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运动训练对抗肿瘤治疗患者癌因性疲乏及生命质量影响的系统评价与Meta分析
郭苗苗
王丹若
袁玲
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1672-7088.2019.17.016
Effects of excise traning on cancer-related fatigue in patients undergoing anticancer treatment: a Meta-analysis of randomized controlled trails
Guo Miaomiao
Wang Danruo
Yuan Ling
Authors Info & Affiliations
Guo Miaomiao
Oncology Department, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
Wang Danruo
Yuan Ling
·
DOI： 10.3760/cma.j.issn.1672-7088.2019.17.016
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摘要

目的系统评价运动训练对缓解抗肿瘤治疗患者癌因性疲乏，提高生命质量的效果。

方法严格界定纳入排除标准，计算机检索中英文数据库中关于运动训练对抗肿瘤治疗患者进行干预的随机对照研究，由2名研究者对文献质量进行严格评价和资料提取，对符合质量标准的随机对照研究进行Meta分析。

结果共纳入随机对照试验9篇，其中英文7篇，中文2篇。有氧运动可提高患者生命质量（ SMD=1.17， P=0.002），缓解其癌因性疲乏的症状（ SMD=-1.14， P=0.000 2），并在干预后3~4周内同样有一定效应（ P < 0.05）；抗阻力训练或抗阻力运动与有氧运动结合并不能缓解患者癌因性疲乏症状（ SMD=-0.06， P=0.85），但能提高其生命质量（ SMD=0.39， P=0.002）。

结论抗肿瘤治疗患者应在专业人员的指导下进行有氧运动，以缓解自身癌因性疲乏症状，提高其生命质量。

生活质量;运动训练;抗肿瘤治疗;癌因性疲乏
ABSTRACT

ObjectiveTo investigate the effectiveness of excise training on cancer-related fatigue (CRF) and quality of life (QOL) in patients undergoing anticancer treatment.

MethodsEight databases (PubMed, Medline, Cochran Library, EMBASE, and four Chinese database) were searched to identify randomized controlled trials (RCTs) that evaluated the effects of excise training on CRF and QOL. The quality of literature was strictly evaluated and data extracted by 2 researchers. Meta-analysis was performed on randomized controlled trials that met the quality criteria.

ResultsNine RCTs involving 847 patients were included. Pooled results suggested that aerobic exercise can improve the QOL ( SMD=1.17, P=0.002), alleviate the symptoms of CRF ( SMD=-1.14, P=0.000 2), and also have a certain effect within 3-4 weeks after intervention ( P < 0.05); resistance training or anti resistance exercise combined with aerobic exercise can not alleviate the patients′ cancer induced fatigue symptoms ( SMD=-0.06, P=0.85), but it can improve the quality of life ( SMD=0.39, P=0.002).

ConclusionPatients with anticancer therapy should undergo aerobic exercise under the guidance of professional personnel to alleviate symptoms of cancer-related fatigue and improve their quality of life.

Quality of life;Exercise;Anticancer therapy;Cancer-related fatigue
Yuan Ling, Email: mocdef.labiamtoh37gnilnauy, Tel: 0086-25-83106666-61333
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引用本文

郭苗苗,王丹若,袁玲. 运动训练对抗肿瘤治疗患者癌因性疲乏及生命质量影响的系统评价与Meta分析[J]. 中国实用护理杂志,2019,35(17)：1350-1356.

DOI:10.3760/cma.j.issn.1672-7088.2019.17.016

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美国癌症网络（National Comprehensive Cancer Network，NCCN）把癌因性疲乏（cancer-related fatigue，CRF）定义为一种对疲乏的主观感觉，具有持续性及普遍性的特点，与癌症本身以及影响生理功能的癌症治疗有关 [ 1 ]。疲乏是接受抗肿瘤治疗患者最常见的症状，据报道，有80%~96%的化疗患者和60%~93%的放疗患者受到CRF的困扰 [ 2 , 3 , 4 ]，CRF不仅影响患者的生命质量，引起病情加重，而且会导致治疗中断 [ 5 ]。目前，对于治疗CRF尚无统一的标准 [ 6 ]。体育活动可以增加肌肉力量，改善肺功能增加心脏储备，从而改善患者疲乏症状，提高患者的生命质量 [ 7 ]。目前，许多研究就肿瘤患者实施运动训练做了相关研究，但对于运动形式、运动内容和运动时间等方面均不一致，且研究结果存在争议；有最新的系统评价 [ 8 , 9 ]总结了瑜伽和太极对肿瘤患者CRF的影响，但文中并未对干预人群做严格界定，同时纳入了积极接受抗肿瘤治疗和抗肿瘤治疗结束的患者。本研究对研究对象（population，P）、干预措施（intervention，I）、对照措施（comparison，C）、评价指标（outcome，O）、文献类型（style，S）均作了严格界定，对所检索到的文献进行系统评价，旨在为改善抗肿瘤治疗患者CRF提供更可靠的依据，现报道如下。
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袁玲，Email： mocdef.labiamtoh37gnilnauy，电话：025-83106666-61333
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