综述
ENGLISH ABSTRACT
呼气末肺容积对上气道可塌陷性及阻塞性睡眠呼吸暂停的影响
董明林
胡卫华
胡克
作者及单位信息
·
DOI: 10.3760/cma.j.issn.1001-0939.2019.03.014
Effects of end⁃expiratory lung volume on pharyngeal collapsibility and obstructive sleep apnea
Dong Minglin
Hu Weihua
Hu Ke
Authors Info & Affiliations
Dong Minglin
Hu Weihua
Hu Ke
·
DOI: 10.3760/cma.j.issn.1001-0939.2019.03.014
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摘要

慢性阻塞性肺疾病(慢阻肺)与阻塞性睡眠呼吸暂停(OSA)并存时,被称为重叠综合征(OVS)。在病理生理学上,OVS是上气道塌陷(OSA)与过度充气(慢阻肺)的并存。已知上气道稳定性与呼气末肺容积(EELV)直接相关,肺充气程度是决定上气道稳定性的重要因素,增加反映肺充气程度的EELV可以减少OSA的发生,即前者对后者具有"保护性作用" 。

引用本文

董明林,胡卫华,胡克. 呼气末肺容积对上气道可塌陷性及阻塞性睡眠呼吸暂停的影响[J]. 中华结核和呼吸杂志,2019,42(3):222-226.

DOI:10.3760/cma.j.issn.1001-0939.2019.03.014

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慢性阻塞性肺疾病(慢阻肺)在我国40岁以上成年人群中的患病率达13.7% [ 1 ],已成为西方国家第三大死亡原因;而阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)不仅患病率高,且与多种心脑血管性疾病的发生和发展密切相关。近年研究结果表明,当OSA与慢阻肺合并存在时,可以增加慢阻肺的急性加重频率和住院次数,所致病死率高于单一疾病 [ 2 ]。美国胸科学会将重叠综合征(the overlap syndrome,OVS)这一术语专指OSA与慢阻肺的并存 [ 3 ]。从病理生理学角度来看,OVS是上气道塌陷(OSA)与过度充气(慢阻肺)的并存。诸多研究结果显示,上气道稳定性与呼气末肺容积(end-expiratory lung volume,EELV)直接相关,增加EELV可降低咽气道可塌陷性和改善OSA [ 4 ];反之,肺容积减少能降低对上气道的尾侧牵引和增加上气道可塌陷性 [ 5 ]
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备注信息
A
胡克,Email: mocdef.3ab61xjekuh
B
所有作者均声明不存在利益冲突
C
国家重点研发计划项目 (2016YFC1304403)
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