加味金黄散熏洗预防索拉菲尼所致手足皮肤反应的疗效观察

祝朝富; 李卓虹; 李强; 李丹; 安佰平

doi:10.3760/cma.j.issn.1008-6706.2016.10.020

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中国基层医药

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ENGLISH ABSTRACT

加味金黄散熏洗预防索拉菲尼所致手足皮肤反应的疗效观察

作者及单位信息

出版日期： 2016 -05 -15 ·

DOI： 10.3760/cma.j.issn.1008-6706.2016.10.020

Observation of the clinical effects of Jiawei Jinhuang powder with fumigation-washing applied for hand-foot skin reaction caused by sorafenib

Authors Info & Affiliations

Zhu Chaofu

Department of Oncology, the Affiliated Hospital of Chengdu University of TCM, Chengdu, Sichuan 610072, China

Li Zhuohong

Li Qiang

Li Dan

An Baiping

Published： 2016 -05 -15 ·

DOI： 10.3760/cma.j.issn.1008-6706.2016.10.020

APP内阅读

摘要

目的观察加味金黄散熏洗预防索拉菲尼所致手足皮肤反应(HFSR)的临床疗效。

方法将服用索拉菲尼的患者设为加味金黄散熏洗的治疗组和口服维生素B ₆的对照组，每组各24例。8周后对两组HFSR发病率及分级进行统计对照分析。

结果治疗组和对照组HFSR发生率、HFSR Ⅱ～Ⅲ发生率比较差异有统计学意义(29.17%比70.83%，χ ²＝8.375， P<0.05；12.50%比33.33%， P<0.05)。

结论加味金黄散能显著降低索拉菲尼所致手足皮肤反应的发生率及减轻手足反应。

关键词：手足皮肤反应;加味金黄散;索拉菲尼

ABSTRACT

ObjectiveTo investigate associate chief physician the clinical effects of Jiawei Jinhuang powder with fumigation-washing on hand-foot skin reaction(HFSR) caused by sorafenib.

Methods48 patients who received sorafenib were randomly divided into two groups.24 patients in the treatment group were administered Jiawei Jinhuang powder with fumigation-washing, and another 24 patients in the control group were given VitB ₆ orally.After 8 weeks, the incidence and grade of HFSR were statistically studied between the two groups.

ResultsThere was significant differences of hand-foot reaction between the treatment group and the control group (incidence rate: 29.17% vs 70.83%, χ ²=8.375, P<0.05; The incidence rate of Ⅱ-Ⅲ: 12.50% vs 33.33%, P<0.05).

ConclusionJiawei Jinhuang powder with fumigation-washing could remarkably reduce the incidence rate of HFSR caused by sorafenib.

KEYWORDS： Hand-foot skin reaction;Jiawei Jinhuang powder;Sorafenib

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All articles published represent the opinions of the authors, and do not reflect the official policy of the Chinese Medical Association or the Editorial Board, unless this is clearly specified.

引用本文

祝朝富,李卓虹,李强,等. 加味金黄散熏洗预防索拉菲尼所致手足皮肤反应的疗效观察[J]. 中国基层医药,2016,23(10)：1510-1512.

DOI:10.3760/cma.j.issn.1008-6706.2016.10.020

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手足皮肤反应(Hand-foot skin reaction，HFSR)，多出现于接受分子靶向药物如索拉菲尼、吉非替尼等治疗的肿瘤患者中。其临床症状多表现为四肢麻木、瘙痒、感觉迟钝、感觉异常、麻刺感、无痛感或疼痛感，或皮肤肿胀、红斑、渗液，甚至皮肤脱屑、皲裂、硬结样水泡或严重的疼痛等。不仅影响了患者的日常生活，也限制了相关药物的长期使用，给患者的生活及治疗均带来了较大的影响。但目前临床对于HFSR的预防及治疗尚无参照标准，且目前所使用的种种措施也未取得令人满意的结果。因此，笔者所在科室根据中医理论基础拟定加味金黄散予以熏洗四肢的治疗方式，以预防索拉菲尼所致的手足皮肤反应，并通过对3年时间内我科室服用索拉菲尼的患者进行临床研究，取得了较为显著的效果，现报告如下。

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