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ENGLISH ABSTRACT
近视眼角膜生物力学特性与角膜高阶像差的相关性
张耀花
王雁
窦瑞
危平辉
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2018.05.009
Correlation analysis between corneal biomechanical properties and high-order aberration in myopia
Zhang Yaohua
Wang Yan
Dou Rui
Wei Pinghui
Authors Info & Affiliations
Zhang Yaohua
Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, NanKai University, Tianjin Medical University, Clinical College of Ophthalmology, Tianjin 300020, China
Wang Yan
Dou Rui
Wei Pinghui
·
DOI： 10.3760/cma.j.issn.2095-0160.2018.05.009
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摘要

目的探讨近视患者角膜生物力学特性与角膜高阶像差(HOAs)的相关性。

方法采用回顾性病例观察研究。收集2015年1—10月在天津市眼科医院屈光手术中心就诊的近视及近视散光患者263例263眼的病例资料，均取右眼进行分析。应用可视化角膜生物力学分析仪(Corvis ST)对患者的角膜形变参数，包括第1次压平时间(A1T)、第1次压平长度(A1L)、第1次压平速度(A1V)、第2次压平时间(A2T)、第2次压平长度(A2L)、第2次压平速度(A2V)、产生最大压陷的时间(HCT)、最大压陷时的变形幅度(HCDA)、最大压陷时的峰距(HCPD)、最大压陷时的反向曲率半径(HCR)和非接触式眼压(IOPnct)等进行测量和分析；应用Pentacam眼前节分析系统测量中央角膜厚度(CCT)和6 mm直径范围的角膜前表面、后表面和全角膜垂直彗差、水平彗差、 y向三叶草像差、 x向三叶草像差、初级球差、总均方根(总RMS)、HOAs均方根(HOAs RMS)等HOAs。应用Pearson线性相关分析和多元逐步线性回归模型进行数据分析。

结果近视眼的角膜生物力学特性与角膜HOAs间存在相关性；A1L与角膜前表面的初级球差、HOAs RMS，后表面的总RMS、HOAs RMS以及全角膜的HOAs RMS间均呈负相关(均 P<0.05)；HCR与角膜前表面、全角膜总RMS均呈负相关(均 P<0.05)。A2V与多种像差均相关。多元逐步线性回归模型分析显示，角膜前表面像差和全角膜像差与角膜生物力学参数间的相关性较弱，角膜后表面像差与角膜生物力学参数间的相关性相对较强。

结论近视眼的角膜生物力学特性与角膜HOAs间存在相关性，角膜生物力学特性的变化主要与角膜后表面像差相关联，其或许有助于我们对早期圆锥角膜或扩张性角膜疾患的早期诊断。

角膜生物力学特性;像差;视觉质量
ABSTRACT

ObjectiveTo investigate the correlations between corneal biomechanical properties and corneal high-order aberrations (HOAs) in myopic eyes.

MethodsIn this retrospective study, 263 right eyes with myopia or myopic astigmatism were enrolled from January to October 2015 in Tianjin Eye Hospital.The values of first applanation time (A1T), first applanation length (A1L), first applanation velocity (A1V), second applanation time (A2T), second applanation length (A2L), second applanation velocity (A2V), highest concavity time (HCT), highest concavity deformation amplitude (HCDA), highest concavity peak distance (HCPD), highest concavity radius (HCR) and non-contact intraocular pressure (IOPnct) were measured using the corneal visualization Scheimpflug technology (Corvis ST). The central corneal thickness (CCT) and wavefront aberrations of the anterior, posterior surface, and the total cornea were measured with Pentacam.Pearson correlation and stepwise multivariate linear regression analysis were applied to analyze the correlations between biomechanical properties and corneal HOAs.This study follows the Helsinki declaration.The experiment was approved by the Ethic Committee of Tianjin Eye Hospital.Informed consent was signed from each patient.

ResultsThere was a correlation between biomechanical properties and corneal HOAs.Negative correlations were found between A1L and the spherical aberration, HOAs RMS of anterior surface, total RMS and HOAs RMS of the posterior surface and HOAs RMS of the total cornea ( P<0.05). HCRs were negatively correlated with total RMS of the total cornea and the anterior surface ( P<0.05). The A2V was correlated with various aberrations.Multiple stepwise linear regression model analysis showed that, the correlation between the aberrations of anterior surface and biomechanical parameters, and the correlations between the total corneal aberration and biomechanical parameters were weak, the correlations between the aberrations of posterior surface and biomechanical parameters were strong.

ConclusionsThere is a correlation between the biomechanical properties and corneal HOAs.The changes of the corneal biomechanical properties are mainly associated with the posterior corneal aberrations, which may contribute to the early diagnosis of subclinical keratoconus or dilated corneal disease.

Corneal biomechanical properties;Aberration;Visual quality
Wang Yan, Email: mocdef.aabnis.piv3417naygnaw
National Natural Science Foundation of China (81670884, 81470658)
Copyright by Chinese Medical Association
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引用本文

张耀花,王雁,窦瑞,等. 近视眼角膜生物力学特性与角膜高阶像差的相关性[J]. 中华实验眼科杂志,2018,36(5)：368-372.

DOI:10.3760/cma.j.issn.2095-0160.2018.05.009

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随着屈光手术的逐步发展，如今的角膜屈光手术具有良好的安全性、有效性和长期稳定性 [ 1 ]，使得越来越多的人选择其来矫正视力，然而术后暗视力下降、眩光、光晕等视觉质量问题也随之而来。研究显示，波前像差与视觉质量密切相关 [ 2 ]。角膜组织是生物黏弹性材料，其生物力学特性是维持角膜正常形态的基础；而角膜像差由角膜的自身的形状以及表面存在的不规则性所决定，有研究表明，部分像差与中央角膜厚度(corneal central thickness，CCT)存在相关性 [ 3 ]，角膜像散和球差与眼压间也有明显的相关性 [ 3 , 4 , 5 ]，提示我们角膜像差可能与其生物力学特性有关。目前，近视眼角膜生物力学特性与高阶像差(high-order aberrations，HOAs)的关系尚不清楚。本研究对近视眼角膜生物力学特性和HOAs的相关性进行探讨。
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参考文献
[1]
Blum M , Flach A , Kunert KS ，et al. Five-year results of refractive lenticule extraction[J]．J Cataract Refract Surg， 2014，40(9)∶1425-1429. DOI： 10.1016/j.jcrs.2014.01.034 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Maeda N ．Wavefront technology in ophthalmology[J]．Curr Opin Ophthalmol， 2001，12(4)∶294-299.
返回引文位置Google Scholar
百度学术
万方数据
[3]
Qu J , Lu F , Wu J ，et al. Wavefront aberration and its association with intraocular pressure and central corneal thickness in myopic eyes[J]．J Cataract Refract Surg， 2007，33(8)∶1447-1454. DOI： 10.1016/j.jcrs.2007.04.012 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Mierdel P , Krinke HE , Pollack K ，et al. Diurnal fluctuation of higher order ocular aberrations：correlation with intraocular pressure and corneal thickness[J]．J Refract Surg， 2004，20(3)∶236-242.
返回引文位置Google Scholar
百度学术
万方数据
[5]
Ninn-Pedersen K ．Relationships between preoperative astigmatism and corneal optical power，axial length，intraocular pressure，gender，and patient age[J]．J Refract Surg， 1996，12(4)∶472-482.
返回引文位置Google Scholar
百度学术
万方数据
[6]
魏升升，李勇，李晶，等．圆锥角膜与健康角膜生物力学的对比研究[J]．中华眼科杂志， 2016，52(9)∶669-673. DOI： 10.3760/cma.j.issn.0412-4081.2016.09.007 .
返回引文位置Google Scholar
百度学术
万方数据
Wei SS , Li Y , Li J ，et al. Corneal biomechanical properties in keratoconic and normal eyes[J]．Chin J Ophthalmol 2016，52(9)∶669-673. DOI： 10.3760/cma.j.issn.0412-4081.2016.09.007 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[7]
王雁．波前像差与临床视觉矫正[M]．北京：人民卫生出版社， 2011∶109-118.
返回引文位置
[8]
Nemeth G , Hassan Z , Szalai E ，et al. Analysis of age-dependence of the anterior and posterior cornea with scheimpflug imaging[J]．J Refract Surg， 2013，29(5)∶326-331. DOI： 10.3928/1081597X-20130301-01 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Liang J , Williams DR . Aberrations and retinal image quality of the normal human eye[J]．J Opt Soc Am A Opt Image Sci Vis， 1997，14(11)∶2873-2883.
返回引文位置Google Scholar
百度学术
万方数据
[10]
侯杰，王雁，耿维莉，等．近视眼角膜前、后表面不同范围非球面性及其与角膜球差的关系[J]．中华眼视光学与视觉科学杂志， 2012，14(6)∶352-356. DOI： 10.3760/cma.j.issn.1674-845X.2012.06.008 .
返回引文位置Google Scholar
百度学术
万方数据
Hou J , Wang Y , Geng WL ，et al. Relationship between asphericity and spherical aberration of the human cornea with different corneal diameters[J]．Chin J Optom Ophthalmol Vis Sci， 2012，14(6)∶352-356. DOI： 10.3760/cma.j.issn.1674-845X.2012.06.008 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[11]
Wu W , Wang Y ．The correlation analysis between corneal biomechanical properties and the surgically induced corneal high-order aberrations after small incision lenticule extraction and femtosecond laser in situ keratomileusis[J/OL]．J Ophthalmol， 2015，2015∶758196[2017－03－13]．https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592923/. DOI： 10.1155/2015/758196 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
王雁．重视更新视觉新理念以不断提升角膜屈光手术后视觉质量[J]．中华眼科杂志， 2016，52(1)∶10-14. DOI： 10.3760/cma.j.issn.0412-4081.2016.01.005 .
返回引文位置Google Scholar
百度学术
万方数据
Wang Y ．Update the concepts on visual correction and enhance the visual quality after corneal refractive surgery[J]．Chin J Ophthalmol， 2016，52(1)∶10-14. DOI： 10.3760/cma.j.issn.0412-4081.2016.01.005 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[13]
Wang L , Dai E , Koch DD ，et al. Optical aberrations of the human anterior cornea[J]．J Cataract Refract Surg， 2003，29(8)∶1514-1521.
返回引文位置Google Scholar
百度学术
万方数据
[14]
刘丽清，王雁，杨福利，等．近视眼角膜高阶像差的特征及影响因素[J]．中华眼视光学与视觉科学杂志， 2012，14(10)∶592-596. DOI： 10.3760/cma.j.issn.1674-845X.2012.10.005 .
返回引文位置Google Scholar
百度学术
万方数据
Liu LQ , Wang Y , Yang FL ，et al. An investigation on the characteristics and related factors of corneal higher-order aberration[J]．Chin J Optom Ophthalmol Vis Sci， 2012，14(10)∶592-596. DOI： 10.3760/cma.j.issn.1674-845X.2012.10.005 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[15]
Bühren J , Kook D , Yoon G ，et al. Detection of subclinical keratoconus by using corneal anterior and posterior surface aberrations and thickness spatial profiles[J]．Invest Ophthalmol Vis Sci， 2010，51(7)∶3424-3432. DOI： 10.1167/iovs.09-4960 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Reddy JC , Rapuano CJ , Cater JR ，et al. Comparative evaluation of dual Scheimpflug imaging parameters in keratoconus，early keratoconus，and normal eyes[J]．J Cataract Refract Surg， 2014，40(4)∶582-592. DOI： 10.1016/j.jcrs.2013.08.061 .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Ali NQ , Patel DV , McGhee CN . Biomechanical responses of healthy and keratoconic corneas measured using a noncontact scheimpflug-based tonometer[J]．Invest Ophthalmol Vis Sci， 2014，55(6)∶3651-3659. DOI： 10.1167/iovs.13-13715 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Galletti JG , Pförtner T , Bonthoux FF . Improved keratoconus detection by ocular response analyzer testing after consideration of corneal thickness as a confounding factor[J]．J Refract Surg， 2012，28(3)∶202-208. DOI： 10.3928/1081597X-20120103-03 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Piñero DP , Alió JL , Alesón A ，et al. Corneal volume，pachymetry，and correlation of anterior and posterior corneal shape in subclinical and different stages of clinical keratoconus[J]．J Cataract Refract Surg， 2010，36(5)∶814-825. DOI： 10.1016/j.jcrs.2009.11.012 .
返回引文位置Google Scholar
百度学术
万方数据
[20]
Chen M , Yoon G ．Posterior corneal aberrations and their compensation effects on anterior corneal aberrations in keratoconic eyes[J]．Invest Ophthalmol Vis Sci， 2008，49(12)∶5645-5652. DOI： 10.1167/iovs.08-1874 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Çevik SG , Kıvanç SA , Akova-Budak B ，et al. Relationship among corneal biomechanics，anterior segment parameters，and geometric corneal parameters[J/OL]．J Ophthalmol， 2016，2016∶8418613[2017－04－06]．https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099453/. DOI： 10.1155/2016/8418613 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
窦瑞，王雁，李华．单纯近视患者Corvis ST测定的角膜形变参数与角膜形态学参数的相关性[J]．中华实验眼科杂志， 2016，34(9)∶829-836. DOI： 10.3760/cma.j.issn.2095-0160.2016.09.012 .
返回引文位置Google Scholar
百度学术
万方数据
Dou R , Wang Y , Li H ．Correlations between the deformation parameters measured by Corvis ST and corneal morphology parameters in myopic patients[J]．Chin J Exp Ophthalmol， 2016，34(9)∶829-836. DOI： 10.3760/cma.j.issn.2095-0160.2016.09.012 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[23]
陈开建，阚秋霞，白继，等．Corvis眼压测量及其与角膜生物力学特性的相关性[J]．中华实验眼科杂志， 2016，34(2)∶166-169. DOI： 10.3760/cma.j.issn.2095-0160.2016.02.015 .
返回引文位置Google Scholar
百度学术
万方数据
Chen KJ , Kan QX , Bai J ，et al. Corvis measurement of intraocular pressure and its relationship with corneal biomechanical properties[J]．Chin J Exp Ophthalmol， 2016，34(2)∶166-169. DOI： 10.3760/cma.j.issn.2095-0160.2016.02.015 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[24]
Wang J , Li Y , Jin Y ，et al. Corneal biomechanical properties in myopic eyes measured by a dynamic scheimpflug analyzer[J/OL]．J Ophthalmol， 2015，2015∶161869[2017－03－13]．https://www.hindawi.com/journals/joph/2015/161869/. DOI： 10.1155/2015/161869 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
祖培培，王雁，王璐，等．近视眼角膜高阶像差特征及与全眼高阶像差的关系[J]．中华眼视光学与视觉科学杂志， 2013，15(3)∶137-141. DOI： 10.3760/cma.j.issn.1674-845X.2013.03.003 .
返回引文位置Google Scholar
百度学术
万方数据
Zu PP , Wang Y , Wang L ，et al. The characteristics of corneal higher-order aberrations in myopia and the correlation between corneal and ocular higher-order aberrations[J]．Chin J Optom Ophthalmol Vis Sci， 2013，15(3)∶137-141. DOI： 10.3760/cma.j.issn.1674-845X.2013.03.003 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
备注信息
A
王雁，Email： mocdef.aabnis.piv3417naygnaw
B
国家自然科学基金项目 (81670884、81470658)
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