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ENGLISH ABSTRACT
妊娠期免疫系统的特点与妊娠合并自身免疫性疾病
刘洋腾宇
左晓霞
作者及单位信息
·
DOI： 10.3877/cma.j.issn.2095-3259.2019.02.009
Characteristics of the immune system during pregnancy and pregnancy with autoimmune diseases
Liu Yangtengyu
Zuo Xiaoxia
Authors Info & Affiliations
Liu Yangtengyu
Zuo Xiaoxia
·
DOI： 10.3877/cma.j.issn.2095-3259.2019.02.009
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摘要

妊娠是一个复杂的生理过程，其中免疫系统发生的一系列改变，是维持母体对胎儿这一"非己"成分的免疫耐受以及对外界刺激的正常应答。同时，在妊娠过程中某些自身免疫性疾病的发病率增加，或已经稳定的疾病在妊娠期间出现疾病活动或病情恶化，也与妊娠期间免疫系统的特殊变化密切相关。但其在妊娠期发生的确切机制尚不明确，本文通过复习文献对妊娠期免疫系统的变化特点及妊娠期合并自身免疫性疾病的免疫学基础进行讨论。

自身免疫疾病;免疫系统;妊娠
ABSTRACT

Pregnancy is a complex physiological process in which a series of changes in the immune system is to maintain the mother′s immune tolerance to the " non-self" component of the fetus and the normal response to external stimuli. At the same time, during pregnancy, the incidence of certain autoimmune diseases increases, or stable disease develops or progresses, which are also closely related to the special changes in the immune system during pregnancy. However, the exact mechanism of its occurrence during pregnancy is still unclear. This article reviews the literature on the changes in the immune system during pregnancy and the immunological basis of autoimmune diseases in pregnancy.

Autoimmune diseases;Immune system;Pregnancy
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引用本文

刘洋腾宇,左晓霞. 妊娠期免疫系统的特点与妊娠合并自身免疫性疾病[J/OL]中华产科急救电子杂志,2019,8(2)：103-107.

DOI:10.3877/cma.j.issn.2095-3259.2019.02.009

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育龄女性妊娠时机体会发生一系列生理变化，在这一过程中免疫系统也会发生一系列复杂的改变，而使其能够维持正常妊娠以及在发生妊娠异常时机体对其作出应答，同时也可能发生异常改变，即发生一系列与自身免疫相关的疾病，如系统性红斑狼疮、抗磷脂综合征、肾病综合征、1型糖尿病等，严重威胁母儿安全。而发生妊娠合并自身免疫性疾病的确切机制尚不明确，本文通过复习文献，对妊娠期免疫系统的变化特点及妊娠期合并自身免疫性疾病的免疫学基础进行讨论。
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备注信息
A
左晓霞，Email: mocdef.labiamtohouznasus
B

刘洋腾宇，左晓霞.妊娠期免疫系统的特点与妊娠合并自身免疫性疾病[J/CD].中华产科急救电子杂志，2019, 8(2): 103－107.

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