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铁自噬相关基因的研究进展
于宁宁
刘乃国
作者及单位信息
·
DOI： 10.3760/cma.j.cn231536-20200220-00011
Research advance in ferritinophagy-related genes
Yu Ningning
Liu Naiguo
Authors Info & Affiliations
Yu Ningning
Clinical Medicine Laboratory, Binzhou Medical University Affiliated Hospital, Binzhou 256603, China
Liu Naiguo
Clinical Medicine Laboratory, Binzhou Medical University Affiliated Hospital, Binzhou 256603, China
·
DOI： 10.3760/cma.j.cn231536-20200220-00011
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摘要

铁自噬(ferritinophagy)是细胞选择性自噬的一种类型，该过程由核受体辅激活因子4(nuclear receptor coativator 4，NCOA4)介导，使铁蛋白(主要是铁蛋白重链1)在自噬体中降解，导致铁蛋白结合的铁释放出来成为游离铁。铁自噬与新发现的细胞死亡形式——铁死亡有着一定的联系，在肿瘤发生中具有一定作用。本文介绍了铁自噬的概念及其相关基因，并对铁自噬相关基因在铁死亡和肿瘤发生中的作用进行了综述，以期为相关肿瘤的治疗提供一种新的思路。

铁自噬;NCOA4;FTH1;铁死亡;肿瘤
ABSTRACT

Ferritinophagy is a type of cell-selective autophagy, which is mediated by nuclear receptor coactivator 4(NCOA4). Its result is the degradation of ferritin, mainly ferritin heavy chain 1(FTH1)in the autophagosome, and the release of free iron from ferritin-bound iron. Ferritinophagy is associated with ferroptosis, a newly-discovered form of cell death that is involved in tumorigenesis. This paper reviews the concept of ferritinophagy and its related genes as well as the role of ferritinophagy-related genes in ferroptosis and tumorigenesis, thereby providing a new idea for the treatment of related tumors.

Ferritinophagy;NCOA4;FTH1;Ferroptosis;Tumor
Liu Naiguo, Email: mocdef.3ab616691ougianuil
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引用本文

于宁宁,刘乃国. 铁自噬相关基因的研究进展[J]. 国际遗传学杂志,2020,43(03)：180-184.

DOI:10.3760/cma.j.cn231536-20200220-00011

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2014年，Mancias等 [ 1 ]通过自噬体分离和定量蛋白质组学的结合已经确定核受体辅激活因子(nuclear recepior coativatior 4，NCOA4)是负责自噬依赖性铁蛋白降解的货物受体，很可能是因为NCOA4的C末端结合了吞噬体中FTH1上的一个保守的表面精氨酸(R23)，随后在自噬体和自噬溶酶体中结合，将其命名为铁自噬(ferritinophagy)。研究发现铁自噬介导的铁死亡与肝纤维化和神经退行性疾病有关 [ 2 , 3 ]，在特定情况下可用于杀死癌症 [ 4 , 5 ]。
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备注信息
A
刘乃国，Email： mocdef.3ab616691ougianuil
B
所有作者均声明不存在利益冲突
C
山东省自然科学基金立项课题 (ZR2019MC019)
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