首页 中华结核和呼吸杂志 2020年43卷12期 支气管哮喘防治指南（2020年版）
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支气管哮喘防治指南（2020年版）
中华医学会呼吸病学分会哮喘学组 
作者及单位信息
·
DOI： 10.3760/cma.j.cn112147-20200618-00721
Guidelines for bronchial asthma prevent and management(2020 edition) Asthma group of Chinese Throacic Society
Asthma group of Chinese Throacic Society
Zhou Xin
Zhou Xin
Zhong Nanshan
Authors Info & Affiliations
Asthma group of Chinese Throacic Society
Zhou Xin
Zhou Xin
Zhong Nanshan
·
DOI： 10.3760/cma.j.cn112147-20200618-00721
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摘要
支气管哮喘（哮喘）是一种常见的慢性呼吸道疾病，临床研究结果表明，哮喘的规范化诊断和治疗，特别是实施有效的管理，对于提高哮喘的控制水平，改善患者生活质量具有重要作用。支气管哮喘防治指南（2020年版）是在我国既往哮喘防治指南的基础上，结合近年来国内外循证医学研究结果，由我国哮喘学组数十位专家集体讨论而重新修订。本指南旨在为提高我国医务人员对哮喘规范化诊治的认识和水平，提供指导性文件。
哮喘;预防;诊断;治疗;管理
ABSTRACT
Bronchial asthma is a common chronic respiratory disease. Clinical studies have shown that standardized diagnosis and treatment of asthma, especially effective management, are important for improving the asthma control and the quality of life of patients. The guideline for the prevention and treatment of bronchial asthma (2020 edition) were based on the previous guidelines for the prevention and treatment of asthma in China and combined with the results of evidence-based medicine research at China and other countries/regiongs in recent years. The guideline is intended to provide guidance documents for improving the understanding and standardized diagnosis and treatment of asthma among medical doctors in China.
Bronchial asthma;Prevention;Diagnosis;Treatment;Management
Zhou Xin, Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China, Email:
mocdef.3ab6135uohzx
Shenhuahao, Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Zhejiang University Medical College, 310009, China, Email:
mocdef.3ab61nehsoahauh
Zhong Nanshan, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the first Affiliated Hospital of Guangzhou Medical University, National Clinal Research Center for Respiratory Disease, Guangzhou 510120, China, Email:nanshan @vip.163.com
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引用本文
中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南（2020年版）[J]. 中华结核和呼吸杂志,2020,43(12)：1023-1048.
DOI:10.3760/cma.j.cn112147-20200618-00721PERMISSIONS
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更正
本文中在哮喘诊断标准中，可变气流受限的客观检查：“支气管舒张试验阳性（吸入支气管舒张剂后，FEV1增加＞12%，且FEV1绝对值增加＞200 ml），或抗炎治疗4周后与基线值比较FEV1增加＞200 ml,且FEV1绝对值增加＞200 ml（除外呼吸道感染）”应更正为“吸入支气管舒张剂后，FEV1增加≥12%，且FEV1绝对值增加≥200 ml），或抗炎治疗4周后与基线值比较FEV1增加≥200 ml,且FEV1绝对值增加≥200 ml（除外呼吸道感染）”。更正的同时表示歉意！
支气管哮喘（哮喘）是常见的慢性呼吸道疾病，近年来其患病率在全球范围内有逐年增加的趋势。临床研究和实践结果表明，哮喘的规范化诊断和治疗，特别是实施有效的管理，对于提高哮喘的控制水平，改善患者生活质量具有重要作用。中华医学会呼吸病学分会哮喘学组于2003、2008和2016年三次修订了我国的“支气管哮喘防治指南”，作为指导性文件对于推动我国的哮喘防治工作发挥了积极的作用
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支气管哮喘防治指南（2020年版）是在我国既往哮喘防治指南基础上，结合近年来国内外循证医学研究结果，由我国哮喘学组数十位专家集体讨论而重新修订。本指南旨在为提高我国医务人员对哮喘规范化诊治的认识和水平，提供指导性文件。
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参考文献
1
中华医学会呼吸病学分会哮喘学组,支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J]. 中华结核和呼吸杂志, 2003,26(3):132-138. DOI:
10.3760/j:issn:1001-0939.2003.03.003
.
2
中华医学会呼吸病学分会哮喘学组,支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[J]. 中华结核和呼吸杂志, 2008,31(3):177-185. DOI:
10.3321/j.issn:1001-0939.2008.03.007
.
3
中华医学会呼吸病学分会哮喘学组,支气管哮喘防治指南(2016年版)[J]. 中华结核和呼吸杂志, 2016,39(9):675-697. DOI:
10.3760/cma.j.issn.1001-0939.2016.09.007
.
4
GBD 2015 Chronic Respiratory Disease Collaborators. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet Respir Med. 2017,5(9):691-706. DOI:
10.1016/S2213-2600(17)30293-X
.
5
Song, WJ , Kang MG , Chang YS ,et al. Epidemiology of adult asthma in Asia: toward a better understanding[J]. Asia Pac Allergy, 2014,4(2):75-85. DOI:
10.5415/apallergy.2014.4.2.75
.
6
Lin J , Wang W , Chen P ,et al. Prevalence and risk factors of asthma in mainland China: The CARE study[J]. Respir Med, 2018,137:48-54. DOI:
10.1016/j.rmed.2018.02.010
.
7
Huang K , Yang T , Xu J ,et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study[J]. Lancet, 2019,394(10196):407-418. DOI:
10.1016/S0140-6736(19)31147-X
.
8
Global Initiative for Asthma. Global strategy for asthma management and prevention:update 2019[EB/OL]. [ 2019-04-13]. http://www.ginaasthma.org/.
9
Price D , Fletcher M , van der Molen T . Asthma control and management in 8, 000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey[J]. NPJ Prim Care Respir Med, 2014,24:14009. DOI:
10.1038/npjpcrm.2014.9
.
10
Su N , Lin J , Chen P ,et al. Evaluation of asthma control and patient′s perception of asthma: findings and analysis of a nationwide questionnaire-based survey in China[J]. J Asthma, 2013,50(8):861-870. DOI:
10.3109/02770903.2013.808346
.
11
Zhong N , Lin J , Zheng J ,et al. Uncontrolled asthma and its risk factors in adult Chinese asthma patients[J]. Ther Adv Respir Dis, 2016,10(6):507-517. DOI:
10.1177/1753465816663978
.
12
Haselkorn, T , Chen H , Miller DP ,et al. Asthma control and activity limitations: insights from the Real-world Evaluation of Asthma Control and Treatment (REACT) study[J]. Ann Allergy Asthma Immunol, 2010,104(6):471-477. DOI:
10.1016/j.anai.2010.04.006
.
13
林江涛,王文巧,周新,等. 我国30个省市城区门诊支气管哮喘患者控制水平的调查结果[J]. 中华结核和呼吸杂志, 2017,40(7):494-498. DOI:
10.3760/cma.j.issn.1001-0939.2017.07.002
.
14
Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention:update 2015[EB/OL]. [ 2015-11-10]. http://www.ginaasthma.org/.
15
Corrao WM , Braman SS , Irwin RS . Chronic cough as the sole presenting manifestation of bronchial asthma[J]. N Engl J Med, 1979,300(12):633-637. DOI:
10.1056/NEJM197903223001201
.
16
Shen H , Hua W , Wang PL ,et al. A new phenotype of asthma: chest tightness as the sole presenting manifestation[J]. Ann Allergy Asthma Immunol, 2013,111(3):226-227. DOI:
10.1016/j.anai.2013.06.016
.
17
Zhong NS , Chen RC , Yang MO ,et al. Is asymptomatic bronchial hyperresponsiveness an indication of potential asthma? A two-year follow-up of young students with bronchial hyperresponsiveness[J]. Chest, 1992,102(4):1104-1109. DOI:
10.1378/chest.102.4.1104
.
18
Shaaban R , Zureik M , Soussan D ,et al. Rhinitis and onset of asthma: a longitudinal population-based study[J]. Lancet, 2008,372(9643):1049-1057. DOI:
10.1016/S0140-6736(08)61446-4
.
19
Reddel HK , Taylor DR , Bateman ED ,et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice[J]. Am J Respir Crit Care Med, 2009,180(1):59-99. DOI:
10.1164/rccm.200801-060ST
.
20
Chung KF , Sally EW , Jan LB ,et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma[J]. Eur Respir J, 2014,43(2):343-373. DOI:
10.1183/13993003.52020-2013
.
21
Zhou X , Ding FM , Lin JT ,et al. Validity of asthma control test for asthma control assessment in Chinese primary care settings[J]. Chest, 2009,135(4):904-910. DOI:
10.1378/chest.08-0967
.
22
任旭斌,刘春涛,黄玉芳,等. 呼出气一氧化氮检测对支气管哮喘的诊断价值[J]. 中国呼吸与危重监护杂志, 2009,8(4):322-326. DOI:
10.3969/j.issn.1671-6205.2009.04.003
.
23
Dweik,RA, Boggs PB , Erzurum SC ,et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications[J]. Am J Respir Crit Care Med, 2011,184(5):602-615. DOI:
10.1164/rccm.9120-11ST
.
24
中国医师协会呼吸医师分会. 无创气道炎症评估支气管哮喘的临床应用中国专家共识[J]. 中华结核和呼吸杂志, 2015,38(5):329-341. DOI:
10.3760/cma.j.issn.1001-0939.2015.05.004
.
25
杜文,王丹,张兰兰,等. 支气管哮喘患者单次给药后呼出气一氧化氮的动态变化及其意义[J]. 中华结核和呼吸杂志, 2015,38(8):623-624. DOI:
10.3760/cma.j.issn.1001-0939.2015.08.016
.
26
Petsky HL , Cates CJ , Lasserson TJ ,et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers(exhaled nitric oxide or sputum eosinophils)[J]. Thorax, 2012,67(3):199-208. DOI:
10.1136/thx.2010.135574
.
27
蒋延文,孙永昌,周庆涛,等. 支气管哮喘患者痰嗜酸粒细胞相对计数与糖皮质激素治疗反应性的关系[J]. 中华结核和呼吸杂志, 2007,30(6):447-451. DOI:
10.3760/j.issn:1001-0939.2007.06.013
.
28
Zhang XY , Simpson JL , Powell H ,et al. Full blood count parameters for the detection of asthma inflammatory phenotypes[J]. Clin Exp Allergy, 2014,44(9):1137-1145. DOI:
10.1111/cea.12345
.
29
Liang Z , Zhao H , Lv Y ,et al. Moderate accuracy of peripheral eosinophil count for predicting eosinophilic phenotype in steroid-naive non-atopic adult asthmatics[J]. Intern Med, 2012,51(7):717-722. DOI:
10.2169/internalmedicine.51.6834
.
30
中华医学会变态反应分会,中华医学会呼吸病学分会哮喘学组. 中国过敏性哮喘诊治指南(第一版,2019年)[J]. 中华内科杂志, 2019,58(9):636-654. DOI:
10.3760/cma.j.issn
.
31
Haahtela, T , Tuomisto LE , Pietinalho A ,et al. A 10 year asthma programme in Finland: major change for the better[J]. Thorax, 2006,61(8):663-670. DOI:
10.1136/thx.2005.055699
.
32
Gibson PG , Powell H , Ducharme FM . Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations[J]. J Allergy Clin Immunol, 2007,119(2):344-350. DOI:
10.1016/j.jaci.2006.10.043
.
33
Bateman ED , Reddel HK , Eriksson G ,et al. Overall asthma control: the relationship between current control and future risk[J]. J Allergy Clin Immunol, 2010,125(3):600-608, 608.e1-608.e6. DOI:
10.1016/j.jaci.2009.11.033
.
34
Weatherall M , Wijesinghe M , Perrin K ,et al. Meta-analysis of the risk of mortality with salmeterol and the effect of concomitant inhaled corticosteroid therapy[J]. Thorax, 2010,65(1):39-43. DOI:
10.1136/thx.2009.116608
.
35
Ducharme FM , Ni Chroinin M , Greenstone I ,et al. Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma[J]. Cochrane Database Syst Rev, 2010, (4):CD005533. DOI:
10.1002/14651858.CD005533.pub2
.
36
Lazarinis N , Jørgensen L , Ekström T ,et al. Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction[J]. Thorax, 2014,69(2):130-136. DOI:
10.1136/thoraxjnl-2013-203557
.
37
Philip G , Nayak AS , Berger WE ,et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis[J]. Curr Med Res Opin, 2004,20(10):1549-1558. DOI:
10.1185/030079904x3348
.
38
Barnes PJ . Theophylline[J]. Am J Respir Crit Care Med, 2013,188(8):901-906. DOI:
10.1164/rccm.201302-0388PP
.
39
Zhong N . Management of asthma in developing countries// Barnes PJ , grunstein MM , Leff AR ,et al. Asthma[M], 1997:1869-1881.
40
李靖,莫红英,黄海露. 小剂量皮质类固醇吸入合并小剂量茶碱口服对支气管哮喘的治疗作用[J]. 中华结核和呼吸杂志, 2000,23(6):336. DOI:
10.3760/j:issn:1001-0939.2000.06.005
.
41
黄海鹭,孙宝清,李靖. 低剂量皮质类固醇吸入结合口服茶碱对哮喘患者骨钙素及嗜酸细胞阳离子蛋白水平的影响[J]. 中华内科杂志, 1998,37(3):200. DOI:
10.3760/j.issn:0578-1426.1998.03.028
.
42
Evans DJ , Taylor DA , Zetterstrom O ,et al. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma[J]. N Engl J Med, 1997,337(20):1412-1418. DOI:
10.1056/NEJM199711133372002
.
43
Ukena D , Harnest U , Sakalauskas R ,et al. Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma[J]. Eur Respir J, 1997,10(12):2754-2760. DOI:
10.1183/09031936.97.10122754
.
44
方萍,孙秀珍,李雅莉,等. 新型Th2细胞因子抑制剂甲磺司特治疗支气管哮喘的临床研究[J]. 西安交通大学学报(医学版), 2009,30(5):575-578.
45
Hui Y , Li L , Qian J ,et al. Efficacy analysis of three-year subcutaneous SQ-standardized specific immunotherapy in house dust mite-allergic children with asthma[J]. Exp Ther Med, 2014,7(3):630-634. DOI:
10.3892/etm.2014.1469
.
46
Wang H , Lin X , Hao C ,et al. A double-blind, placebo-controlled study of house dust mite immunotherapy in Chinese asthmatic patients[J]. Allergy, 2006,61(2):191-197. DOI:
10.1111/j.1398-9995.2005.00913.x
47
Tao L , Shi B , Shi G ,et al. Efficacy of sublingual immunotherapy for allergic asthma: retrospective meta-analysis of randomized, double-blind and placebo-controlled trials[J]. Clin Respir J, 2014,8(2):192-205. DOI:
10.1111/crj.12058
.
48
Papi A , Canonica GW , Maestrelli P ,et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma[J]. N Engl J Med 2007,356(20):2040-2052. DOI:
10.1056/NEJMoa063861
.
49
Calhoun WJ , Ameredes BT , King TS ,et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial[J]. JAMA, 2012,308(10):987-997. DOI:
10.1001/2012.jama.10893
.
50
O′Byrne PM , FitzGerald JM , Bateman ED ,et al. Inhaled combined budesonide-formoterol as needed in mild asthma[J]. N Engl J Med, 2018,378(20):1865-1876. DOI:
10.1056/NEJMoa1715274
.
51
Bateman ED , Reddel HK , O′Byrne PM ,et al. As-needed budesonide-formoterol versus maintenance budesonide in mild asthma[J]. N Engl J Med, 2018,37(20):1877-1887. DOI:
10.1056/NEJMoa1715275
.
52
Wilson AM , Dempsey OJ , Sims EJ ,et al. A comparison of topical budesonide and oral montelukast in seasonal allergic rhinitis and asthma[J]. Clin Exp Allergy, 2001,31(4):616-624. DOI:
10.1046/j.1365-2222.2001.01088.x
53
Yang D , Luo H , Wang J ,et al. Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta-analysis[J]. Clin Respir J, 2013,7(1):74-90. DOI:
10.1111/j.1752-699X.2012.00287.x
.
54
Ducharme FM , Ni Chroinin M , Greenstone I ,et al. Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children[J]. Cochrane Database Syst Rev, 2010, (5):CD005535. DOI:
10.1002/14651858.CD005535.pub2
.
55
Zhong N , Lin J , Mehta P ,et al. Real-life effectiveness of budesonide/formoterol maintenance and reliever therapy in asthma patients across Asia: SMARTASIA study.[J ]. BMC Pulm Med, 2013,13:22. DOI:
10.1186/1471-2466-13-22
.
56
Szefler SJ , Martin RJ , King TS ,et al. Significant variability in response to inhaled corticosteroids for persistent asthma[J]. J Allergy Clin Immunol, 2002,109(3):410-418. DOI:
10.1067/mai.2002.122635
.
57
Ducharme FM , Lasserson TJ , Cates CJ . Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma[J]. Cochrane Database Syst Rev, 2011, (5):CD003137. DOI:
10.1002/14651858.CD003137.pub4
.
58
Wang Y , Wang CZ , Lin KX ,et al. Comparison of inhaled corticosteroid combined with theophylline and double-dose inhaled corticosteroid in moderate to severe asthma[J]. Respirology, 2005,10(2):189-195. DOI:
10.1111/j.1440-1843.2005.00697.x
.
59
Szefler SJ , Murphy K , 3rd Harper T ,et al. A phase Ⅲ randomized controlled trial of tiotropium add-on therapy in children with severe symptomatic asthma[J]. J Allergy Clin Immunol, 2017,140(5):1277-1287. DOI:
10.1016/j.jaci.2017.01.014
.
60
Hamelmann E , Vogelberg C , Szefler SJ ,et al. Tiotropium for the treatment of asthma in adolescents[J]. Expert Opin Pharmacother, 2017,18(3):305-312. DOI:
10.108014656566.2017.1285906
.
61
Nie H , Zhang G , Liu M ,et al. Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma[J]. Respir Med, 2013,107(3):347-354. DOI:
10.1016/j.rmed.2012.12.004
.
62
Powell H , Gibson PG . Inhaled corticosteroid doses in asthma: an evidence-based approach[J]. Med J Aust, 2003,178(5):223-225.
63
Pauwels RA , Löfdahl CG , Postma DS ,et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group[J]. N Engl J Med, 1997,337(20):1405-1411. DOI:
10.1056/NEJM199711133372001
.
64
Peters SP , Kunselman SJ , Icitovic N ,et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma[J]. N Engl J Med, 2010,363(18):1715-1726. DOI:
10.1056/NEJMoa1008770
.
65
Rodrigo GJ , Neffen H , Castro-Rodriguez JA . Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review[J]. Chest, 2011,139(1):28-35. DOI:
10.1378/chest.10-1194
.
66
Petsky HL , Li A , Chang AB . Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults. [J ]. Cochrane Database Syst Rev, 2017,8:CD005603. DOI:
10.1002/14651858.CD005603.pub3
.
67
Powell H , Murphy VE , Taylor DR ,et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial[J]. Lancet, 2011,378(9795):983-990. DOI:
10.1016/S0140-6736(11)60971-9
.
68
张清玲,张筱娴,谢佳星,等. 支气管热成形术治疗重度支气管哮喘的初步临床观察[J]. 中华结核和呼吸杂志, 2016,39(3):183-188. DOI:
10.3760/cma.j.issn.1001-0939.2016.03.008
.
69
农英,苏楠,林江涛,等. 支气管热成形术治疗重度支气管哮喘的有效性和安全性研究[J]. 中华结核和呼吸杂志, 2016,39(3):177-182. DOI:
10.3760/cma.j.issn.1001-0939.2016.03.007
.
70
Gibson PG , Yang IA , Upham JW ,et al. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial[J]. Lancet, 2017,390(10095):659-668. DOI:
10.1016/S0140-6736(17)31281-3
.
71
Brusselle GG , Vanderstichele C , Jordens P ,et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial[J]. Thorax, 2013,68(4):322-329. DOI:
10.1136/thoraxjnl-2012-202698
.
72
Basheti IA , Reddel HK , Armour CL ,et al. Improved asthma outcomes with a simple inhaler technique intervention by community pharmacists[J]. J Allergy Clin Immunol, 2007,119(6):1537-1538. DOI:
10.1016/j.jaci.2007.02.037
.
73
Leuppi JD , Salome CM , Jenkins CR ,et al. Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids[J]. Am J Respir Crit Care Med, 2001,163(2):406-412. DOI:
10.1164/ajrccm.163.2.9912091
.
74
Usmani OS , Kemppinen A , Gardener E ,et al. A randomized pragmatic trial of changing to and stepping down fluticasone/formoterol in asthma[J]. J Allergy Clin Immunol Pract, 2017,5(5):1378-1387.e5. DOI:
10.1016/j.jaip.2017.02.006
.
75
Reddel H , Ware S , Marks G ,et al. Differences between asthma exacerbations and poor asthma control[J]. Lancet, 1999,353(9150):364-369. DOI:
10.1016/S0140-6736(98)06128-5
.
76
Bai TR , Vonk JM , Postma DS ,et al. Severe exacerbations predict excess lung function decline in asthma[J]. Eur Respir J, 2007,30(3):452-456. DOI:
10.1183/09031936.00165106
.
77
Chan-Yeung M , Chang JH , Manfreda J ,et al. Changes in peak flow, symptom score, and the use of medications during acute exacerbations of asthma[J]. Am J Respir Crit Care Med, 1996,154(4Pt 1):889-893. DOI:
10.1164/ajrccm.154.4.8887581
.
78
Cates CJ , Welsh EJ , Rowe BH . Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma[J]. Cochrane Database Syst Rev, 2013(9):CD000052. DOI:
10.1002/14651858.CD000052.pub3
.
79
Holguin F , Cardet JC , Chung KF ,et al. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline[J]. Eur Respir J, 2020,55(1). DOI:
10.1183/13993003.00588-2019
.
80
中华医学会呼吸病学分会哮喘学组,中国哮喘联盟. 重症哮喘诊断与处理中国专家共识[J]. 中华结核和呼吸杂志, 2017,40(11):813-829. DOI:
10.3760/cma.j.issn.1001-0939.2017.11.006
.
81
Diagnosis and Management of Difficult-to-Treat and Severe Asthma in adolescent and adult patients.( https//ginasthma.org)uploads/2019/04/GINA-Severe-asthma-Pocket-Guide-v2.0-wms-1.
82
Lai T , Wang S , Xu Z ,et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis[J]. Sci Rep, 2015,5:8191. DOI:
10.1038/srep08191
.
83
Busse WW , Morgan WJ , Gergen PJ ,et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children[J]. N Engl J Med, 2011,364(11):1005-1015. DOI:
10.1056/NEJMoa1009705
.
84
Li J , Kang J , Wang C ,et al. Omalizumab improves quality of life and asthma control in Chinese patients with moderate to severe asthma: a randomized phase Ⅲ study[J]. Allergy Asthma Immunol Res, 2016,8(4):319-328. DOI:
10.4168/aair.2016.8.4.319
.
85
Khatri S , Moore W , Gibson PG ,et al. Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma[J]. J Allergy Clin Immunol, 2019,143(5):1742-1751. e7. DOI:
10.1016/j.jaci.2018.09.033
.
86
Chung KF . 2-year safety and efficacy results for benralizumab[J]. Lancet Respir Med, 2019,7(1):5-6. DOI:
10.1016/S2213-2600(18)30468-5
.
87
Castro M , Corren J , Pavord ID ,et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma[J]. N Engl J Med, 2018, 28,378(26):2486-2496. DOI:
10.1056/NEJMoa1804092
.
88
中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015)[J]. 中华结核和呼吸杂志, 2016,39(5):323-354. DOI:
10.3760/cma.j.issn.1001-0939.2016.05.003
.
89
Lai K , Chen R , Lin J ,et al. A prospective, multicenter survey on causes of chronic cough in China[J]. Chest, 2013,143(3):613-620. DOI:
10.1378/chest.12-0441
.
90
赖克方,陈如冲,刘春丽,等. 不明原因慢性咳嗽的病因分布及诊断程序的建立[J]. 中华结核和呼吸杂志, 2006,29(2):96-99. DOI:
10.3760/j:issn:1001-0939.2006.02.007
.
91
刘国梁,林江涛.“ 不明原因”慢性咳嗽的病因构成和临床特征分析[J]. 中华结核和呼吸杂志, 2009,32(6):422-425. DOI:
10.3760/cma.j.issn.1001-0939.2009.06.007
.
92
Irwin RS , Corrao WM , Pratter MR . Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy[J]. Am Rev Respir Dis, 1981,123(4Pt 1):413-417. DOI:
10.1164/arrd.1981.123.4.413
.
93
席寅,赖克方,陈如冲,等. 咳嗽变异性哮喘的临床特征及其与典型哮喘的关系[J]. 中华哮喘杂志(电子版), 2011,5(3):150-155. DOI:
10.3969/j.issn.1674-3911.2011.03.001
.
94
赖克方,陈如冲,林玲,等. 不同病因慢性咳嗽临床特征的诊断价值[J]. 中华结核和呼吸杂志, 2009,32(6):418-421. DOI:
10.3760/cma.j.issn.1001-0939.2009.06.006
.
95
Irwin RS , Baumann MH , Bolser DC ,et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines[J]. Chest, 2006,129(1Suppl):1S-23S. DOI:
10.1378/chest.129.1_suppl.1S
.
96
Yuan H , Liu X , Li L ,et al. Clinical and pulmonary function changes in cough variant asthma with small airway disease[J]. Allergy Asthma Clin Immunol, 2019,15:41. DOI:
10.1186/s13223-019-0354-1
.
97
Kim CK , Kim JT , Kang H ,et al. Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma[J]. Clin Exp Allergy, 2003,33(10):1409-1414. DOI:
10.1046/j.1365-2222.2003.01788.x
.
98
Song WJ , Kim HJ , Shim JS ,et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis[J]. J Allergy Clin Immunol, 2017,140(3):701-709. DOI:
10.1016/j.jaci.2016.11.037
.
99
Yi F , Chen R , Luo W ,et al. Validity of fractional exhaled nitric oxide in diagnosis of corticosteroid-responsive cough[J]. Chest, 2016,149(4):1042-1051. DOI:
10.1016/j.chest.2016.01.006
.
100
Cao C , Li W , Hua W ,et al. Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma[J]. J Transl Med, 2017,15(1):171. DOI:
10.1186/s12967-017-1264-y
.
101
Liccardi G , Salzillo A , Sofia M ,et al. Bronchial asthma[J]. Curr Opin Anaesthesiol, 2012,25(1):30-37. DOI:
10.1097/ACO.0b013e32834e7b2e
.
102
Warner DO , Warner MA , Barnes RD ,et al. Perioperative respiratory complications in patients with asthma[J]. Anesthesiology, 1996,85(3):460-467. DOI:
10.1097/00000542-199609000-00003
.
103
Hepner DL , Castells MC . Anaphylaxis during the perioperative period[J]. Anesth Analg, 2003,97(5):1381-1395. DOI:
10.1213/01.ane.0000082993.84883.7d
.
104
Sparr HJ , Beaufort TM , Fuchs-Buder T . Newer neuromuscular blocking agents: how do they compare with established agents?[J]. Drugs, 2001,61(7):919-942. DOI:
10.2165/00003495-200161070-00003
.
105
Rooke GA , Choi JH , Bishop MJ . The effect of isoflurane, halothane, sevoflurane, and thiopental/nitrous oxide on respiratory system resistance after tracheal intubation[J]. Anesthesiology, 1997,86(6):1294-1299. DOI:
10.1097/00000542-199706000-00010
.
106
Lawrence VA , Cornell JE , Smetana GW ,et al. Strategies to reduce postoperative pulmonary complications after noncardiothoracic surgery: systematic review for the American College of Physicians[J]. Ann Intern Med, 2006,144(8):596-608. DOI:
10.7326/0003-4819-144-8-200604180-00011
.
107
Qaseem A , Snow V , Fitterman N ,et al. Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery: a guideline from the American College of Physicians[J]. Ann Intern Med, 2006,144(8):575-580. DOI:
10.7326/0003-4819-144-8-200604180-00008
.
108
Nowak R , Corbridge T , Brenner B . Noninvasive ventilation[J]. J Allergy Clin Immunol, 2009,124(2Suppl):S15-S18. DOI:
10.1016/j.jaci.2009.05.009
.
109
杨树升,林丽. 36例阿司匹林哮喘回顾性分析[J]. 中国呼吸与危重监护杂志, 2012,11(5):448-451. DOI:
10.3969/j.issn.1671-6205.2012.05.007
.
110
辛晓峰,施毅. 阿司匹林性哮喘的呼吸道炎症在其发病机制中的作用[J]. 医学研究生学报, 2005,18(2):174-177. DOI:
10.3969/j.issn.1008-8199.2005.02.023
.
111
Chu S , Huang L , Bao Y ,et al. In Utero Exposure to Aspirin and Risk of Asthma in Childhood[J]. Epidemiology, 2016,27(5):726-731. DOI:
10.1097/EDE.0000000000000519
.
112
Barranco P , Bobolea I , Larco JI ,et al. Diagnosis of aspirin-induced asthma combining the bronchial and the oral challenge tests: a pilot study[J]. J Investig Allergol Clin Immunol, 2009,19(6):446-452.
113
Świerczyńska-Krępa M , Sanak M , Bochenek G ,et al. Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: a double-blind study[J]. J Allergy Clin Immunol, 2014,134(4):883-890. DOI:
10.1016/j.jaci.2014.02.041
.
114
Heart National ,Lung, aB Institute ,National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update[J]. J Allergy Clin Immunol, 2005,115(1):34-46. DOI:
10.1016/j.jaci.2004.10.023
.
115
Källén B , Rydhstroem H , Aberg A . Asthma during pregnancy--a population based study[J]. Eur J Epidemiol, 2000,16(2):167-171. DOI:
10.1023/a:1007678404911
.
116
Ali Z , Nilas L , Ulrik CS . Excessive gestational weight gain in first trimester is a risk factor for exacerbation of asthma during pregnancy: A prospective study of 1283 pregnancies[J]. J Allergy Clin Immunol, 2018,141(2):761-767. DOI:
10.1016/j.jaci.2017.03.040
.
117
Murphy VE , Schatz M . Asthma in pregnancy: a hit for two[J]. Eur Respir Rev, 2014,23(131):64-68. DOI:
10.1183/09059180.00008313
.
118
Getahun D , Ananth CV , Peltier MR ,et al. Acute and chronic respiratory diseases in pregnancy: associations with placental abruption[J]. Am J Obstet Gynecol, 2006,195(4):1180-1184. DOI:
10.1016/j.ajog.2006.07.027
.
119
Cohen JM , Bateman BT , Huybrechts KF ,et al. Poorly controlled asthma during pregnancy remains common in the United States[J]. J Allergy Clin Immunol Pract, 2019,7(8):2672-2680.e10. DOI:
10.1016/j.jaip.2019.05.043
.
120
Gluck JC , Gluck PA . Asthma controller therapy during pregnancy[J]. Am J Obstet Gynecol, 2005,192(2):369-380. DOI:
10.1016/j.ajog.2004.07.056
.
121
Mihălţan FD , Antoniu SA , Ulmeanu R . Asthma and pregnancy: therapeutic challenges[J]. Arch Gynecol Obstet, 2014,290(4):621-627. DOI:
10.1007/s00404-014-3342-1
.
122
Wolsk HM , Harshfield BJ , Laranjo N ,et al. Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: secondary analyses from the Vitamin D antenatal asthma reduction Trial[J]. J Allergy Clin Immunol, 2017,140(5):1423-1429.e5. DOI:
10.1016/j.jaci.2017.01.013
.
123
McCallister JW . Asthma in pregnancy: management strategies[J]. Curr Opin Pulm Med, 2013,19(1):13-17. DOI:
10.1097/MCP.0b013e32835a5bf3
.
124
Morten M , Collison A , Murphy VE ,et al. Managing asthma in pregnancy (MAP) trial: FENO levels and childhood asthma[J]. J Allergy Clin Immunol, 2018,142(6):1765-1772.e4. DOI:
10.1016/j.jaci.2018.02.039
.
125
Vrieze A , Postma DS , Kerstjens HA . Perimenstrual asthma: a syndrome without known cause or cure[J]. J Allergy Clin Immunol, 2003,112(2):271-282. DOI:
10.1067/mai.2003.1676
.
126
Rao CK , Moore CG , Bleecker E ,et al. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the severe asthma research program[J]. Chest, 2013,143(4):984-992. DOI:
10.1378/chest.12-0973
.
127
Skoczyński S , Semik-Orzech A , Szanecki W ,et al. Perimenstrual asthma as a gynecological and pulmonological clinical problem[J]. Adv Clin Exp Med, 2014,23(4):665-668. DOI:
10.17219/acem/37250
.
128
Pasaoglu G , Mungan D , Abadoglu O ,et al. Leukotriene receptor antagonists: a good choice in the treatment of premenstrual asthma?[J]. J Asthma, 2008,45(2):95-99. DOI:
10.1080/02770900701751799
.
129
Gibson PG , McDonald VM . Asthma-COPD overlap 2015: now we are six[J]. Thorax, 2015,70(7):683-691. DOI:
10.1136/thoraxjnl-2014-206740
.
130
Tho NV , Park HY , Nakano Y . Asthma-COPD overlap syndrome (ACOS): A diagnostic challenge[J]. Respirology, 2016,21(3):410-418. DOI:
10.1111/resp.12653
.
131
Gibson PG , Powell H , Coughlan J ,et al. Self-management education and regular practitioner review for adults with asthma[J]. Cochrane Database Syst Rev, 2003,(1):CD001117. DOI:
10.1002/14651858.CD001117
.
132
林江涛,何权瀛,姚婉贞,等. 北京市城区支气管哮喘患者的控制现状及对疾病认知程度的调查[J]. 中华结核和呼吸杂志, 2007,30(7):494-497. DOI:
10.3760/j.issn:1001-0939.2007.07.006
.
133
王雯,黄克武,刘秋云,等. 支气管哮喘规范化管理与教育对哮喘控制的效果评析[J]. 中华哮喘杂志(电子版), 2011,5(6):415-419. DOI:
10.3969/j.issn.1674-3911.2011.06.007
.
134
Williams LK , Pladevall M , Xi H ,et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma[J]. J Allergy Clin Immunol, 2004,114(6):1288-1293. DOI:
10.1016/j.jaci.2004.09.028
.
135
Gamble J , Stevenson M , McClean E ,et al. The prevalence of nonadherence in difficult asthma[J]. Am J Respir Crit Care Med, 2009,180(9):817-822. DOI:
10.1164/rccm.200902-0166OC
.
136
母双,何权瀛,林江涛.“ 三位一体”支气管哮喘教育管理模式对支气管哮喘患者病情控制水平的影响[J]. 中华内科杂志, 2008,47(8):630-633. DOI:
10.3321/j.issn:0578-1426.2008.08.006
.
137
Fink JB , Rubin BK . Problems with inhaler use: a call for improved clinician and patient education[J]. Respir Care, 2005,50(10):1360-1374.
138
中华医学会呼吸病学分会哮喘学组. 支气管哮喘患者自我管理中国专家共识[J]. 中华结核和呼吸杂志, 2018,41(3):171-178. DOI:
10.3760/cma.j.issn.1001-0939.2018.03.005
.
139
刘晓静,杜春玲,陈智鸿,等. 物联网医学在哮喘管理中应用的研究进展[J]. 复旦学报(医学版), 2019,46(1):98-102. DOI:
10.3969/j.issn.1672-8467.2019.01.017
.
140
Best KP , Gold M , Kennedy D ,et al. Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials[J]. Am J Clin Nutr, 2016,103(1):128-143. DOI:
10.3945/ajcn.115.111104
.
141
Best KP , Sullivan T , Palmer D ,et al. Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial[J]. Pediatrics, 2016,137(6):e20154443. DOI:
10.1542/peds.2015-4443
.
142
Hansen S , Strøm M , Maslova E ,et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring[J]. J Allergy Clin Immunol, 2017,139(1):104-111.e4. DOI:
10.1016/j.jaci.2016.02.042
.
143
Best KP , Sullivan TR , Palmer DJ ,et al. Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood-a longitudinal analysis of long-term follow-up of a randomized controlled trial[J]. World Allergy Organ J, 2018,11(1):10. DOI:
10.1186/s40413-018-0190-7
.
144
Stratakis N , Roumeliotaki T , Oken E ,et al. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts[J]. Int J Epidemiol, 2017,46(5):1465-1477. DOI:
10.1093/ije/dyx007
.
145
Forno E , Young OM , Kumar R ,et al. Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma[J]. Pediatrics, 2014,134(2):e535-546. DOI:
10.1542/peds.2014-0439
.
146
Bener A , Ehlayel MS , Alsowaidi S ,et al. Role of breast feeding in primary prevention of asthma and allergic diseases in a traditional society[J]. Eur Ann Allergy Clin Immunol, 2007,39(10):337-343.
147
Ehlayel MS , Bener A . Duration of breast-feeding and the risk of childhood allergic diseases in a developing country[J]. Allergy Asthma Proc, 2008,29(4):386-391. DOI:
10.2500/aap.2008.29.3138
.
148
Brozek JL , Bousquet J , Baena-Cagnani CE ,et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision[J]. J Allergy Clin Immunol, 2010,126(3):466-476. DOI:
10.1016/j.jaci.2010.06.047
.
149
Nurmatov U , Devereux G , Sheikh A . Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis[J]. J Allergy Clin Immunol, 2011,127(3):724-733.e1-30. DOI:
10.1016/j.jaci.2010.11.001
.
150
Azad MB , Coneys JG , Kozyrskyj AL ,et al. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis[J]. BMJ, 2013,347:f6471. DOI:
10.1136/bmj.f6471
.
151
Zuccotti G , Meneghin F , Aceti A ,et al. Probiotics for prevention of atopic diseases in infants systematic review and meta-analysis.Allergy[J]. Allergy, 2015,70(11):1356-1371. DOI:
10.1111all.12700
.
152
Incorvaia C , Riario-Sforza GG . Allergy testing in the diagnosis of asthma[J]. Lancet Respir Med, 2015,3(5):e16. DOI:
10.1016/S2213-2600(15)00089-2
.
153
Li J , Sun B , Huang Y ,et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009,64(7):1083-1092. DOI:
10.1111/j.1398-9995.2009.01967.x
.
154
Li J , Wang H , Chen Y ,et al. House dust mite sensitization is the main risk factor for the increase in prevalence of wheeze in 13‐to 14‐year‐old schoolchildren in Guangzhou city, China[J]. Clin Exp Allergy, 2013,43(10):1171-1179. DOI:
10.1111/cea.12157
.
155
Melén E , Wickman M , Nordvall SL ,et al. Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children[J]. Allergy, 2001,56(7):646-652. DOI:
10.1034/j.1398-9995.2001.00387.x
.
156
Takkouche B , González-Barcala FJ , Etminan M ,et al. Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis[J]. Allergy, 2008,63(7):857-864. DOI:
10.1111/j.1398-9995.2008.01732.x
.
157
Ownby DR , Johnson CC , Peterson EL . Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age[J]. JAMA, 2002,288(8):963-972. DOI:
10.1001/jama.288.8.963
.
158
Etminan M , Sadatsafavi M , Jafari S ,et al. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis[J]. Chest, 2009,136(5):1316-1323. DOI:
10.1378/chest.09-0865
.
159
Eyers S , Weatherall M , Jefferies S ,et al. Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis[J]. Clin Exp Allergy, 2011,41(4):482-489. DOI:
10.1111/j.1365-2222.2010.03691.x
.
160
Burke H , Leonardi-Bee J , Hashim A ,et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze:systematic review and meta-analysis[J]. Pediatrics, 2012,129(4):735-744. DOI:
10.1542/peds.2011-2196
.
161
Bowatte G , Lodge C , Lowe AJ ,et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies[J]. Allergy, 2015,70(3):245-256. DOI:
10.1111/all.12561
.
162
中华医学会变态反应分会呼吸过敏学组. 中国过敏性哮喘诊治指南(第一版,2019年)[J]. 中华内科杂志, 2019,58(9):636-655. DOI:
10.3760/cma.j.issn.0578-1426.2019.09.004
.
163
Morales E , Garcia-Esteban R , de la Cruz OA ,et al. Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age[J]. Thorax, 2015,70(1):64-73. DOI:
10.1136/thoraxjnl-2014-205413
.
164
É Lavigne , Bélair MA , Rodriguez Duque D ,et al. Effect modification of perinatal exposure to air pollution and childhood asthma incidence[J]. Eur Respir J, 2018,51(3):1701884. DOI:
10.1183/13993003.01884-2017
.
165
Gaffin JM , Hauptman M , Petty CR ,et al. Nitrogen dioxide exposure in school classrooms of inner-city children with asthma[J]. J Allergy Clin Immunol, 2018,141(6):2249-2255.e2. DOI:
10.1016/j.jaci.2017.08.028
.
166
Burbank AJ , Peden DB . Assessing the impact of air pollution on childhood asthma morbidity: how, when, and what to do[J]. Curr Opin Allergy Clin Immunol, 2018,18(2):124-131. DOI:
10.1097/ACI.0000000000000422
.
167
Slaughter JC , Lumley T , Sheppard L ,et al. Effects of ambient air pollution on symptom severity and medication use in children with asthma[J]. Ann Allergy Asthma Immunol, 2003,91(4):346-353. DOI:
10.1016/S1081-1206(10)61681-X
.
168
Dunea D , Iordache S , Liu HY ,et al. Quantifying the impact of PM2.5 and associated heavy metals on respiratory health of children near metallurgical facilities[J]. Environ Sci Pollut Res Int, 2016,23(15):15395-15406. DOI:
10.1007/s11356-016-6734-x
.
169
Haahtela T , Holgate S , Pawankar R ,et al. The biodiversity hypothesis and allergic disease: world allergy organization position statement[J]. World Allergy Organ J, 2013,6(1):3. DOI:
10.1186/1939-4551-6-3
.
170
Feng M , Yang Z , Pan L ,et al. Associations of early life exposures and environmental factors with asthma among children in rural and urban areas of Guangdong, China[J]. Chest, 2016,4(149):1030-1041. DOI:
10.1016/j.chest.2015.12.028
.
171
Genuneit J . Exposure to farming environments in childhood and asthma and wheeze in rural populations: a systematic review with meta-analysis[J]. Pediatr Allergy Immunol, 2012,23(6):509-518. DOI:
10.1111/j.1399-3038.2012.01312.x
.
172
Thavagnanam S , Fleming J , Bromley A ,et al. A meta-analysis of the association between Caesarean section and childhood asthma[J]. Clin Exp Allergy, 2008,38(4):629-633. DOI:
10.1111/j.1365-2222.2007.02780.x
.
173
Flanigan C , Sheikh A , DunnGalvin A ,et al. Prenatal maternal psychosocial stress and offspring′s asthma and allergic disease: a systematic review and meta-analysis[J]. Clin Exp Allergy, 2018,48(4):403-414. DOI:
10.1111/cea.13091
.
174
Kozyrskyj AL , Mai XM , McGrath P ,et al. Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma[J]. Am J Respir Crit Care Med, 2008,177(2):142-147. DOI:
10.1164/rccm.200703-381OC
.
175
Guyatt GH , Oxman AD , Kunz R ,et al. Going from evidence to recommendations[J]. BMJ, 2008,336(7652):1049-1051. DOI:
10.1136/bmj.39493.646875.AE
.
备注信息
A
周新，上海交通大学附属第一人民医院呼吸与危重症医学科 200080，Email:
mocdef.3ab6135uohzx
B
沈华浩，浙江大学医学院附属第二医院呼吸与危重症医学科 310009，Email:
mocdef.3ab61nehsoahauh
C
钟南山，广州医科大学附属第一医院呼吸与危重症医学科广州呼吸健康研究院国家呼吸系统疾病临床医学研究中心510120，Email:
mocdef.3ab61.piv nahsnan
D
中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南（2020年版）[J]. 中华结核和呼吸杂志, 2020, 43(12): 1023-1048. DOI: 10.3760/cma.j.cn112147-20200618-00721.
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