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ENGLISH ABSTRACT
曲安奈德后部眼球筋膜下注射与雷珠单抗玻璃体内注射治疗缺血性视神经病变的疗效对比
张振坡
张金嵩
杨倩倩
刘德成
郭春峰
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-1477.2019.06.012
Comparison of efficacy between subtenon injection of triamcinolone acetonide and intravitreal injection of ranibizumab for non-arteritic anterior ischenic optic neuropathy
Zhang Zhenpo
Zhang Jinsong
Yang Qianqian
Liu Decheng
Guo Chunfeng
Authors Info & Affiliations
Zhang Zhenpo
Department of Ophthalmology, Jia County People’s Hospital, Henan 467100, China
Zhang Jinsong
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yang Qianqian
Department of Ophthalmology, The Seventh People’s Hospital, Zhengzhou 450016, China
Liu Decheng
Department of Ophthalmology, The Seventh People’s Hospital, Zhengzhou 450016, China
Guo Chunfeng
Kaifeng Guangming Hospital, Kaifeng 475000, China
·
DOI： 10.3760/cma.j.issn.2095-1477.2019.06.012
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摘要

目的比较曲安奈德后部眼球筋膜下注射雷珠单抗玻璃体内注射治疗非动脉炎性前部缺血性视神经病变(NAION)的效果。

方法回顾性分析2016年6月至2018年6月临床确诊的NAION 60例(60眼)随机分为两组。A组30例(30眼)曲安奈德20 mg后部眼球筋膜下注射；B组30例(30眼)雷珠单抗玻璃体内注射；均为15天为1个疗程。观察治疗后视力、视盘水肿情况及视野。

结果治疗后15天，两组视力、视野及视盘水肿情况均有不同程度改善，后部眼球筋膜下注射组有视野检查15眼中治疗后好转14眼(93.33%)，1眼无变化(6.67%)。雷珠单抗玻璃体内注射组有视野检查记录的15眼中治疗后视野好转12眼(83.33%)，3眼无变化(16.67%)。

结论曲安奈德与雷珠单抗治疗NAION有同等的疗效。曲安奈德在经济学方面及安全方面优于雷珠单抗组。

视神经病变，缺血性，前部，非动脉炎性;曲安奈德，后部眼球筋膜下注射;雷珠单抗，玻璃体内注射
ABSTRACT

ObjectiveTo compare the efficary between posterior subtenon injection of triamcinolone acetonide(TA)and intravitreal injection of ranibizumab for the treatment of non-artertic anterior ischemic optic neuropathy (NAION).

MethodsTotal of 60 eyes of 60 patients who were diagnosed as NAION from Jun. 2016 to Jun. 2018 were randomly divided into two groups.Group A, 30 eyes of 30 patients, received poeterior subtenon injection of triamcinolone acetonide (TA, 20mg). Group B, 30 eyes of 30 cases, received intravitreal injection of ranibizumab. The visual acuity, visual field and optic disc edema were recorded after treatment.

ResultsThe visual acuity, visual field and optic disc edema at 15 days after treatment were improved.In group A the vision field improved in 14 eyes (93.33%)among 15 eyes who received visual field examination, unchannged in 1 eye (6.67%). In group B the vision field were improved in 12 eyes(83.33%)among 15 eyes who received visual field examination, and unchannged in 3 eyes(16.67%).

ConclusionTriamcinolone acetonide (TA) has the same efficacy as ranibizumab in the treatment of NAION.Triamcinolone acetonide are superior to Ranibizumab in economics and safety.

Neuropathy, optic, ischemic, anterior, non-arteritic;Triamcinolone acetonide, subtenon injection;Ranibizumab, intravitreal injection
Liu Decheng, Email: mocdef.3ab6102378CDL, Tel: 0371-89905020
Copyright by Chinese Medical Association
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引用本文

张振坡,张金嵩,杨倩倩,等. 曲安奈德后部眼球筋膜下注射与雷珠单抗玻璃体内注射治疗缺血性视神经病变的疗效对比[J]. 中华眼外伤职业眼病杂志,2019,41(6)：450-453.

DOI:10.3760/cma.j.issn.2095-1477.2019.06.012

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非动脉炎性前部缺血性视神经病变(non-arteritic anterior ischemic optic neuropathy，NAION)，是一种发病急、可累及双眼，视功能损害较重的常见眼病，以视力突然减退，扇形或半侧视野缺损和视盘水肿为临床特征的急性眼病。短期内即可发生视网膜神经节细胞丧失和不可逆转性视神经纤维受损，出现严重视功能障碍、甚至永久性视力丧失。目前该病主要利用血管扩张剂、糖皮质激素及复方樟柳碱等治疗，效果并不肯定 [ 1 ]。近年来作者通过雷珠单抗玻璃体内注射与曲安奈德后部眼球筋膜下注射治疗NAION，取得了良好效果。现报告如下。
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备注信息
A
刘德成，Email： mocdef.3ab6102378CDL，电话：0371-89905020
B
所有作者均声明不存在利益冲突
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