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银屑病与STAT3
陈怡雯
苏婷
苏忠兰
作者及单位信息
·
DOI： 10.3760/cma.j.issn.0412-4030.2019.07.014
Association between psoriasis and STAT3
Chen Yiwen
Su Ting
Su Zhonglan
Authors Info & Affiliations
Chen Yiwen
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Su Ting
Su Zhonglan
·
DOI： 10.3760/cma.j.issn.0412-4030.2019.07.014
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摘要

银屑病是一种慢性炎症性皮肤病，其发病机制尚不明确，目前认为由遗传、环境、免疫等共同介导。信号转导与转录激活因子3（STAT3）是一种重要的转录因子，与肿瘤、自身免疫性疾病等相关，通过参与Th17细胞分化、角质形成细胞过度增生与异常分化、与炎症细胞相互作用、真皮血管增生等重要病理过程在银屑病发病中起关键作用。近年来，针对STAT3及其上游JAK激酶治疗银屑病的研究显示出较好的有效性和安全性。本文就银屑病与STAT3的关系进行综述，为以STAT3为靶点治疗银屑病的可行性提供依据。

银屑病;STAT3转录因子;Janus激酶类;角蛋白细胞;发病机制;治疗
ABSTRACT

Psoriasis is a chronic inflammatory skin disease. Its pathogenesis remains unclear, and is currently considered to be co-mediated by heredity, environment and immunity. Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor, which is associated with cancer and autoimmune diseases. STAT3 plays a crucial role in the occurrence of psoriasis by participating in the differentiation of T helper 17 cells, hyperproliferation and abnormal differentiation of keratinocytes, interaction with inflammatory cells, hyperplasia of dermal vessels and other important pathological processes. In recent studies, therapies targeting STAT3 and its upstream Janus kinases (JAK) have shown good efficacy and safety in the management of psoriasis. This review summarizes the association between psoriasis and STAT3, so as to provide evidence for the feasibility of the treatment of psoriasis with targeted inhibition of STAT3.

Psoriasis;STAT3 transcription factor;Janus kinases;Keratinocytes;Pathogenesis;Therapy
Su Zhonglan, Email: mocdef.6ab215952us_ecila
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引用本文

陈怡雯,苏婷,苏忠兰. 银屑病与STAT3[J]. 中华皮肤科杂志,2019,52(7)：502-505.

DOI:10.3760/cma.j.issn.0412-4030.2019.07.014

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银屑病是一种常见的以红斑、鳞屑为主要临床表现的慢性复发性炎症性皮肤病，病因尚不明确，目前认为与遗传、环境、免疫等多种因素有关。近年发现，银屑病与心脑血管疾病 [ 1 ]、代谢综合征 [ 2 ]、精神心理疾病 [ 3 ]、淋巴瘤 [ 4 ]及炎症性肠病 [ 5 ]等具有相关性，因此认为银屑病已不仅仅是皮肤病，更是系统性的炎症性疾病。信号转导与转录激活因子3（signal transducer and activator of transcription 3，STAT3）是一种重要的转录因子，与肿瘤、自身免疫性疾病等相关。近年研究发现，STAT3在银屑病发病中起关键作用 [ 6 ]，本文就二者的关系作一综述。
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备注信息
A
苏忠兰，Email： mocdef.6ab215952us_ecila
B
所有作者均声明不存在利益冲突
C
国家自然科学基金 (81773326)
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