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外泌体在支气管哮喘发病机制中的作用
戴伟
吴海兰
赵明
辛晓峰
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1001-0939.2020.01.015
The role of exosomes in the pathogenesis of asthma
Dai Wei
Wu Hailan
Zhao Ming
Xin Xiaofeng
Authors Info & Affiliations
Dai Wei
Wu Hailan
Zhao Ming
Xin Xiaofeng
·
DOI： 10.3760/cma.j.issn.1001-0939.2020.01.015
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摘要

支气管哮喘（哮喘）是一种气道慢性炎症性疾病，外泌体是近年来研究的热点，随着对外泌体研究的逐渐深入，发现其在哮喘的气道炎症中发挥调节作用，本文从外泌体的结构和功能为切入点，对其在哮喘发病机制中的作用进行综述。

引用本文

戴伟,吴海兰,赵明,等. 外泌体在支气管哮喘发病机制中的作用[J]. 中华结核和呼吸杂志,2020,43(1)：67-70.

DOI:10.3760/cma.j.issn.1001-0939.2020.01.015

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支气管哮喘（哮喘）是一种常见的慢性气道炎症性疾病，这种慢性炎症反应是由肺结构细胞（如上皮细胞、成纤维细胞及内皮细胞等）、炎症细胞（如嗜酸粒细胞、肥大细胞、嗜中性粒细胞及T-淋巴细胞等）和炎性介质等共同参与、相互作用的结果 [ 1 ]。外泌体是纳米大小由膜包绕的囊泡，其可通过旁分泌等途径在细胞间传递信息并调节受体细胞功能 [ 2 ]。近年的研究结果显示，外泌体参与哮喘的炎症反应，诱导炎症细胞的迁移，提示其在哮喘的发生、发展中发挥作用 [ 3 , 4 ]。本文拟从外泌体的结构和功能入手，阐述其在哮喘发病机制中的作用。
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备注信息
A
辛晓峰，Email： mocdef.aabnis6011_fxx
B
所有作者均声明不存在利益冲突
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