ObjectiveTo evaluate the efficacy of atrial septostomy in idiopathic pulmonary arterial hypertension(IPAH) patients complicating right ventricular failure.

MethodsThis retrospective analysis included 5 IPAH patients (3 males, (29.3±15.2) years old) with right ventricular failure which were refractory to conventional and target-specific medication in Shanghai Chest Hospital from March to July 2014. Graded balloon dilation septostomy procedures were performed in all 5 patients.

ResultsSuccessful atrial septostomy was achieved in 5 attempts with no procedure-related complications. Immediately post procedure, the mean systemic oxygen saturation decreased from (98.0±1.8)% to (86.4±3.2)% ( P=0.002), while the mean right atrial pressure decreased from (18.9±1.7) mmHg (1 mmHg=0.133 kPa) to (16.0±1.3) mmHg ( P=0.039) and the mean cardiac index increased from (2.1±0.3) L·min ^-1·m ^-2 to (2.7±0.5) L·min ^-1·m ^-2 ( P=0.029). Mean follow-up was (6.2 ±1.8) months. Cardiac functional class (WHO) was 3 in 3 patients and 4 in 2 patients before the procedure, and increased 1 class in all patients during follow-up ( P=0.062). Exercise endurance (6-min walk test) also improved from (289.2±16.9) m to (320.4±19.6) m ( P=0.019), while B-type natriuretic peptide (BNP) level declined from (550.0±35.7) ng/L to (218.0±36.2) ng/L ( P<0.001). Except one patient developed spontaneous closure of created defect, right to left shunt at atrial septal level was evidenced by echocardiography during follow-up in the rest 4 patients.

ConclusionsAtrial septostomy is safe and can improve hemodynamics and heart function in selected IPAH patients with right heart failure. Atrial septostomy can be used as a palliative treatment for IPAH and further study is warranted to evaluate the long-term efficacy of this procedure.