高级检索
中华骨科杂志
期刊首页
过刊列表
高级检索
稿件发表
• 综述 •
ENGLISH ABSTRACT
髋关节置换术后金属离子相关并发症的研究进展
王一鸣
徐卫东
作者及单位信息
·
DOI： 10.3760/cma.j.issn.0253-2352.2018.23.008
Metal ions related complications after hip arthroplasty
Wang Yiming
Xu Weidong
Authors Info & Affiliations
Wang Yiming
Department of Joint Surgery and Sports Medicine, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Xu Weidong
Department of Joint Surgery and Sports Medicine, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China
·
DOI： 10.3760/cma.j.issn.0253-2352.2018.23.008
1181
74
0
0
2
0
PDF下载
APP内阅读
摘要

金属-金属髋关节置换术后体内金属离子蓄积及相关并发症的问题一直受到关节外科医生的关注；人工关节假体头颈交界处锥部腐蚀导致的金属离子问题，也是人工关节领域的研究热点。金属离子相关并发症的影响是否如预估的那样严重，其具体表现形式、作用机制等问题尚存在争议，对金属离子的临床检测方法及标准也没有统一共识。通过文献回顾对上述问题进行归纳总结，以期对金属离子相关并发症的问题有更深入的认识。金属离子相关并发症包括局部性和系统性，前者主要是局部组织不良反应，尤以假瘤为代表，但假瘤发生率及影响因素尚不明确；后者包括致癌性、致畸性等，但目前还没有明确的证据。钴铬等金属毒性的分子机制涉及诸多信号转导通路，其组织病理学机制包括巨噬细胞介导的非特异性免疫和淋巴细胞介导的特异性免疫，前者主要与磨损剂量有关、后者与金属敏感性相关，个体差异较大。金属离子浓度检测的方法目前较常用的是电感耦合等离子质谱耦合法。金属离子浓度临界值的确定对诊断有重要的指导意义，过去常用的标准是英国学者提出的7 μg/L，现在也有许多不同的意见。总而言之，目前认为髋关节置换术后金属离子相关并发症是由于钴铬金属离子激活非特异性免疫与特异性免疫共同作用的结果，异常激活的诸多信号通路导致了局部的软组织反应，而全身性并发症并没有明确的证据；对于金属离子浓度检测也没有统一标准，实际临床工作中不建议对此指标过于推荐，应综合评估患者情况。

ABSTRACT

The problems of metal ions accumulation and related complications after metal-on-metal hip arthroplasty have been concerned by joint surgeons. Furthermore, metal ions released resulting from taper fretting and corrosion at the head-neck junction of prosthesis are also research hotspot in the field of arthroplasty. Whether the complications associated with metal ions are as serious as expected, its specific manifestations, mechanisms and other issues are still controversial. There is no consensus on the clinical detection methods and standards of metal ions. The present study reviews the literatures and summarizes the above issues, in order to have a deeper understanding of these issues. As far as the form of complication is concerned, there are local and systemic reactions. The former is mainly an adverse reaction of local tissue, especially pseudotumor. However, the incidence of pseudotumor and its risk factors are controversial. There is no clear evidence of systemic complications such as carcinogenicity and teratogenicity. The molecular mechanism of cobalt-chromium toxicity involves many signal transduction pathways, and its histopathological mechanism includes macrophage-mediated nonspecific immunity and lymphocyte-mediated specific immunity. The former is mainly related to the wear dose, while the latter is related to metal sensitivity with great individual difference. The method of metal ion concentration determination is still controversial. The inductively coupled plasma mass spectrometry (ICP-MS) is widely used at present, and the determination of metal ion concentration critical value has important guiding significance for clinical practice. Britain's 7 μg/L proposal was once discussed as a standard, while there are many different views currently. In summary, it is thought that the complication of metal ion after hip arthroplasty is the result of cobalt chromium metal ion activating nonspecific immunity and specific immunity. Abnormal activation of many signaling pathways leads to local soft tissue reactions, while systemic complications do not have clear evidence. Furthermore, there is no uniform standard for the detection of metal ion concentration. This index is not recommended in clinical practice. We should have a comprehensive assessment of the patient's situation.

Xu Weidong, E-mail: mocdef.6ab21iahgnahsdwux
Copyright by Chinese Medical Association
No content published by the journals of Chinese Medical Association may be reproduced or abridged without authorization. Please do not use or copy the layout and design of the journals without permission.
All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.
引用本文

王一鸣,徐卫东. 髋关节置换术后金属离子相关并发症的研究进展[J]. 中华骨科杂志,2018,38(23)：1469-1476.

DOI:10.3760/cma.j.issn.0253-2352.2018.23.008

PERMISSIONS

Request permissions for this article from CCC.

评价本文
*以上评分为匿名评价

版权归中华医学会所有。

未经授权，不得转载、摘编本刊文章，不得使用本刊的版式设计。

除非特别声明，本刊刊出的所有文章不代表中华医学会和本刊编委会的观点。

20多年前，由钴铬合金制备的新一代金属-金属关节假体问世，成功地避免了金属-聚乙烯假体聚乙烯磨损颗粒导致的骨溶解、松动等并发症，使金属-金属关节摩擦副又重新得到广泛应用 [ 1 ]。新一代金属-金属全髋关节置换（total hip arthroplasty，THA）的容积磨损更小，消除了聚乙烯颗粒导致的骨溶解，大直径的股骨头可增加假体稳定性 [ 2 ]；金属-金属髋关节表面置换（hip resurfacing arthroplasty，HRA）不破坏近端股骨骨量，可保留本体感觉，有更接近于生理状态的应力传导，稳定性好、脱位率低 [ 3 ]。基于这些优点，金属-金属假体的临床应用迅速普及，迄今全球范围内有超过100万的患者接受了金属-金属髋关节置换手术 [ 4 ]，国内外的研究均获得了良好的早期结果 [ 5 , 6 , 7 ]。但随后对金属-金属假体不良事件的报道越来越多，诸如血金属离子浓度升高、局部软组织反应等，使金属摩擦副的安全性受到质疑。尤其近年来随着髋关节翻修病例的增加，金属相关并发症的问题日益凸显。除摩擦副的接触界面外，股骨头假体与股骨柄连接处的锥部腐蚀、组配式假体组件之间的微动也是金属离子的重要来源 [ 8 , 9 ]，且不局限于金属-金属假体，这也是近年来的研究热点。但是目前临床上对金属离子引起的并发症，无论是局部的还是全身性的还存在争议，金属离子介导的并发症的发生机制仍不明确，对金属离子的临床检测方法及标准也没有统一意见。
本文以"髋关节置换"和"金属离子"，以"hip arthroplasty"或"hip replacement"和"metal ions"为检索词，分别在CNKI、PubMed、Embase、Web of Science数据库进行文献检索。文献的纳入标准为：1文献类型包括期刊论文、综述或编者按；2文献内容与髋关节置换金属离子问题密切相关；3相同领域的优先选择近期发表或发表在权威杂志上的文献。排除标准：1会议记录、通信、评论等类型的文献，非英文的外文文献；2重复文献及无法获得全文的文献；3质量不高、证据等级低、病例数量少的研究文献。共检索出文献1 318篇，最终纳入93篇（ 图1 ）。
文献检索流程图，最终纳入文献93篇
试读结束，您可以通过登录机构账户或个人账户后获取全文阅读权限。
参考文献
[1]
徐卫东，李甲. 髋关节表面置换的历史发展及经验[J]. 中国矫形外科杂志, 2007,15(17):1322-1324. DOI: 10.3969/j.issn.1005-8478.2007.17.013 .
返回引文位置Google Scholar
百度学术
万方数据
Xu WD , Li J . Historical development and experience of Hip Resurfacing Arthroplasty[J]. Orthop J Chin, 2007,15(17):1322-1324. DOI: 10.3969/j.issn.1005-8478.2007.17.013 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[2]
MacDonald SJ , McCalden RW , Chess DG ,et al. Metal-on-metal versus polyethylene in hip arthroplasty: a randomized clinical trial[J]. Clin Orthop Relat Res, 2003(406):282-296. DOI: 10.1097/01.blo.0000043066.62337.9d .
返回引文位置Google Scholar
百度学术
万方数据
[3]
Daniel J , Pynsent PB , McMinn DJ . Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis[J]. J Bone Joint Surg Br, 2004,86(2):177-184. DOI: 10.1302/0301-620X.86B2.14600 .
返回引文位置Google Scholar
百度学术
万方数据
[4]
Bozic KJ , Kurtz S , Lau E ,et al. The Epidemiology of Bearing Surface Usage in Total Hip Arthroplasty in the United States[J]. J Bone Joint Surg Am, 2009,91(7):1614-1620. DOI: 10.2106/JBJS.H.01220 .
返回引文位置Google Scholar
百度学术
万方数据
[5]
曾羿，沈彬，黄强,等. 大直径股骨头金属对金属全髋关节置换术的近期临床疗效[J]. 中华骨科杂志, 2011,31(5):469-474. DOI: 10.3760/cma.j.issn.0253-2352.2011.05.010 .
返回引文位置Google Scholar
百度学术
万方数据
Zeng Y , Shen B , Huang Q ,et al. Short-term effects of total hip arthroplasty using metal-on-metal prosthesis with large diameter femoral head[J]. Chin J Orthop, 2011,31(5):469-474. DOI: 10.3760/cma.j.issn.0253-2352.2011.05.010 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[6]
勘武生，徐敏超，陈明,等. 大直径金属对金属假体与传统假体全髋关节置换术的早期疗效比较[J]. 中华骨科杂志, 2010,30(2):170-174. DOI: 10.3760/cma.j.issn.0253-2352.2010.02.008 .
返回引文位置Google Scholar
百度学术
万方数据
Kan WS , Xu MC , Chen M ,et al. Comparative study on early clinical effect between large-diameter metal-on-metal prosthesis and traitional prosthesis in total hip replacement[J]. Chin J Orthop, 2010,30(2):170-174. DOI: 10.3760/cma.j.issn.0253-2352.2010.02.008 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[7]
何志勇，狄正林，曾智敏,等. 金属对金属全髋关节表面置换术的近期疗效[J]. 中华骨科杂志, 2012,32(6):533-538. DOI: 10.3760/cma.j.issn.0253-2352.2012.06.004 .
返回引文位置Google Scholar
百度学术
万方数据
He ZY , Di ZL , Zeng ZM ,et al. Preliminary results after metal-on-metal hip resurfacing arthroplasty[J]. Chin J Orthop, 2012,32(6):533-538. DOI: 10.3760/cma.j.issn.0253-2352.2012.06.004 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[8]
Kocagoz SB , Underwood RJ , MacDonald DW ,et al. Ceramic Heads Decrease Metal Release Caused by Head-taper Fretting and Corrosion[J]. Clin Orthop Relat Res, 2016,474(4):985-994. DOI: 10.1007/s11999-015-4683-1 .
返回引文位置Google Scholar
百度学术
万方数据
[9]
Mistry JB , Chughtai M , Elmallah RK ,et al. Trunnionosis in total hip arthroplasty: a review[J]. J Orthop Traumatol, 2016,17(1):1-6. DOI: 10.1007/s10195-016-0391-1 .
返回引文位置Google Scholar
百度学术
万方数据
[10]
Haddad FS , Thakrar RR , Hart AJ ,et al. Metal-on-metal bearings: the evidence so far[J]. J Bone Joint Surg Br, 2011,93(5):572-579. DOI: 10.1302/0301-620X.93B4.26429 .
返回引文位置Google Scholar
百度学术
万方数据
[11]
Liow MHL , Kwon YM . Metal-on-metal total hip arthroplasty: risk factors for pseudotumours and clinical systematic evaluation[J]. Int Orthop, 2017,41(5):885-892. DOI: 10.1007/s00264-016-3305-1 .
返回引文位置Google Scholar
百度学术
万方数据
[12]
Birkett N , El-Daly I , Ibraheim H ,et al. Metallosis following full thickness wear in total hip arthroplasty[J]. J Surg Case Rep, 2015,2015(9). DOI: 10.1093/jscr/rjv122 .
返回引文位置Google Scholar
百度学术
万方数据
[13]
Pelt CE , Erickson J , Clarke I ,et al. Histologic, serologic, and tribologic findings in failed metal-on-metal total hip arthroplasty: AAOS exhibit selection[J]. J Bone Joint Surg Am, 2013,95(21):e163. DOI: 10.2106/JBJS.L.01446 .
返回引文位置Google Scholar
百度学术
万方数据
[14]
Bin Nasser A , Beaulé PE , O'Neill M ,et al. Incidence of Groin Pain After Metal-on-Metal Hip Resurfacing[J]. Clin Orthop Relat Res, 2010,468(2):392-399. DOI: 10.1007/s11999-009-1133-y .
返回引文位置Google Scholar
百度学术
万方数据
[15]
van der Weegen W , Brakel K , Horn RJ ,et al. Asymptomatic pseudotumours after metal-on-metal hip resurfacing show little change within one year[J]. Bone Joint J, 2013,95-B(12):1626-1631. DOI: 10.1302/0301-620X.95B12.32248 .
返回引文位置Google Scholar
百度学术
万方数据
[16]
Daniel J , Holland J , Quigley L ,et al. Pseudotumors associated with total hip arthroplasty[J]. J Bone Joint Surg Am, 2012,94(1):86-93. DOI: 10.2106/JBJS.J.01612 .
返回引文位置Google Scholar
百度学术
万方数据
[17]
Canadian Hip Resurfacing Study Group. A survey on the prevalence of pseudotumors with metal-on-metal hip resurfacing in Canadian academic centers[J]. J Bone Joint Surg Am, 2011,93Suppl 2:S118-121. DOI: 10.2106/JBJS.J.01848 .
返回引文位置Google Scholar
百度学术
万方数据
[18]
Sutphen SA , MacLaughlin LH , Madsen AA ,et al. Prevalence of Pseudotumor in Patients After Metal-On-Metal Hip Arthroplasty Evaluated with Metal Ion Analysis and MARS-MRI[J]. J Arthroplasty, 2016,31(1):260-263. DOI: 10.1016/j.arth.2015.07.011 .
返回引文位置Google Scholar
百度学术
万方数据
[19]
Matthies AK , Skinner JA , Osmani H ,et al. Pseudotumors Are Common in Well-positioned Low-wearing Metal-on-Metal Hips[J]. Clin Orthop Relat Res, 2012,470(7):1895-1906. DOI: 10.1007/s11999-011-2201-7 .
返回引文位置Google Scholar
百度学术
万方数据
[20]
Caicedo MS , Solver E , Coleman L ,et al. Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males: Implications of Sex-Based Bioreactivity Differences[J]. J Bone Joint Surg Am, 2017,99(8):621-628. DOI: 10.2106/JBJS.16.00720 .
返回引文位置Google Scholar
百度学术
万方数据
[21]
Murray DW , Grammatopoulos G , Pandit H ,et al. The ten-year survival of the Birmingham hip resurfacing: an independent series[J]. J Bone Joint Surg Br, 2012,94(94):1180-1186. DOI: 10.1302/0301-620X.94B9.29462 .
返回引文位置Google Scholar
百度学术
万方数据
[22]
Bayley N , Khan H , Grosso P ,et al. What are the predictors and prevalence of pseudotumor and elevated metal ions after large-diameter metal-on-metal THA?[J]. Clin Orthop Relat Res, 2015,473(2):477-484. DOI: 10.1007/s11999-014-3824-2 .
返回引文位置Google Scholar
百度学术
万方数据
[23]
Bisschop R , Boomsma MF , Van Raay JJ ,et al. High prevalence of pseudotumors in patients with a Birmingham Hip Resurfacing prosthesis: a prospective cohort study of one hundred and twenty-nine patients[J]. J Bone Joint Surg Am, 2013,95(17):1554-1560. DOI: 10.2106/JBJS.L.00716 .
返回引文位置Google Scholar
百度学术
万方数据
[24]
Visuri T , Pukkala E , Paavolainen P ,et al. Cancer risk after metal on metal and polyethylene on metal total hip arthroplasty[J]. Clin Orthop Relat Res, 1996,329(329Suppl):S280-289. DOI: 10.1097/00003086-199608001-00025 .
返回引文位置Google Scholar
百度学术
万方数据
[25]
Visuri T , Pulkkinen P , Paavolainen P ,et al. Cancer risk is not increased after conventional hip arthroplasty[J]. Acta Orthop, 2010,81(1):77-81. DOI: 10.3109/17453671003667150 .
返回引文位置Google Scholar
百度学术
万方数据
[26]
Onega T , Baron J , MacKenzie T . Cancer after Total Joint Arthroplasty: A Meta-analysis[J]. Cancer Epidemiol Biomarkers Prev, 2006,15(8):1532-1537. DOI: 10.1158/1055-9965.EPI-06-0127 .
返回引文位置Google Scholar
百度学术
万方数据
[27]
Mäkelä KT , Visuri T , Pulkkinen P ,et al. Cancer incidence and cause-specific mortality in patients with metal-on-metal hip replacements in Finland[J]. Acta Orthop, 2014,85(1):32-38. DOI: 10.3109/17453674.2013.878830 .
返回引文位置Google Scholar
百度学术
万方数据
[28]
Onega T , Baron J , MacKenzie T ,et al. Cancer after Total Joint Arthroplasty: A Meta-analysis[J]. Cancer Epidemiol Biomarkers Prev, 2006,15(8):1532-1537. DOI: 10.1158/1055-9965.EPI-06-0127 .
返回引文位置Google Scholar
百度学术
万方数据
[29]
曾羿，沈彬，裴福兴. 金属对金属关节摩擦界面相关问题的研究进展[J]. 中华骨科杂志, 2009,29(11):1067-1070. DOI: 10.3760/cma.j.issn.0253-2352.2009.11.016 .
返回引文位置Google Scholar
百度学术
万方数据
Zeng Y , Shen B , Pei FX . Research Progress of Metal-to-Metal Joint friction Interface[J]. Chin J Orthop, 2009,29(11):1067-1070. DOI: 10.3760/cma.j.issn.0253-2352.2009.11.016 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[30]
Brodner W , Grohs JG , Bancher-Todesca D ,et al. Does the placenta inhibit the passage of chromium and cobalt after metal-on-metal total hip arthroplasty?[J]. J Arthroplasty, 2004,19(8):102-106. DOI: 10.1016/j.arth.2004.09.020 .
返回引文位置Google Scholar
百度学术
万方数据
[31]
Ziaee H , Daniel J , Datta AK ,et al. Transplacental transfer of cobalt and chromium in patients with metal-on-metal hip arthroplasty: a controlled study[J]. J Bone Joint Surg Br, 2007,89(3):301-305. DOI: 10.1302/0301-620X.89B3.18520 .
返回引文位置Google Scholar
百度学术
万方数据
[32]
Cheung AC , Banerjee S , Cherian JJ ,et al. Systemic cobalt toxicity from total hip arthroplasties: review of a rare condition Part 1-history, mechanism, measurements, and pathophysiology[J]. Bone Joint J, 2016,98-B(1):6-13. DOI: 10.1302/0301-620X.98B1.36374 .
返回引文位置Google Scholar
百度学术
万方数据
[33]
Mosier BA , Maynard L , Sotereanos NG ,et al. Progressive Cardiomyopathy in a Patient With Elevated Cobalt Ion Levels and Bilateral Metal-on-Metal Hip Arthroplasties[J]. Am J Orthop (Belle Mead NJ), 2016,45(3):E132-135.
返回引文位置Google Scholar
百度学术
万方数据
[34]
Gilbert CJ , Cheung A , Butany J ,et al. Hip pain and heart failure: the missing link[J]. Can J Cardiol, 2013,29(5):639. e1-2. DOI: 10.1016/j.cjca.2012.10.015 .
返回引文位置Google Scholar
百度学术
万方数据
[35]
Doorn PF , Campbell PA , Worrall J ,et al. Metal wear particle characterization from metal on metal total hip replacements: transmission electron microscopy study of periprosthetic tissues and isolated particles[J]. J Biomed Mater Res, 1998,42(1):103-111. DOI: 10.1002/(SICI)1097-4636(199810)42:1<103::AID-JBM13>3.0.CO;2-M .
返回引文位置Google Scholar
百度学术
万方数据
[36]
Keegan GM , Learmonth ID , Case CP . A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants[J]. Crit Rev Toxicol, 2008,38(8):645-674. DOI: 10.1080/10408440701845534 .
返回引文位置Google Scholar
百度学术
万方数据
[37]
Hart AJ , Quinn PD , Sampson B ,et al. The chemical form of metallic debris in tissues surrounding metal-on-metal hips with unexplained failure[J]. Acta Biomater, 2010,6(11):4439-4446. DOI: 10.1016/j.actbio.2010.06.006 .
返回引文位置Google Scholar
百度学术
万方数据
[38]
Xia Z , Kwon YM , Mehmood S ,et al. Characterization of metal-wear nanoparticles in pseudotumor following metal-on-metal hip resurfacing[J]. Nanomedicine, 2011,7(6):674-681. DOI: 10.1016/j.nano.2011.08.002 .
返回引文位置Google Scholar
百度学术
万方数据
[39]
Haynes DR , Rogers SD , Howie DW ,et al. Drug inhibition of the macrophage response to metal wear particles in vitro[J]. Clin Orthop Relat Res, 1996(323):316-326. DOI: 10.1097/00003086-199602000-00045 .
返回引文位置Google Scholar
百度学术
万方数据
[40]
Xia Z , Triffitt JT . A review on macrophage responses to biomaterials[J]. Biomed Mater, 2006,1(1):R1-9. DOI: 10.1088/1748-6041/1/1/R01 .
返回引文位置Google Scholar
百度学术
万方数据
[41]
Glyn-Jones S , Roques A , Taylor A ,et al. The in vivo linear and volumetric wear of hip resurfacing implants revised for pseudotumor[J]. J Bone Joint Surg Am, 2011,93(23):2180-2188. DOI: 10.2106/JBJS.J.01206 .
返回引文位置Google Scholar
百度学术
万方数据
[42]
Grammatopoulos G , Pandit H , Kamali A ,et al. The correlation of wear with histological features after failed hip resurfacing arthroplasty[J]. J Bone Joint Surg Am, 2013,95(12):e81. DOI: 10.2106/JBJS.L.00775 .
返回引文位置Google Scholar
百度学术
万方数据
[43]
Campbell P , Ebramzadeh E , Nelson S ,et al. Histological features of pseudotumor-like tissues from metal-on-metal hips[J]. Clin Orthop Relat Res, 2010,468(9):2321-2327. DOI: 10.1007/s11999-010-1372-y .
返回引文位置Google Scholar
百度学术
万方数据
[44]
Phillips EA , Klein GR , Cates HE ,et al. Histological characterization of periprosthetic tissue responses for metal-on-metal hip replacement[J]. J Long Term Eff Med Implants, 2014,24(1):13-23. DOI: 10.1615/JLongTermEffMedImplants.2014010275 .
返回引文位置Google Scholar
百度学术
万方数据
[45]
Nawabi DH , Nassif NA , Do HT ,et al. What Causes Unexplained Pain in Patients With Metal-on metal Hip Devices? A Retrieval, Histologic, and Imaging Analysis[J]. Clin Orthop Relat Res, 2014,472(2):543-554. DOI: 10.1007/s11999-013-3199-9 .
返回引文位置Google Scholar
百度学术
万方数据
[46]
Berstock JR , Baker RP , Bannister GC ,et al. Histology of failed metal-on-metal hip arthroplasty; three distinct sub-types[J]. Hip Int, 2014,24(3):243-248. DOI: 10.5301/hipint.5000117 .
返回引文位置Google Scholar
百度学术
万方数据
[47]
Ricciardi BF , Nocon AA , Jerabek SA ,et al. Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases[J]. BMC Clin Pathol, 2016,16(1):3. DOI: 10.1186/s12907-016-0025-9 .
返回引文位置Google Scholar
百度学术
万方数据
[48]
陈哲峰，范卫民，王臻,等. 金属对金属人工全髋关节置换术后早期血清金属离子变化及对免疫功能的影响[J]. 中华骨科杂志, 2013,33(5):501-506. DOI: 10.3760/cma.j.issn.0253-2352.2013.05.011 .
返回引文位置Google Scholar
百度学术
万方数据
Chen ZF , Fan WM , Wang Z ,et al. Early results of serum metal ions change and its impact on host immunity after metal-on-metal total hip arthroplasty[J]. Chin J Orthop, 2013,33(5):501-506. DOI: 10.3760/cma.j.issn.0253-2352.2013.05.011 .
Goto CitationGoogle Scholar
Baidu Scholar
Wanfang Data
[49]
Nyga A , Hart A , Tetley TD . Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages[J]. Nanotoxicology, 2015,9(7):905-917. DOI: 10.3109/17435390.2014.991430 .
返回引文位置Google Scholar
百度学术
万方数据
[50]
Olivieri G , Hess C , Savaskan E ,et al. Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion[J]. J Pineal Res, 2001,31(4):320-325. DOI: 10.1034/j.1600-079X.2001.310406.x .
返回引文位置Google Scholar
百度学术
万方数据
[51]
Papageorgiou I , Brown C , Schins R ,et al. The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro[J]. Biomaterials, 2007,28(19):2946-2958. DOI: 10.1016/j.biomaterials.2007.02.034 .
返回引文位置Google Scholar
百度学术
万方数据
[52]
Caicedo MS , Desai R , McAllister K ,et al. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity[J]. J Orthop Res, 2009,27(7):847-854. DOI: 10.1002/jor.20826 .
返回引文位置Google Scholar
百度学术
万方数据
[53]
Scharf B , Clement CC , Zolla V ,et al. Molecular analysis of chromium and cobalt-related toxicity[J]. Sci Rep, 2014,4(4):5729. DOI: 10.1038/srep05729 .
返回引文位置Google Scholar
百度学术
万方数据
[54]
Zywiel MG , Cherian JJ , Banerjee S ,et al. Systemic cobalt toxicity from total hip arthroplasties: review of a rare condition Part 2. measurement, risk factors, and step-wise approach to treatment[J]. Bone Joint J, 2016,98-B(1):14-20. DOI: 10.1302/0301-620X.98B1.36712 .
返回引文位置Google Scholar
百度学术
万方数据
[55]
Lainiala OS , Moilanen TPS , Hart AJ ,et al. Higher Blood Cobalt and Chromium Levels in Patients With Unilateral Metal-on-Metal Total Hip Arthroplasties Compared to Hip Resurfacings[J]. J Arthroplasty, 2015,31(6):1261-1266. DOI: 10.1016/j.arth.2015.11.045 .
返回引文位置Google Scholar
百度学术
万方数据
[56]
Simoes TA , Bryant MG , Brown AP ,et al. Evidence for the dissolution of molybdenum during tribocorrosion of CoCrMo hip implants in the presence of serum protein[J]. Acta Biomater, 2016,45:410-418. DOI: 10.1016/j.actbio.2016.08.051 .
返回引文位置Google Scholar
百度学术
万方数据
[57]
Savarino L , Fotia C , Roncuzzi L ,et al. Does chronic raise of metal ion levels induce oxidative DNA damage and hypoxia-like response in patients with metal-on-metal hip resurfacing?[J]. J Biomed Mater Res B Appl Biomater, 2017,105(2):460-466. DOI: 10.1002/jbm.b.33555 .
返回引文位置Google Scholar
百度学术
万方数据
[58]
Barry J , Lavigne M , Vendittoli PA . Evaluation of the method for analyzing chromium, cobalt and titanium ion levels in the blood following hip replacement with a metal-on-metal prosthesis[J]. J Anal Toxicol, 2013,37(2):90-96. DOI: 10.1093/jat/bks090 .
返回引文位置Google Scholar
百度学术
万方数据
[59]
Rahmé M , Lavigne M , Barry J ,et al. Whole blood metal ion measurement reproducibility between different laboratories[J]. J Arthroplasty, 2014,29(11):2214-2218. DOI: 10.1016/j.arth.2014.07.018 .
返回引文位置Google Scholar
百度学术
万方数据
[60]
MacDonald SJ , Brodner W , Jacobs JJ . A consensus paper on metal ions in metal-on-metal hip arthroplasties[J]. J Arthroplasty, 2004,19(8Suppl 3):S12-16. DOI: 10.1016/j.arth.2004.09.009 .
返回引文位置Google Scholar
百度学术
万方数据
[61]
Smolders JM , Bisseling P , Hol A ,et al. Metal ion interpretation in resurfacing versus conventional hip arthroplasty and in whole blood versus serum. How should we interpret metal ion data[J]. Hip Int, 2011,21(5):587-595. DOI: 10.5301/HIP.2011.8643 .
返回引文位置Google Scholar
百度学术
万方数据
[62]
Daniel J , Ziaee H , Pynsent PB ,et al. The validity of serum levels as a surrogate measure of systemic exposure to metal ions in hip replacement[J]. J Bone Joint Surg Br, 2007,89(6):736-741. DOI: 10.1302/0301-620X.89B6.18141 .
返回引文位置Google Scholar
百度学术
万方数据
[63]
Engh CA , MacDonald SJ , Sritulanondha S ,et al. Metal ion levels after metal-on-metal total hip arthroplasty: a five-year, prospective randomized trial[J]. J Bone Joint Surg Am, 2014,96(6):448-455. DOI: 10.2106/JBJS.M.00164 .
返回引文位置Google Scholar
百度学术
万方数据
[64]
Vendittoli PA , Mottard S , Roy AG ,et al. Chromium and cobalt ion release following the Durom high carbon content, forged metal-on-metal surface replacement of the hip[J]. J Bone Joint Surg Br, 2007,89(4):441-448. DOI: 10.1302/0301-620X.89B4.18054 .
返回引文位置Google Scholar
百度学术
万方数据
[65]
Williams DH , Greidanus NV , Masri BA ,et al. Prevalence of pseudotumor in asymptomatic patients after metal-on-metal hip arthroplasty[J]. J Bone Joint Surg Am, 2011,93(23):2164-2171. DOI: 10.2106/JBJS.J.01884 .
返回引文位置Google Scholar
百度学术
万方数据
[66]
Barlow BT , Ortiz PA , Boles JW ,et al. What Are Normal Metal Ion Levels After Total Hip Arthroplasty? A Serologic Analysis of Four Bearing Surfaces[J]. J Arthroplasty, 2017,32(5):1535-1542. DOI: 10.1016/j.arth.2016.11.024 .
返回引文位置Google Scholar
百度学术
万方数据
[67]
Cooper HJ , Della Valle CJ , Berger RA ,et al. Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty[J]. J Bone Joint Surg Am, 2012,94(18):1655-1661. DOI: 10.2106/JBJS.K.01352 .
返回引文位置Google Scholar
百度学术
万方数据
[68]
Lardanchet JF , Taviaux J , Arnalsteen D ,et al. One-year prospective comparative study of three large-diameter metal-on-metal total hip prostheses: serum metal ion levels and clinical outcomes[J]. Orthop Traumatol Surg Res, 2012,98(3):265-274. DOI: 10.1016/j.otsr.2011.11.009 .
返回引文位置Google Scholar
百度学术
万方数据
[69]
Hart AJ , Sabah SA , Sampson B ,et al. Surveillance of Patients with Metal-on-Metal Hip Resurfacing and Total Hip Prostheses: A Prospective Cohort Study to Investigate the Relationship Between Blood Metal Ion Levels and Implant Failure[J]. J Bone Joint Surg Am, 2014,96(13):1091-1099. DOI: 10.2106/JBJS.M.00957 .
返回引文位置Google Scholar
百度学术
万方数据
[70]
Hart AJ , Skinner JA , Winship P ,et al. Circulating levels of cobalt and chromium from metal-on-metal hip replacement are associated with CD8+ T-cell lymphopenia[J]. J Bone Joint Surg Br, 2009,91(6):835-842. DOI: 10.1302/0301-620X.91B6.21844 .
返回引文位置Google Scholar
百度学术
万方数据
[71]
Matharu GS , Berryman F , Brash L ,et al. Can blood metal ion levels be used to identify patients with bilateral Birmingham Hip Resurfacings who are at risk of adverse reactions to metal debris?[J]. Bone Joint J, 2016,98-B(11):1455-1462. DOI: 10.1302/0301-620X.98B11.38042 .
返回引文位置Google Scholar
百度学术
万方数据
[72]
Matharu GS , Berryman F , Brash L ,et al. The Effectiveness of Blood Metal Ions in Identifying Patients with Unilateral Birmingham Hip Resurfacing and Corail-Pinnacle Metal-on-Metal Hip Implants at Risk of Adverse Reactions to Metal Debris[J]. J Bone Joint Surg Am, 2016,98(8):617-626. DOI: 10.2106/JBJS.15.00340 .
返回引文位置Google Scholar
百度学术
万方数据
[73]
Carlson BC , Bryan AJ , Carrillo-Villamizar NT ,et al. The Utility of Metal Ion Trends in Predicting Revision in Metal-on-Metal Total Hip Arthroplasty[J]. J Arthroplasty, 2017,32(9S):S214-219. DOI: 10.1016/j.arth.2017.02.031 .
返回引文位置Google Scholar
百度学术
万方数据
[74]
Kiran M , Armstrong C , Shivarathre D ,et al. Blood Metal Ion Levels Have Limited Utility in the Surveillance of Asymptomatic Large-Head Metal-on-Metal Total Hip Arthroplasties[J]. J Arthroplasty, 2017,32(12):3685-3688. DOI: 10.1016/j.arth.2017.07.015 .
返回引文位置Google Scholar
百度学术
万方数据
备注信息
A
徐卫东，E-mail: mocdef.6ab21iahgnahsdwux
评论 （0条）
注册
登录
时间排序
暂无评论，发表第一条评论抢沙发
最新推荐
更多
《新生儿脐静脉置管相关并发症防控指南》解读
郑旭 等
中华新生儿科杂志 2022,37(01)
新生儿脐静脉置管相关并发症防控指南
中华医学会儿科学分会新生儿学组 等
中华新生儿科杂志 2021,36(02)
金属离子在阿尔茨海默病中作用及其影像学评价
张聪 等
磁共振成像 2018,09(07)
金属对金属人工全髋关节置换术后早期血清金属离子变化及对免疫功能的影响
陈哲峰 等
中华骨科杂志 2013,33(05)
MedAI助手（体验版）
文档即答
智问智答
机器翻译
回答内容由人工智能生成，我社无法保证其准确性和完整性，该生成内容不代表我们的态度或观点，仅供参考。
生成快照
文献快照

你好，我可以帮助您更好的了解本文，请向我提问您关注的问题。

0/2000

《中华医学会杂志社用户协议》 | 《隐私政策》

《SparkDesk 用户协议》 | 《SparkDesk 隐私政策》

网信算备340104764864601230055号 | 网信算备340104726288401230013号

技术支持：

历史对话
本文全部
还没有聊天记录
设置
模式
纯净模式沉浸模式
字号
小中大