首页 中华结核和呼吸杂志 2020年43卷03期 白细胞介素33在支气管哮喘中的作用及其研究现状
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白细胞介素33在支气管哮喘中的作用及其研究现状
柳亚慧 
黄春容
时国朝 
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1001-0939.2020.03.024
The role of interleukin 33 in bronchial asthma and its current research status
Liu Yahui
Huang Chunrong
Shi Guo Chao
Authors Info & Affiliations
Liu Yahui
Huang Chunrong
Shi Guo Chao
·
DOI： 10.3760/cma.j.issn.1001-0939.2020.03.024
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摘要
支气管哮喘（哮喘）是一种复杂的异质性疾病，多以2型反应为主。近年来随着科技发展人们对哮喘的病理生理学机制有了长足的认识，气道上皮细胞来源的细胞因子白细胞介素33（interleukin 33，IL-33）在哮喘的发生和发展中发挥重要作用。本文立足于IL-33，结合其本身的生物学特点和发挥作用的靶细胞，综述IL-33在哮喘的气道炎症和气道重塑中的作用。
引用本文
柳亚慧,黄春容,时国朝. 白细胞介素33在支气管哮喘中的作用及其研究现状[J]. 中华结核和呼吸杂志,2020,43(03)：250-255.
DOI:10.3760/cma.j.issn.1001-0939.2020.03.024PERMISSIONS
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哮喘是最常见的慢性气道疾病之一，我国哮喘患病率仍逐年上升
[
1
]。气道上皮是人体抵御外界刺激的第一道屏障，在哮喘的病理生理过程中发挥关键作用。哮喘患者上皮细胞受到刺激后可诱导2型反应，导致慢性气道炎症与气道重塑。气道上皮诱导2型反应依赖于上皮细胞分泌的细胞因子，如IL-33、IL-25、胸腺基质淋巴细胞生成素（thymic stromal lymphopoietin，TSLP）等。现已证实IL-33是一种强大的炎性因子，IL-33与其受体结合后，使靶细胞释放大量趋化因子和细胞因子，导致2型反应，在哮喘等过敏性疾病中发挥重要作用。本文从IL-33的结构特点、表达与分泌、活性调节、受体与信号通路、靶细胞及临床应用等方面综述IL-33在支气管哮喘中的作用。
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