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ENGLISH ABSTRACT
角膜胶原交联术治疗角膜病的新进展
贾桂祯
程梦雅 [综述]
王林农 [综述]
作者及单位信息
·
DOI： 10.3760/cma.j.issn.2095-0160.2020.03.016
Research advances of corneal collagen cross-linking in the treatment of corneal diseases
Jia Guizhen
Cheng Mengya
Wang Linnong
Authors Info & Affiliations
Jia Guizhen
Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China (is working at Department of Ophthalmology, Childern's Hospital of Nanjing Medical University, Nanjing 210008, China)
Cheng Mengya
Wang Linnong
·
DOI： 10.3760/cma.j.issn.2095-0160.2020.03.016
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摘要

角膜胶原交联术( CXL)对阻止扩张性角膜病、感染性角膜病、屈光不正的发展具有较好的安全性和有效性。常见 CXL有常规胶原交联术、加速胶原交联术、跨上皮胶原交联术、激光化学反应胶原交联术以及联合手术。 CXL可有效阻止扩张性角膜病进展，可延迟或避免角膜移植手术的治疗，并在大泡性角膜病、除疱疹病毒性感染外的感染性角膜炎、屈光不正等其他角膜病的治疗中均有较好的辅助作用，但对于眼部疱疹病毒性感染的患者及薄角膜的患者效果不佳，甚至会加重病情发展。本文就常见 CXL手术方式的优缺点、适应症、禁忌症以及并发症进行综述，以期增强 CXL的临床应用，减少其并发症。

角膜胶原交联术;扩张性角膜病;感染性角膜病;屈光不正
ABSTRACT

Corneal collagen cross-linking (CXL) has been proved to be a very safe and effective technique to halt the progression of many cornea diseases, such as ectasia disease, infectious keratitis and ametropia.CXL techniques include conventional CXL, accelerated CXL, transepithelial CXL and photochemical CXL.CXL can prevent the progression of dilated keratopathy, postpone or avoid corneal transplant surgery, and has an auxiliary function in the treatment of bullous keratopathy, infectious keratitis except herpes virus infection, and ametropia.CXL is not effective for patients with ocular herpes virus infection and patients with thin cornea and may even worsen the development of the disease.This review summarized the advantages and disadvantages of common CXL techniques, indications, contraindications, and complications, which may help enhancing the clinical application of CXL and reducing its complications.

Corneal collagen cross-linking;Ectasia disease;Infectious Keratitis;Ametropia
Wang Linnong, Email: mocdef.nabuyilagnawgnonnil
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引用本文

贾桂祯,程梦雅,王林农. 角膜胶原交联术治疗角膜病的新进展[J]. 中华实验眼科杂志,2020,38(03)：245-249.

DOI:10.3760/cma.j.issn.2095-0160.2020.03.016

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20世纪90年代末 Sporl等 [ 1 ]始创了角膜胶原交联术( corneal collagen cross- linking， CXL)，该方法可利用370 nm的紫外光 A( ultraviolet A， UVA)照射经光敏剂核黄素(维生素 B2)浸润的角膜，增强了角膜胶原纤维机械强度、生物学稳定性及抗扩张能力 [ 2 , 3 ]。目前， CXL被认为是一种能够阻止以圆锥角膜为代表的扩张性角膜病发展的治疗手段。此外， CXL对某些感染性角膜病及屈光不正等也有一定的治疗作用。
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