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ENGLISH ABSTRACT
肿瘤坏死因子调控下MeCP2与增生性玻璃体视网膜病变发病的关联
徐月娟
李晓华 [综述]
作者及单位信息
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DOI： 10.3760/cma.j.cn115989-20191111-00491
Association between MeCP2 and proliferative vitreoretinopathy under the regulation of tumor necrosis factor
Xu Yuejuan
Li Xiaohua
Authors Info & Affiliations
Xu Yuejuan
Department of Ophthalmology, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, Henan University People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China
Li Xiaohua
Department of Ophthalmology, Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Henan Key Laboratory of Ophthalmology and Visual Science, Henan University People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China
·
DOI： 10.3760/cma.j.cn115989-20191111-00491
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摘要

增生性玻璃体视网膜病变(PVR)是由多种细胞因子参与的眼底疾病，其重要的病理过程是视网膜色素上皮(RPE)细胞的上皮－间充质转化(EMT)。肿瘤坏死因子(TNF)是一种重要的炎性反应诱导因子，可由活化的RPE细胞、小胶质细胞、单核细胞和巨噬细胞产生，进而参与PVR发生和发展过程。除了细胞因子之外，表观遗传学因素如DNA甲基化也在PVR的发生中起了重要作用，其中甲基CpG结合蛋白(MeCP2)参与EMT及纤维化，且在PVR膜中有较高的表达，转化的RPE细胞和小胶质细胞也存在MeCP2的阳性表达，推测MeCP2在PVR发生和发展过程中具有重要作用。TNF也可刺激MeCP2的表达。因此，本文就MeCP2在PVR形成中的作用以及TNF与MeCP2之间的交互反应在PVR形成中的作用进行综述。

肿瘤坏死因子;MeCP2;DNA甲基化;增生性玻璃体视网膜病变;表观遗传学
ABSTRACT

Proliferative vitreoretinopathy (PVR) is an ocular fundus disease involving multiple cytokines.Its important pathological process is epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells.Tumor necrosis factor (TNF) is an important inflammatory response inducing factor, which can be produced by activated RPE cells, microglia, monocytes and macrophages, and then participate in the occurrence and development of PVR.In addition to cytokines, epigenetic factors such as DNA methylation also play an important role in the development of PVR, in which methyl-CpG binding protein 2(MeCP2) is involved in EMT and fibrosis, and is highly expressed in PVR membrane.The positive expression of MeCP2 is also found in transformed RPE cells and microglia.It is speculated that MeCP2 plays an important role in the occurrence and development of PVR.TNF can also stimulate the expression of MeCP2.This article reviews the role of MeCP2 and the interaction between TNF and MeCP2 in the formation of PVR.

Tumor necrosis factor;MeCP2;DNA methylation;Proliferative vitreoretinopathy;Epigenetics
Li Xiaohua, Email: mocdef.3ab616116_lhx
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引用本文

徐月娟,李晓华. 肿瘤坏死因子调控下MeCP2与增生性玻璃体视网膜病变发病的关联[J]. 中华实验眼科杂志,2020,38(06)：548-552.

DOI:10.3760/cma.j.cn115989-20191111-00491

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增生性玻璃体视网膜病变(proliferative vitreoretinopathy，PVR)是视网膜脱离及修复术后的严重并发症，也是孔源性视网膜脱离手术失败常见的原因。患者表现为视力下降甚至失明，严重影响患者的生活质量。PVR的特点是视网膜表面和玻璃体腔广泛增生膜的形成 [ 1 , 2 ]。目前，PVR的主要治疗方式是手术治疗，但其成功率仅为60%～75% [ 3 ]。寻找更加安全有效的PVR治疗方法是目前亟待解决的问题。本文将着重讨论肿瘤坏死因子(tumor necrosis factor，TNF)、甲基CpG结合蛋白2(methyl-CpG binding protein 2，MeCP2)及其与PVR发展之间的关联，展望新的治疗靶点在PVR临床诊治中的应用。
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李晓华，Email： mocdef.3ab616116_lhx
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所有作者均声明不存在利益冲突
C
国家自然科学基金面上项目 (81770952)
河南省自然科学基金面上项目 (162300410296)
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