dose photodynamic therapy for acute central serous chorioretinopathy by enhanced deep imaging of optical coherence tomography
Zhang Caiyun, Mao Jianbo, Shen Lijun, Shao Yirun, Lin Jingjing, Lao Jimeng, Zheng Zicheng, Liu Bowen
Published 2020-09-25
Cite as Chin J Ocul Fundus Dis, 2020, 36(9): 702-706. DOI: 10.3760/cma.j.cn511434-20190704-00213
Abstract
ObjectiveTo observe the clinical efficacy of half-dose photodynamic therapy (PDT) in the treatment of acute central serous chorioretinopathy (CSC) by enhanced deep imaging-OCT (EDI-OCT).
MethodsA retrospective case study. From September 2015 to November 2018, 100 patients with acute CSC who received half-dose PDT in Hangzhou Branch of the Eye Optometry Hospital of Wenzhou Medical University were included in the study. Among 100 patients, 69 patients were males and 31 patients were females; the average age was 49.63±7.97 years; the average duration of disease was 2.19±0.71 months. All patients underwent BCVA, EDI-OCT, FFA, ICGA and other examinations. BCVA was used on the international standard visual acuity chart and converted to logMAR visual acuity records. Before treatment, the average logMAR BCVA was 0.29±0.19, the average macular foveal retinal thickness (CMT) was 370.59±134.98 μm, and the average macular subfoveal choroidal thickness (SFCT) was 366.93±86.95 μm. All patients were treated with half-dose PDT. We compared the changes of BCVA, CMT, SFCT, and subretinal fluid (SRF) of the eye before treatment and 2 weeks after treatment and 1, 3, and 6 months. Pearson correlation analysis method was used to analyze the correlation between BCVA and baseline BCVA, CMT, SFCT after 6 months of treatment.
ResultsSix months after treatment, SRF was completely absorbed in 98 eyes, with an effective rate of 98.0%. Compared with before treatment, 2 weeks and 1, 3, and 6 months after treatment, the BCVA of the eye significantly increased (F=66.493, P<0.001), and CMT and SFCT significantly decreased (F=134.625, 30.394; P<0.001,<0.001). The results of Pearson correlation analysis showed that BCVA was positively correlated with baseline BCVA 6 months after treatment (r=0.529, P<0.001), and there was no significant correlation with CMT and SFCT. There were no serious complications related to treatment during the follow-up period.
ConclusionsHalf-dose PDT can effectively increase BCVA in a short period of time for acute CSC. EDI-OCT can observe that CMT, SFCT and SRF absorption are significantly reduced after treatment.
Key words:
Central serous chorioretinopathy/therapy; Photochemotherapy; Tomography, optical coherence
Contributor Information
Zhang Caiyun
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Mao Jianbo
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Shen Lijun
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Shao Yirun
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Lin Jingjing
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Lao Jimeng
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Zheng Zicheng
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
Liu Bowen
Eye Hospital Wenzhou Medical University, Hangzhou 310000, China
