高级检索
中华结核和呼吸杂志
期刊首页
过刊列表
高级检索
稿件发表
• 综述 •
ENGLISH ABSTRACT
微小RNA在脓毒症中的研究进展
王江
赵世峰
谢菲
杨晓丹
闫鹏
解立新
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1001-0939.2018.09.016
The research progress on the function and clinical value of micro RNA in sepsis
Wang Jiang
Zhao Shifeng
Xie Fei
Authors Info & Affiliations
Wang Jiang
Zhao Shifeng
Xie Fei
·
DOI： 10.3760/cma.j.issn.1001-0939.2018.09.016
551
65
0
0
0
0
PDF下载
APP内阅读
摘要

脓毒症是临床上常见的全身性重症感染性疾病，可并发脓毒症休克、急性肾损伤(acute kidney injury，AKI)、急性肺损伤(acute lung injury，ALI)及多器官功能衰竭(multiple organ dysfunction syndrome，MODS)等严重并发症。全球每年约有400万患者因脓毒症去世，其发病率呈逐年上升趋势 [ 1 ] 。炎症反应、免疫应答、凝血功能障碍等多种因素构成了脓毒症复杂的调控网络，其致病机制至今尚未完全阐明 [ 2 , 3 ] 。

引用本文

王江,赵世峰,谢菲,等. 微小RNA在脓毒症中的研究进展[J]. 中华结核和呼吸杂志,2018,41(9)：734-736.

DOI:10.3760/cma.j.issn.1001-0939.2018.09.016

PERMISSIONS

Request permissions for this article from CCC.

评价本文
*以上评分为匿名评价

版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

脓毒症是临床上常见的全身性重症感染性疾病，可并发脓毒症休克、急性肾损伤(acute kidney injury，AKI)、急性肺损伤(acute lung injury，ALI)及多器官功能衰竭(multiple organ dysfunction syndrome，MODS)等严重并发症。全球每年约有400万患者因脓毒症去世，其发病率呈逐年上升趋势 [ 1 ]。炎症反应、免疫应答、凝血功能障碍等多种因素构成了脓毒症复杂的调控网络，其致病机制至今尚未完全阐明 [ 2 , 3 ]。
微小RNA(microRNA，miRNA)是一类由内源性基因编码的长度为21～23个核苷酸的非编码单链RNA分子，由具有发夹结构的70～100个核苷酸大小的pre-miRNA通过转运蛋白exportion-5进入细胞质，且被核酸酶Dicer剪切加工而成，不直接参与编码蛋白质 [ 4 ]。其功能主要是直接结合到特定靶基因的3′-非编码区(untranslated region，UTR)来影响功能基因的表达，从而对机体各类病理生理过程发挥重要调控作用 [ 5 ]。随着对脓毒症研究的逐渐深入，人们发现miRNA发挥着重要的调控功能，同时特异miRNA作为脓毒症患者的临床诊断及预后的无创生物学指标也具有一定的应用价值 [ 6 ]。此外，尚有学者尝试使用靶向miRNA来治疗脓毒症，并已显示出潜在的临床价值 [ 7 ]。本文现就脓毒症中miRNA的调控机制及临床应用价值综述如下。
试读结束，您可以通过登录机构账户或个人账户后获取全文阅读权限。
参考文献
[1]
Tillmann B , Wunsch H . Epidemiology and Outcomes[J]. Crit Care Clin, 2018,34(1):15-27. DOI: 10.1016/j.ccc.2017.08.001 .
返回引文位置Google Scholar
百度学术
万方数据
[2]
Pool R , Gomez H , Kellum JA . Mechanisms of Organ Dysfunction in Sepsis[J]. Crit Care Clin, 2018,34(1):63-80. DOI: 10.1016/j.ccc.2017.08.003 .
返回引文位置Google Scholar
百度学术
万方数据
[3]
肖坤，苏龙翔，解立新. 蛋白质组学在脓毒症研究中的最新进展[J]．中华结核和呼吸杂志， 2013，36(8):606-608. DOI: 10.3760/cma.j.issn.1001-0939.2013.08.013 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Liao W , Dong J , Peh HY ,et al. Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases[J]. Molecules, 2017,22(1)．DOI: 10.3390/molecules22010139 .
返回引文位置Google Scholar
百度学术
万方数据
[5]
Kalogianni DP , Kalligosfyri PM , Kyriakou IK ,et al. Advances in microRNA analysis[J]. Anal Bioanal Chem, 2018,410(3):695-713. DOI: 10.1007/s00216-017-0632-z .
返回引文位置Google Scholar
百度学术
万方数据
[6]
Zhang TN , Li D , Xia J ,et al. Non-coding RNA: a potential biomarker and therapeutic target for sepsis[J]. Oncotarget, 2017,8(53):91765-91778. DOI: 10.18632/oncotarget.21766 .
返回引文位置Google Scholar
百度学术
万方数据
[7]
Wu J , Wang Y , Li L . Functional significance of exosomes applied in sepsis: A novel approach to therapy[J]. Biochim Biophys Acta, 2017,1863(1):292-297. DOI: 10.1016/j.bbadis.2016.10.024 .
返回引文位置Google Scholar
百度学术
万方数据
[8]
Reithmair M , Buschmann D , Märte M ,et al. Cellular and extracellular miRNAs are blood-compartment-specific diagnostic targets in sepsis[J]. J Cell Mol Med, 2017,21(10):2403-2411. DOI: 10.1111/jcmm.13162 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Vasilescu C , Dragomir M , Tanase M ,et al. Circulating miRNAs in sepsis-A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis[J]. PLoS One, 2017,12(8):e0183334. DOI: 10.1371/journal.pone.0183334 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Gao N , Dong L . MicroRNA-146 regulates the inflammatory cytokines expression in vascular endothelial cells during sepsis[J]. Pharmazie, 2017,72(11):700-704. DOI: 10.1691/ph.2017.7600 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Xu L , Zhang W , Sun R ,et al. IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes[J]. Exp Ther Med, 2017,14(1):797-804. DOI: 10.3892/etm.2017.4553 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
Ge QM , Huang CM , Zhu XY ,et al. Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways[J]. PLoS One, 2017,12(3):e0173292. DOI: 10.1371/journal.pone.0173292 .
返回引文位置Google Scholar
百度学术
万方数据
[13]
Wang S , Zhang Z , Wang J ,et al. MiR-107 induces TNF-α secretion in endothelial cells causing tubular cell injury in patients with septic acute kidney injury[J]．Biochem Biophys Res Commun, 2017,483(1):45-51. DOI: 10.1016/j.bbrc.2017.01.013 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Wang S , Wang J , Zhang Z ,et al. Decreased miR-128 and increased miR-21 synergistically cause podocyte injury in sepsis[J]. J Nephrol, 2017,30(4):543-550. DOI: 10.1007/s40620-017-0405-y .
返回引文位置Google Scholar
百度学术
万方数据
[15]
Liu J , Li G , Chen C ,et al. MiR-6835 promoted LPS-induced inflammation of HUVECs associated with the interaction between TLR-4 and AdipoR1 in lipid rafts[J]. PLoS One, 2017,12(11):e0188604. DOI: 10.1371/journal.pone.0188604 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Correia CN , Nalpas NC , McLoughlin KE ,et al. Circulating microRNAs as Potential Biomarkers of Infectious Disease[J]. Front Immunol, 2017,8:118. DOI: 10.3389/fimmu.2017.00118 .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Benz F , Roy S , Trautwein C ,et al. Circulating MicroRNAs as Biomarkers for Sepsis[J]. Int J Mol Sci, 2016,17(1)．DOI: 10.3390/ijms17010078 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Liu S , Liu C , Wang Z ,et al. microRNA-23a-5p acts as a potential biomarker for sepsis-induced acute respiratory distress syndrome in early stage[J]. Cell Mol Biol (Noisy-le-grand), 2016,62(2):31-37.
返回引文位置Google Scholar
百度学术
万方数据
[19]
Caserta S , Kern F , Cohen J ,et al. Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS)[J]. Sci Rep, 2016,6:28006. DOI: 10.1038/srep28006 .
返回引文位置Google Scholar
百度学术
万方数据
[20]
Han Y , Dai QC , Shen HL ,et al. Diagnostic value of elevated serum miRNA-143 levels in sepsis[J]. J Int Med Res, 2016,44(4):875-881. DOI: 10.1177/0300060516645003 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Han Y , Li Y , Jiang Y . Th e Prognostic Value of Plasma MicroRNA-155 and MicroRNA-146a Level in Severe Sepsis and Sepsis-Induced Acute Lung Injury Patients [J]. Clin Lab, 2016,62(12):2355-2360.
返回引文位置Google Scholar
百度学术
万方数据
[22]
Goodwin AJ , Guo C , Cook JA ,et al. Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study[J]. Crit Care, 2015,19:440. DOI: 10.1186/s13054-015-1162-8 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
van der Heide V , Möhnle P , Rink J ,et al. Down-regulation of MicroRNA-31 in CD4＋ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing[J]. Anesthesiology, 2016,124(4):908-922. DOI: 10.1097/ALN.0000000000001031 .
返回引文位置Google Scholar
百度学术
万方数据
[24]
Huang H , Xu R , Lin F ,et al. High circulating CD39(＋) regulatory T cells predict poor survival for sepsis patients[J]. Int J Infect Dis, 2015,30:57-63. DOI: 10.1016/j.ijid.2014.11.006 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Vincent JL , Grimaldi D . Novel Interventions: What′s New and the Future[J]. Crit Care Clin, 2018,34(1):161-173. DOI: 10.1016/j.ccc.2017.08.012 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Chen Y , Peng H , Zhou S ,et al. ADAR1 is targeted by miR-143 to regulate IL-1β-induced endothelial activation through the NFκB pathway[J]．Int J Biochem Cell Biol, 2017,89:25-33. DOI: 10.1016/j.biocel.2017.05.021 .
返回引文位置Google Scholar
百度学术
万方数据
[27]
Kalantari P , Harandi OF , Agarwal S ,et al. miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)[J]. J Biol Chem, 2017,292(14):5634-5644. DOI： 10.1074/jbc.M116.749325 .
返回引文位置Google Scholar
百度学术
万方数据
[28]
Sheng B , Zhao L , Zang X ,et al. miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling [J]. Biomed Pharmacother, 2017,86:254-261. DOI: 10.1016/j.biopha.2016.11.147 .
返回引文位置Google Scholar
百度学术
万方数据
[29]
Zheng D , Yu Y , Li M ,et al. Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis[J]. J Infect Dis, 2016,213(10):1661-1670. DOI: 10.1093/infdis/jiv760 .
返回引文位置Google Scholar
百度学术
万方数据
[30]
Liu Y , Guan H , Zhang JL ,et al. Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1[J]. Am J Physiol Cell Physiol, 2018,314(4):C449-449C455. DOI: 10.1152/ajpcell.00173.2017 .
返回引文位置Google Scholar
百度学术
万方数据
[31]
Yang S , Wang Y , Gao H ,et al. MicroRNA-30a-3p overexpression improves sepsis-induced cell apoptosis in vitro and in vivo via the PTEN/PI3K/AKT signaling pathway[J]. Exp Ther Med, 2018,15(2):2081-2087. DOI: 10.3892/etm.2017.5644 .
返回引文位置Google Scholar
百度学术
万方数据
[32]
Zhou Y , Song Y , Shaikh Z ,et al. MicroRNA-155 attenuates late sepsis-induced cardiac dysfunction through JNK and β-arrestin 2[J]．Oncotarget, 2017,8(29):47317-47329. DOI: 10.18632/oncotarget.17636 .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
解立新，Email： mocdef.6ab21103xleix
B
国家自然科学基金 (81670005，81170008)
评论 （0条）
注册
登录
时间排序
暂无评论，发表第一条评论抢沙发
最新推荐
更多
血清淀粉样蛋白A、白介素6、肿瘤坏死因子α及微小RNA在脓毒症并发急性肾损伤患儿中的表达及预后评估价值研究
王林娜 等
中国全科医学 2025,28(03)
微小RNA工程化外泌体在糖尿病创面中的作用研究进展
简喜超 等
中华烧伤与创面修复杂志 2024,40(02)
微小RNA在脓毒症所致急性肾损伤中的应用
董虹杏 等
中国综合临床 2023,39(05)
微小RNA在脓毒症性急性肾损伤中的研究进展
彭文静 等
中华危重病急救医学 2022,34(05)
MedAI助手（体验版）
文档即答
智问智答
机器翻译
回答内容由人工智能生成，我社无法保证其准确性和完整性，该生成内容不代表我们的态度或观点，仅供参考。
生成快照
文献快照

你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。

0/2000

《中华医学会杂志社用户协议》 | 《隐私政策》

《SparkDesk 用户协议》 | 《SparkDesk 隐私政策》

网信算备340104764864601230055号 | 网信算备340104726288401230013号

技术支持：

历史对话
本文全部
还没有聊天记录
设置
模式
纯净模式沉浸模式
字号
小中大