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ENGLISH ABSTRACT
Cariostat龋易感性检测技术用于评价3岁儿童患龋风险的研究
玄松玉
袁峻伟
王珏
关雪琳
葛立宏
下野勉
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1002-0098.2017.11.004
A 2-year cohort study on the caries risk assessment of 3-year-old caries-free children using Cariostat caries activity test
Xuan Songyu
Yuan Junwei
Wang Jue
Guan Xuelin
Ge Lihong
Shimono Tsutomu
Authors Info & Affiliations
Xuan Songyu
Stomatology Center of Peking University Hospital, Beijing 100871, China
Yuan Junwei
Stomatology Center of Peking University Hospital, Beijing 100871, China
Wang Jue
Stomatology Center of Peking University Hospital, Beijing 100871, China
Guan Xuelin
Stomatology Center of Peking University Hospital, Beijing 100871, China
Ge Lihong
Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
Shimono Tsutomu
Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Mediacine, Dentistry and Pharmaceutical Sciences 2-5-1, Shikata-Cho, Okayama City 700-8525, Japan
·
DOI： 10.3760/cma.j.issn.1002-0098.2017.11.004
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摘要

目的评价Cariostat龋易感检测技术用于评估3岁无龋儿童患病风险的准确性和有效性，为临床提供参考。

方法以北京市海淀区2所幼儿园2013年9月入园的所有3岁儿童为研究对象，家长签署知情同意书的儿童都接受了龋病患病状况检查和Cariostat龋易感性检测。对无龋儿童纵向追踪2年，观察儿童龋病的发病情况。比较高（龋态值为2.0、2.5、3.0）、中（龋态值为1.5）、低（龋态值为0、0.5、0.0）龋态值组3岁无龋儿童2年患龋率和龋病患病程度间的差异，评价Cariostat龋易感性检测技术用于患龋风险评价的有效性和准确性。

结果2013年2所幼儿园864名3岁儿童中无龋儿童共426名（49.3%），426名无龋儿童中共312名（73.2%）儿童完成2年的纵向观察，结果显示2年患龋率为46.5%（145/312）。高龋态值组无龋儿童2年患龋率为88.9%（88/99）；低龋态值组无龋儿童2年患龋率为17.5%（21/120）。以3岁时无龋儿童的龋态值为评估指标，预测儿童未来2年患龋的灵敏度为60.7%，特异度为93.4%。

结论Cariostat龋易感性检测技术用于3岁无龋儿童可有效预测儿童的患龋风险，该检测技术可用于儿童口腔健康综合管理。

龋病易感性;龋齿;牙，乳;龋态值
ABSTRACT

ObjectiveTo evaluate the caries status of a cohort of 3-year-old caries-free children from 2 kindergartens in Beijing in a period of 2 years by using Cariostat caries activity test and to assess the sensitivity and specificity of Cariostat score as a caries risk indicator for caries-free children.

MethodsTotally 426 3-year-old caries-free children from 2 kindergartens in Beijing were recruited in the present study. Informed consents were obtained from the children's parents. Dental plaque samples of the children were collected and the Cariostat caries activity tests were conducted at baseline and once a year for 2 years. After two years, the caries status of the cohort children were re-evaluated and the caries incidences amongst children with high (2.0, 2.5, 3.0), medium (1.5) and low (1.0, 0.5, 0.0) levels of Cariostat scores were compared and analyzed.

ResultsTotally 864 3-year-old children from 2 kindergartens were screened before the study startedand 426 (49.3%) children were caries free. After 2-year follow-up, 312 out of 426 (73.2%) remained in the study. The overall caries incident rate was 46.5% (145/312). The caries incident rate of children with high level of Cariostat scores was 88.9% (88/99), while the caries incident rates of children with medium and low levels of Cariostat scores was 38.7% (36/93) and 17.5% (21/120), respectively. The sensitivity and specificity of the Cariostat test in assessing the caries risk of 3-year-old caries-free children in a period of 2 years were 60.7% and 93.4%, respectively.

ConclusionsCariostat caries activity test can be used as an indicator to predict the caries risk of 3-year-old caries-free children. Comprehensive caries management could be conducted for children in kindergartens based on the caries risk assessment results of caries experience and the Cariostat score.

Dental caries susceptibility;Dental caries;Tooth, deciduous;Cariostat score
Guan Xuelin, Email: mocdef.aabnisepullooc, Tel: 0086-10-62754203
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引用本文

玄松玉,袁峻伟,王珏,等. Cariostat龋易感性检测技术用于评价3岁儿童患龋风险的研究[J]. 中华口腔医学杂志,2017,52(11)：667-671.

DOI:10.3760/cma.j.issn.1002-0098.2017.11.004

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我国儿童乳牙患龋率高，患病程度重。王文红等 [ 1 ]研究显示，儿童从1岁起患龋率直线上升，2岁儿童患龋率为31.09%，3岁时为48.33%，北京市5岁儿童的患龋率高达64.10%。寻找一种简单、可靠的儿童患龋风险评估手段是口腔医师一直探索的课题。
Cariostat龋易感性检测法由日本下野勉教授于20世纪70年代创建 [ 2 , 3 , 4 , 5 ]，可预测儿童患龋风险，检查结果准确，操作方便安全，具有重复性好的特点，已应用于口腔临床、健康体检及口腔保健教育工作中。但受限于进口试剂的价格及渠道，无论是在临床持续应用及群体筛查工作应用均受到很大限制。本研究采用改进后的Cariostat龋易感性检测试剂检测受检儿童的龋易感性。
Cariostat龋易感性检测试剂以蔗糖为碳源，蛋白质为营养源，溴甲苯酚为酸碱显色剂，经48 h的恒温培养，通过观察颜色变化，检测牙齿表面产酸菌的产酸能力，测定机体对龋病的敏感度 [ 2 , 3 , 4 , 5 , 6 , 7 ]。龋病是在致龋菌、遗传和环境因素共同作用下发生 [ 8 , 9 ]，乳牙列时期的口腔检查不是单纯的龋坏牙数的检查，还应通过患龋风险分析，预防龋齿的发生。本研究以Cariostat龋易感性检测技术评价3岁无龋儿童患龋风险并进行2年追踪研究，以期评价Cariostat龋易感性检测技术用于龋病风险评估的可行性、准确性和有效性，为临床提供参考。
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参考文献
[1]
王文红，苗江霞，邹晓璇,等. 北京市海淀区2010年1~5岁儿童乳牙龋病抽样调查报告[J]. 中国儿童保健杂志, 2015,23(5):545-547. DOI: 10.11852/zgetbjzz2015-23-05-31 .
返回引文位置Google Scholar
百度学术
万方数据
Wang WH , Miao JX , Zou XX ,et al. Sample survey of primary teeth caries among 1-5 years old children in Haidian district, Beijing city, 2010[J]. Chin J Child Health Care, 2015,23(5):545-547. DOI: 10.11852/zgetbjzz2015-23-05-31 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[2]
Shimono T . A new colorimetric caries activity test[J]. Dental Outlook, 1974,43(6):829-835.
返回引文位置Google Scholar
百度学术
万方数据
[3]
Shimono T. Application of a new colorimetric caries activity test (Cariostat). Dental Outlook, 1975, 42: 941-948.
返回引文位置
[4]
Shimono T , Matsumura S . Colorimetric caries activity test[J]. J Dental Hygiene, 1982,2(6):558-567.
返回引文位置Google Scholar
百度学术
万方数据
[5]
Okazaki H, Matsumura S, Shimono T. Effetive use of colorimetric caries activity test (CAT21Test·CAT21Buf). Jpn J Clin Dent Child, 2002, 17(9): 67-84.
返回引文位置
[6]
Shimono T, Mjzuno J, Nonomura E, et al. Studies on a caries activity test (Cariostat comparison with Snyder test). Jpn J Ped Dent, 1980, 18: 612-617.
返回引文位置
[7]
李静，秦满，谢盼. 北京市幼儿园3~4岁儿童龋齿活动性研究[J]. 现代口腔医学杂志, 2006,20(6):640-642. DOI: 10.3969/j.issn.1003-7632.2006.06.026 .
返回引文位置Google Scholar
百度学术
万方数据
Li J , Qin M , Xie P . A study on caries activity in Beijing children aged 3-4 years old[J]. J Modern Stomatol, 2006,20(6):640-642. DOI: 10.3969/j.issn.1003-7632.2006.06.026 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[8]
苗江霞，李文珺，张艳玲,等. 北京市海淀区3岁儿童婴幼儿龋患病率调查及相关因素分析[J]. 中国儿童保健杂志, 2011,19(11):1040-1042.
返回引文位置Google Scholar
百度学术
万方数据
Miao JX , Li WJ , Zhang YL ,et al. Epidemiological investigation of early childhood caries and the correlative factors, analysis for 3 years old children in the Haidian district in Beijing[J]. Chin J Child Health Care, 2011,19(11):1040-1042.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[9]
Anderson M . Risk assessment and epidemiology of dental caries: review of the literature[J]. Pedistr Dent, 2002,24(5):377-385.
返回引文位置Google Scholar
百度学术
万方数据
[10]
Tanaka K , Okazaki Y , Higashi T ,et al. The relationship between the caries activity test (Cariostat) and the status of dental caries from infans to school children[J]. J Ped Dent, 1999,37(3):605-610.
返回引文位置Google Scholar
百度学术
万方数据
[11]
袁峻伟，玄松玉，王珏,等. 北京市海淀区3岁儿童龋病患病状况及龋病活跃性检测的研究[J]. 北京口腔医学, 2017,25(3):166-168.
返回引文位置Google Scholar
百度学术
万方数据
Yuan JW , Xuan SY , Wang J ,et al. The cohort study on caries prevalence and caries activity test among 3-year-old children in Haidian district of Beijing[J]. Beijing J Stomatol, 2017,25(3):166-168.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[12]
World Health Organization. Oral health survey: basic methods[M]. 4th ed. Geneva:World Health Organization, 1997.
返回引文位置
[13]
邓辉，徐征. 北京市1~4岁儿童龋流行情况调查及其危险因素的初步研究[J]. 现代口腔医学杂志, 2006,20(4):418-421. DOI: 10.3969/j.issn.1003-7632.2006.04.026 .
返回引文位置Google Scholar
百度学术
万方数据
Deng H , Xu Z . A primary study of early childhood caries and risk factors for 1 to 4-year-old children in Beijing[J]. J Modern Stomatol, 2006,20(4):418-421. DOI: 10.3969/j.issn.1003-7632.2006.04.026 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[14]
董玉杰. 长春市3岁儿童龋流行情况及其危险因素分析[J]. 中国妇幼保健, 2015,30(33):5860-5861. DOI: 10.7620/zgfybj.j.issn.1001-4411.2015.33.53 .
返回引文位置Google Scholar
百度学术
万方数据
Dong YJ . Prevalence and risk factors of caries among 3-year-old children in Changchun[J]. Maternal Child Health Care China, 2015,30(33):5860-5861. DOI: 10.7620/zgfybj.j.issn.1001-4411.2015.33.53 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[15]
北京市人民政府. 北京市2013年度卫生与人群健康状况报告. 北京:人民卫生出版社, 2014:28-29.
返回引文位置
Beijing municipal people's government. Report on health and population health in Beijing 2013[M]. Beijing:People's Medical Publishing House, 2014:28-29.
Goto Citation
[16]
刘敏，石一谷，王鹏,等. 2013年北京市3~5岁儿童乳牙龋病患病状况调查报告[J]. 北京口腔医学, 2015,23(5):282-287.
返回引文位置Google Scholar
百度学术
万方数据
Liu M , Shi YG , Wang P ,et al. A survey of the early childhood caries in 3-5 years children in Beijing 2013[J]. Beijing J Stomatol, 2015,23(5):282-287.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[17]
苗江霞，王文红，邹晓璇,等. 0~2岁儿童重症婴幼儿龋危险因素分析[J]. 中国妇幼卫生杂志, 2015, (4):5-8.
返回引文位置Google Scholar
百度学术
万方数据
Miao JX , Wang WH , Zou XX . Analysis of severe early childhood caries risk factors among 0-2 years old children[J]. Chin J Women Child Health, 2015, (4):5-8.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[18]
高承志，李红梅，梁勤,等. 北京地区学龄前儿童龋活跃性的研究分析[J]. 现代口腔医学杂志, 2005,19(1):94-95. DOI: 10.3969/j.issn.1003-7632.2005.01.033 .
返回引文位置Google Scholar
百度学术
万方数据
Gao CZ , Li HM , Liang Q ,et al. Study on caries activity of preschool children in Beijing[J]. J Modern Stomatol, 2005,19(1):94-95. DOI: 10.3969/j.issn.1003-7632.2005.01.033 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[19]
周艳，洪建萍，陈华清. 深圳地区学龄前儿童龋活跃性的研究分析[J]. 牙体牙髓牙周病学杂志, 2011,21(3):172-174.
返回引文位置Google Scholar
百度学术
万方数据
Zhou Y , Hong JP , Chen HQ . Study on caries activity of preschool children[J]. Chin J Conserv Dent, s 2011,21(3):172-174.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[20]
夏斌，秦满，韩烨,等. 儿童口腔科门诊治疗要求特征分析及对策[J]. 北京大学学报:医学版, 2013,45(1):92-96.
返回引文位置Google Scholar
百度学术
万方数据
Xia B , Qin M , Han Y ,et al. Children stomatology outpatient treatment requirements analysis and countermeasures[J]. J Peking Univ: Health Sci, 2013,45(1):92-96.
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
备注信息
A
关雪琳，Email: mocdef.aabnisepullooc,电话: 010-62754203
B

玄松玉、袁峻伟、王珏：提出研究课题、设计实施、数据的获取与分析、论文撰写；关雪琳、葛立宏、下野勉：论文指导

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